BDBM86124 LDHA Inhibitor, 20

SMILES c1cc(ccc1OC(C(=O)O)C(=O)O)Br

InChI Key InChIKey=GZMFZHIPGZSUHI-UHFFFAOYSA-N

Data  1 IC50  2 Kd

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 86124   

TargetL-lactate dehydrogenase A chain(Rat)
Astrazeneca

LigandPNGBDBM86124(LDHA Inhibitor, 20)
Affinity DataKd:  2.10E+5nMpH: 7.4Assay Description:A BIAcore 3000 or a BIAcore S51 instrument (GE Healthcare) was used to detect binding interactions using a direct binding assay format.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetL-lactate dehydrogenase A chain(Rat)
Astrazeneca

LigandPNGBDBM86124(LDHA Inhibitor, 20)
Affinity DataKd:  4.70E+5nMpH: 7.5Assay Description:NMR spectra were acquired on Bruker Avance 600 MHz spectrometers at 298 K using a 5 mm triple-resonance HCN cryoprobe. Ligand binding was detected u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetL-lactate dehydrogenase A chain(Rat)
Astrazeneca

LigandPNGBDBM86124(LDHA Inhibitor, 20)
Affinity DataIC50: 5.00E+5nMpH: 7.5 T: 2°CAssay Description:Enzyme assay using lactate dehydrogenase A (LDHA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)