Release Notes for 2025-07-28: Number of new affinity data: 5782 Number of compounds (ligands) new to BindingDB: 3666 Number of Targets new to BindingDB: 5 New Targets: Bromodomain-containing protein 4 [348-457] (unmapped): 17 inhibitors DNA polymerase theta [1792-2590] (O75417[1792-2509]): 36 inhibitors Interleukin-17A/Interleukin-17 receptor A [N206D,N265D] (unmapped): 28 inhibitors Receptor-type tyrosine-protein kinase FLT3 [F691L] (P36888[F691L]): 6 inhibitors Tyrosine-protein kinase JAK3 Protein [521-781] (unmapped): 13 inhibitors Number of new Entries: 50 PubMed id or Patent id Title US12240811 N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, pharmaceutical composition and uses thereof US12240821 Inhibitors of guanosine monophosphate synthetase as therapeutic agents US12240825 Oxexin 1 receptor antagonists US12240835 Substituted benzamides as intermediates in the synthesis of inhibitors of tyrosine kinase enzymatic activity US12240838 Inhibiting agents for Bruton's tyrosine kinase US12240839 Cyclobutyl dihydroquinoline sulfonamide compounds US12247004 2-amino-N-(amino-oxo-aryl-lambda6-sulfanylidene)acetamide compounds and their therapeutic use US12247013 Indane derivatives for use in the treatment of bacterial infection US12247015 3-amino-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of MRGX2 US12247029 Heterocyclic compounds as class II phosphoinositide 3-kinase inhibitors US12247031 Cyclobutyl pyrazolopyrimidine PDE9 inhibitors US12251379 Methods of inhibiting formation of alpha synuclein aggregates US12252491 IL-17A inhibitors US12252493 Imidazo[1,2-c]pyrimidine derivatives as PRC2 inhibitors for treating cancer US20250064761 SUBSTITUTED BENZAMIDES AND THEIR USE IN THERAPY US20250064789 KETOAMIDE DERIVATIVES AND PHARMACEUTICAL USES THEREOF US20250064791 5-[[4-[2-[5-(1-HYDROXYETHYL)PYRIDIN-2-YL]ETHOXY]PHENYL]METHYL]-1,3-THIAZOLIDINE-2,4-DIONE AND ITS SALTS FOR USE IN THE TREATMENT OF MITOCHONDRIAL DISEASES US20250066290 DHODH INHIBITORS CONTAINING A CARBOXYLIC ACID BIOISOSTERE US20250066318 HETEROCYCLIC COMPOUNDS AS DYRK1A INHIBITORS US20250066337 Amorphous Form of (S)-2-(5-((3-Ethoxypyridin-2-YL)Oxy)Pyridin-3-YL)-N-(Tetrahydrofuran-3-YL)Pyrimidine-5-Carboxamide US20250066338 CERTAIN 3-AZABICYCLO[3.1.0]HEXANES AS GLP-1 RECEPTOR MODULATORS US20250066345 COMPOSITIONS AND METHODS OF USE TO TREAT 12-LIPOXYGENASE (12-LOX) MEDIATED DISEASES US20250066349 CYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEUROLOGICAL DISORDERS US20250066350 AROMATIC HETEROCYCLE-SUBSTITUTED COMPOUNDS, AND PREPARATION METHOD THEREFOR AND USE THEREOF US20250066353 VANIN-1 INHIBITORS US20250066363 Bicyclic DGK Inhibitors US20250066368 DNA POLYMERASE THETA INHIBITOR AND USE THEREOF US20250066370 BICYCLIC TRIAZINE DERIVATIVES FOR THE TREATMENT OF CANCER US20250066372 HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH US20250066377 AMINO CHROMEN-2-ONE MODULATORS OF POLRMT US20250066383 PDE 7 MODULATOR COMPOUNDS US20250066388 1,3,4,7-TETRAHYDRO-2H-PYRROLO[3',2':5,6]PYRIDO[2,3-B][1,4]OXAZEPINE BCL-2 INHIBITORS US20250073340 SPIROCYCLIC MDM2 MODULATOR AND USES THEREOF US20250073358 AROMATIC VINYL COMPOUND, METAL COMPLEX THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF US20250074891 BIFUNCTIONAL SULPHONAMIDE COMPOUNDS US20250074895 CDK2 INHIBITORS AND METHODS OF MAKING AND USING SAME US20250074907 INHIBITORS OF SARS-COV-2 US20250074910 MENIN INHIBITOR AND USE THEREOF US20250074911 MACROCYCLIC BTK INHIBITORS US20250074919 Heteroaryl compounds as inhibitors of irak4, compositions and applications thereof US20250074920 MACROCYCLIC COMPOUNDS AND USE AS KINASE INHIBITORS US20250082630 METHODS OF TREATING BRAIN TUMOURS AND NEUROBLASTOMAS US20250082761 DUAL-TARGETED RNA POLYMERASE INHIBITORS: CONJUGATES OF BENZOXAZINO- AND SPIRO-RIFAMYCINS WITH N ALPHA-AROYL-N-ARYL-PHENYLALANINAMIDES US20250084039 4-SUBSTITUTED AMINOISOQUINOLINE DERIVATIVES US20250084060 PRMT5 INHIBITORS AND METHODS OF TREATMENT US20250084067 PYRAZOLE-SUBSTITUTED CYCLOPENTANOL ESTER DERIVATIVE AND USE THEREOF US20250084074 SUBSTITUTED HETEROCYCLES AS HSET INHIBITORS US20250084084 Crystalline form of (2R)-2-(5-fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3-pyrrolidin]-1-yl]propan-1-one US20250084095 Aminopyrimidine Derivatives as Cyclin-Dependent Kinase Inhibitors US20250084096 TERT-BUTYL (S)-2-(4-(PHENYL)-6H-THIENO[3, 2-F][1, 2, 4]TRIAZOLO[4, 3-A] [1,4]DIAZEPIN-6-YL) ACETATE DERIVATIVES AND RELATED COMPOUNDS AS BROMODOMAIN BRD4 INHIBITORS FOR TREATING CANCER