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Report error Found 275 Enz. Inhib. hit(s) with Target = '1,3-beta-glucan synthase'
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478216(CHEBI:600520 | Micafungin | Mycamine)
Affinity DataIC50: 0.117nMAssay Description:Inhibition of Candida tropicalis T3 blood stream isolate glucan synthase subunit FKS1p with FLTLS/PLRDP mutant at monophasic kineticsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478216(CHEBI:600520 | Micafungin | Mycamine)
Affinity DataIC50: 0.171nMAssay Description:Inhibition of Candida tropicalis T19 blood stream isolate glucan synthase subunit FKS1p with FLTLS/PLRDP mutant at monophasic kineticsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100335(RO-09-3655 derivative | CHEMBL2371681)
Affinity DataIC50: 0.200nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100338(RO-09-3655 derivative | CHEMBL267407)
Affinity DataIC50: 0.25nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100332(RO-09-3655 derivative | CHEMBL415843)
Affinity DataIC50: 0.280nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50417554(ANIDULAFUNGIN)
Affinity DataIC50: 0.281nMAssay Description:Inhibition of Candida tropicalis T3 blood stream isolate glucan synthase subunit FKS1p with FLTLS/PLRDP mutant at monophasic kineticsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 0.296nMAssay Description:Inhibition of Candida tropicalis T19 blood stream isolate glucan synthase subunit FKS1p with FLTLS/PLRDP mutant at monophasic kineticsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 90028More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 0.306nMAssay Description:Inhibition of Candida tropicalis T3 blood stream isolate glucan synthase subunit FKS1p with FLTLS/PLRDP mutant at monophasic kineticsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of glucan synthase in Candida albicans 36082 assessed as incorporation of [3H]uridine diphosphoglucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
University of Medicine and Dentistry of New Jersey

Curated by ChEMBL
LigandPNGBDBM50417554(ANIDULAFUNGIN)
Affinity DataIC50: 0.503nMAssay Description:Inhibition of Candida tropicalis T19 blood stream isolate glucan synthase subunit FKS1p with FLTLS/PLRDP mutant at monophasic kineticsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100333(RO-09-3655 derivative | CHEMBL2371765)
Affinity DataIC50: 0.630nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100331(RO-09-3655 derivative | CHEMBL2371715)
Affinity DataIC50: 0.830nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50417554(ANIDULAFUNGIN)
Affinity DataIC50: 0.877nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 90028More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50417554(ANIDULAFUNGIN)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of glucan synthase in Candida albicans 36082 assessed as incorporation of [3H]uridine diphosphoglucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100329(RO-09-3655 derivative | CHEMBL2371727)
Affinity DataIC50: 0.890nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 36082More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100337(RO-09-3655 derivative | CHEMBL2371766)
Affinity DataIC50: 0.900nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
TBA

Curated by ChEMBL
LigandPNGBDBM50289910(1N-[21-(2-aminoethoxy)-3-(3-amino-1-hydroxypropyl)...)
Affinity DataIC50: 1nMAssay Description:Inhibition of 1,3-beta-glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 90028 in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of glucan synthase in Candida albicans 36082 assessed as incorporation of [3H]uridine diphosphoglucose in presence of 10% serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50366679(MK-991 | CHEMBL1793852)
Affinity DataIC50: 1.30nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100336(RO-09-3655 derivative | CHEMBL405487)
Affinity DataIC50: 1.40nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
TBA

Curated by ChEMBL
LigandPNGBDBM50289923(1N-[21-(2-aminoethoxy)-3-[3-(1,4-diaminobutylcarbo...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of 1,3-beta-glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of glucan synthase in Candida albicans 36082 assessed as incorporation of [3H]uridine diphosphoglucose in presence of 20% serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50096797(macrocyclic lipopeptidolactone derivative | CHEMBL...)
Affinity DataIC50: 2nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase (GS) from candida albicansMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 90028 in presence of 20% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 36082 in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
TBA

