BDBM50615045 CHEMBL5274503

SMILES CC(C)(c1cccc(n1)N2c3c(cnc(n3)Nc4ccc(cc4)N5CCN(CC5)C)C(=O)N2c6ccccc6OC)O

InChI Key InChIKey=YRSUINBEIRGTSA-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50615045   

TargetSerine/threonine-protein kinase PLK1(Human)
Emd Serono

Curated by ChEMBL
LigandPNGBDBM50615045(CHEMBL5274503)
Affinity DataIC50: 4.35E+3nMAssay Description:Inhibition of human N-terminal His6-tagged recombinant full-length PLK1 expressed in baculovirus infected Sf9 cells incubated for 15 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetWee1-like protein kinase(Human)
Emd Serono

Curated by ChEMBL
LigandPNGBDBM50615045(CHEMBL5274503)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetWee1-like protein kinase(Human)
Emd Serono

Curated by ChEMBL
LigandPNGBDBM50615045(CHEMBL5274503)
Affinity DataIC50: 542nMAssay Description:Inhibition of WEE1 in human U2OS cells incubated for 1 hr by mesoscale discovery assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)