BDBM92338 Wyq16#

SMILES CCCc1c2c(n(n1)C)C(=O)NC(=N2)c3cc(ccc3OCC)S(=O)(=O)NC(=O)OC(C)C

InChI Key InChIKey=RGTRFWTZGHUUBF-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 92338   

TargetPhosphodiesterase(Trypanosoma cruzi)
University of North Carolina

LigandPNGBDBM92338(Wyq16#)
Affinity DataIC50: 230nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
University of North Carolina

LigandPNGBDBM92338(Wyq16#)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2012
Entry Details Article
PubMed
TargetPhosphodiesterase(Trypanosoma cruzi)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM92338(Wyq16#)
Affinity DataIC50: 230nMAssay Description:Inhibition of N-terminal His6-tagged Trypanosoma cruzi 427 PDEC catalytic domain (270 to 614 residues) expressed in Escherichia coli BL21-CodonPlus c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphodiesterase(Trypanosoma cruzi)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM92338(Wyq16#)
Affinity DataIC50: 230nMAssay Description:Inhibition of N-terminal His6-tagged Trypanosoma cruzi 427 PDEC catalytic domain (270 to 614 residues) expressed in Escherichia coli BL21-CodonPlus c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)