Release Notes for 2025-09-01: Number of new affinity data: 10157 Number of compounds (ligands) new to BindingDB: 6581 Number of Targets new to BindingDB: 16 New Targets: Cyclin-Dependent Kinase 2 and Cyclin E1 (P24864): 4 inhibitors Cyclin-Dependent Kinase 9 and Cyclin T1 (O60563): 5 inhibitors Cytosolic non-specific dipeptidase (Q96KP4): 112 inhibitors Glucokinase/Phosphotransferase (A0A2V2UV62,Q8ST54): 60 inhibitors Histone acetyltransferase KAT7/Bromodomain-containing protein 1 (Q92794,O95696): 55 inhibitors Histone acetyltransferase KAT7/Peregrin (Q92794,O95251): 54 inhibitors Histone acetyltransferase KAT7/Protein Jade-1 (Q92794,Q6IE81): 274 inhibitors Mucin-5B (Q9HC84): 190 inhibitors Phosphatidylinositol 4-kinase alpha/GTPase KRas [1-169,G12C,C51S,C80L,C118S] (P01116[G12C,C51S,C80L,C118S],P42356): 125 inhibitors Pyrrole-2-carboxylic acid decarboxylase (Q9I6N5): 14 inhibitors RAC-alpha serine/threonine-protein kinase [E17K]/RAC-beta serine/threonine-protein kinase (P31751,P31749[E17K]): 140 inhibitors RAF Proto-oncogen Serine/Threonine-Protein Kinase/GTPase KRas [1-169,G12C,C51S,C80L,C118S] (P01116[G12C,C51S,C80L,C118S],P04049): 320 inhibitors ripk1 (Q13546): 162 inhibitors t2 (unmapped): 15 inhibitors t4 (unmapped): 14 inhibitors Number of new Entries: 68 PubMed id or Patent id Title US12263156 Use of small molecule inhibitors of the BfrB:Bfd interaction in biofilms US12263163 Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as a Syk inhibitor US12263171 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use US12264155 Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use as ATR kinase inhibitors US12268667 JAK1 pathway inhibitors for the treatment of prurigo nodularis US12268687 Compounds and uses thereof US12268694 Combination pharmaceutical agents as RSV inhibitors US12269804 Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency US12269819 Small molecule inhibitors of Galectin-3 US12281080 Quinoline-based compounds and methods of inhibiting CDK8/19 US12281099 Isoindolinone substituted indoles and derivatives as RAS inhibitors US12281118 Nitrogen-containing fused heterocyclic SHP2 inhibitor compound, preparation method, and use US12281126 Inhibitors of cyclin-dependent kinase 7 and uses thereof US12286422 Methods and compositions of 4-substituted benzoylpiperazine-1-substituted carbonyls as β-catenin/B-cell lymphoma 9 inhibitors US12286428 Tricyclic heteroaryl compounds useful as IRAK4 inhibitors US12286435 Compound having benzo seven-membered ring structure, preparation method therefor, and use thereof US20250108123 COMPOUND-LINKER CONSTRUCTS COMPRISING NOVEL COMPOUNDS USEFUL AS STING AGONISTS AND USES THEREOF US20250108139 PEPTIDE UREA DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING PEPTIDE UREA DERIVATIVE, AND APPLICATION OF PEPTIDE UREA DERIVATIVE US20250109120 INDOLINE DERIVATIVES FOR TREATMENT AND/OR PREVENTION OF TUMOR OR CELL PROLIFERATIVE AND FIBROSIS DISEASES US20250109139 TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF US20250109156 INDOLE-CONTAINING MACROCYCLIC COMPOUNDS AND USES THEREOF US20250114338 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF US20250114359 METHODS FOR INHIBITING PARASITIC GLUCOKINASE AND/OR HEXOKINASE US20250114361 PYRAZOLOPYRIMIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF US20250115561 BIPHENYL-SUBSTITUTED EPITHELIAL SODIUM CHANNEL BLOCKING COMPOUNDS US20250115563 MODULATORS OF THE INTEGRATED STRESS PATHWAY US20250115569 SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS US20250115572 SPIROCYCLIC PIPERIDINYL DERIVATIVES AS COMPLEMENT FACTOR B INHIBITORS AND USES THEREOF US20250115576 THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF US20250115577 BCL-2 Inhibitors US20250115578 AROMATIC FUSED RING NAV1.8 INHIBITOR, AND USE THEREOF US20250115583 BICYCLIC INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS US20250115590 MATRIX METALLOPROTEINASE (MMP) INHIBITORS AND METHODS OF USE THEREOF US20250115591 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS US20250115594 ANTIBACTERIAL AGENTS: SOLUBLE SALTS AND AQUEOUS FORMULATIONS OF PYRONINS US20250115598 BIFUNCTIONAL ARYLSULPHONAMIDE COMPOUNDS US20250115600 COVALENT MODIFIERS OF AKT1 AND USES THEREOF US20250115607 PYRIDINE DERIVATIVES US20250115609 AROMATIC HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR AND USES THEREOF US20250120927 CNDP2 MODULATORS AND METHODS FOR THEIR USE US20250122166 SUBSTITUTED N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-4-YL)METHYL)BENZAMIDE ANALOGS AS MODULATORS OF CEREBLON PROTEIN US20250122174 Heteroaryl Compounds As HPK1 Inhibitors And Methods Of Using Same US20250122182 MYST Inhibitors US20250122183 Nitrogen-Linked Benzisoxazole Sulfonamide Derivatives US20250122202 EGFR INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF US20250122221 SIX-MEMBERED CYCLOTHIAZOLE COMPOUND AND USE THEREOF US20250122223 HETEROCYCLIC COMPOUNDS AS UBIQUITIN SPECIFIC PROTEASE 7 INHIBITORS US20250127780 IMIDAZO[4,5-B]PYRIDINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS SIK MODULATORS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS US20250127788 PHARMACEUTICAL COMPOSITION CONTAINING TRIAZINE DERIVATIVE US20250127800 PYRIMIDINE OR PYRIDINE DERIVATIVE AND MEDICINAL USE THEREOF US20250127903 SUBSTITUTED PIPERIDINE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION US20250127913 BIFUNCTIONAL FOLATE RECEPTOR BINDING COMPOUNDS US20250127937 FAP INHIBITOR US20250129027 FATTY ACID AMIDE HYDROLASE MODULATORS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF US20250129032 PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF US20250129041 MOLECULAR GLUE AND USES THEREOF US20250129048 MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF US20250129049 1H-PYRAZOLE-3-AMINE DERIVATIVE HAVING BICYCLIC BACKBONE US20250129055 GLUCOSIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF US20250129067 PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGFR) ALPHA INHIBITORS AND USES THEREOF US20250129068 4-(2-PYRAZOLO[3,4-B]PYRIDINE-5-YL)ETHYNYL-2-PYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS US20250129069 TRIAZOLO WRN INHIBITORS US20250129073 INHIBITOR OF RECEPTOR-INTERACTING PROTEIN KINASE 1, AND PREPARATION METHOD AND USE THEREFOR US20250129078 ERBB2 INHIBITORS US20250129088 CEREBLON E3 UBIQUITIN LIGASE INHIBITOR US20250129103 METHODS FOR TREATMENT OF CANCER US20250129104 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF WO2025125695 CHEMICAL COMPOUNDSID50000167790940 P. DOC 2025-05-07 FILING NO.:19