BDBM661078 (S)-N-hydroxy-3-(4-methoxyphenyl)-2-(4-((5-(pyridin-2-yl)thiophene-2-sulfonamido)methyl)-1H-1,2,3-triazol-1-yl)propanamide::US20240101542, Compound 25

SMILES COc1ccc(C[C@@H](C(=O)NO)n2cc(CNS(=O)(=O)c3ccc(s3)-c3ccccn3)nn2)cc1

InChI Key InChIKey=VCCACZUFRCVVFN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 661078   

TargetEndoplasmic reticulum aminopeptidase 1 (ERAP1)(Human)
Universite De Lille

US Patent
LigandPNGBDBM661078(US20240101542, Compound 25 | (S)-N-hydroxy-3-(4-me...)
Affinity DataIC50: 500nMAssay Description:The enzymatic activity of ERAP1 or 2 was assayed using L-AMC (L-Leucine-7-amido-4-methylcoumarin hydrochloride) or R-AMC (L-Arginine-7-amido-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
Go to US Patent

TargetEndoplasmic reticulum aminopeptidase 2(Human)
Universite De Lille

US Patent
LigandPNGBDBM661078(US20240101542, Compound 25 | (S)-N-hydroxy-3-(4-me...)
Affinity DataIC50: 5.00E+3nMAssay Description:The enzymatic activity of ERAP1 or 2 was assayed using L-AMC (L-Leucine-7-amido-4-methylcoumarin hydrochloride) or R-AMC (L-Arginine-7-amido-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
Go to US Patent

TargetEndoplasmic reticulum aminopeptidase 2(Human)
Universite De Lille

US Patent
LigandPNGBDBM661078(US20240101542, Compound 25 | (S)-N-hydroxy-3-(4-me...)
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetInterleukin-1 receptor antagonist protein(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM661078(US20240101542, Compound 25 | (S)-N-hydroxy-3-(4-me...)
Affinity DataIC50: 186nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEndoplasmic reticulum aminopeptidase 1 (ERAP1)(Human)
Universite De Lille

US Patent
LigandPNGBDBM661078(US20240101542, Compound 25 | (S)-N-hydroxy-3-(4-me...)
Affinity DataIC50: 5.50E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed