BDBM50598792 CHEMBL5188380

SMILES c1ccc(cc1)[C@H]2[C@H](CCCN2Cc3ccc(cc3N)C(=O)O)O[C@H](CO)c4cc(cc(c4)Cl)Cl

InChI Key InChIKey=WIHIMICVVOCQNM-UHFFFAOYSA-N

Data  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50598792   

TargetcGMP-dependent protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50598792(CHEMBL5188380)
Affinity DataEC50:  1.68E+5nMAssay Description:Activation of basal state recombinant PKG1alpha (unknown origin) using Glass-tide peptide substrate incubated for 30 mins followed by ATP addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50598792(CHEMBL5188380)
Affinity DataEC50:  290nMAssay Description:Activation of cGMP induced partially activated state recombinant PKG1alpha (unknown origin) using Glass-tide peptide substrate incubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50598792(CHEMBL5188380)
Affinity DataEC50:  3.33E+4nMAssay Description:Activation of PKG1alpha in human HEK293 cells stably expressing VASP assessed as VSAP phosphorylation at Ser 239 incubated for 45 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent protein kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50598792(CHEMBL5188380)
Affinity DataEC50:  3.20E+3nMAssay Description:Activation of cGMP induced partially activated state recombinant human full length N-terminal His tagged PKG1beta expressed in Baculovirus infected S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)