Curated by ChEMBL
LigandPNGBDBM50289914(1N-[21-(2-aminoethoxy)-3-[3-(1,5-diaminopentylcarb...)
Affinity DataIC50: 3nMAssay Description:Inhibition of 1,3-beta-glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

Target1,3-beta-glucan synthase(Yeast)
TBA

Curated by ChEMBL
LigandPNGBDBM50289922(1N-[3-[3-(1,4-diaminobutylcarboxamido)-1-hydroxypr...)
Affinity DataIC50: 3nMAssay Description:Inhibition of 1,3-beta-glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100334(RO-09-3655 derivative | CHEMBL407924)
Affinity DataIC50: 3.60nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
TBA

Curated by ChEMBL
LigandPNGBDBM50289924(1N-[21-(2-aminoethoxy)-3-[3-(1,2-diaminoethylcarbo...)
Affinity DataIC50: 4nMAssay Description:Inhibition of 1,3-beta-glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50417554(ANIDULAFUNGIN)
Affinity DataIC50: 4.14nMAssay Description:Inhibition of glucan synthase in Candida albicans 36082 assessed as incorporation of [3H]uridine diphosphoglucose in presence of 10% serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50417554(ANIDULAFUNGIN)
Affinity DataIC50: 4.14nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 90028 in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase component GSC2(Baker's yeast)
Leiden University

Curated by ChEMBL
LigandPNGBDBM97255(2-[(1-bromo-2-naphthalenyl)oxy]-N-(3-pyridinyl)ace...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to Kv11.1 channel (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50285488(1N-[23-[1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-20...)
Affinity DataIC50: 5nMAssay Description:Tested for inhibition of Beta-1,3-glucan synthase using a crude membrane of Candida albicans (MY 1208).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50096795(Macrocyclic lipopeptidolactone derivative | CHEMBL...)
Affinity DataIC50: 5nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase (GS) from candida albicansMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 36082 in presence of 20% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50096793(macrocyclic lipopeptidolactone derivative | CHEMBL...)
Affinity DataIC50: 6nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase (GS) from candida albicansMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
TBA

Curated by ChEMBL
LigandPNGBDBM50289917(1N-[21-(2-aminoethoxy)-3-[3-(1,3-diaminopropylcarb...)
Affinity DataIC50: 6nMAssay Description:Inhibition of 1,3-beta-glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of glucan synthase in Candida albicans 36082 assessed as incorporation of [3H]uridine diphosphoglucose in presence of 50% serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 90028 in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of FKS1 from Candida krusei 98 isolateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50285491(10,12-Dimethyl-tetradecanoic acid [6-[1,2-dihydrox...)
Affinity DataIC50: 7nMAssay Description:Tested for inhibition of Beta-1,3-glucan synthase using a crude membrane of Candida albicans (MY 1208).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50285479(10,12-Dimethyl-tetradecanoic acid [6-[1,2-dihydrox...)
Affinity DataIC50: 7nMAssay Description:Tested for inhibition of Beta-1,3-glucan synthase using a crude membrane of Candida albicans (MY 1208).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target1,3-beta-glucan synthase(Yeast)
TBA

Curated by ChEMBL
LigandPNGBDBM50503151(CHEMBL4450420)
Affinity DataIC50: 7.90nMAssay Description:Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in 3 uM glycine/glutamate-induced intracellular ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50096799(macrocyclic lipopeptidolactone derivative | CHEMBL...)
Affinity DataIC50: 8nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase (GS) from candida albicansMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478216(CHEBI:600520 | Micafungin | Mycamine)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 36082More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100339(FR-901469 | Lipopeptidolactone FR901469 | FR901469...)
Affinity DataIC50: 8.5nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
Target1,3-beta-glucan synthase(Yeast)
Public Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50478215(CHEBI:474180 | Cancidas | Caspofungin | Caspofungi...)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of glucan synthase in Candida albicans ATCC 36082 in presence of 50% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
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