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Report error Found 143 Enz. Inhib. hit(s) with Target = 'Atrial natriuretic peptide receptor 1'
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254061(CHEMBL4089530)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1/2/3(Human)
G. D. Searle

Curated by ChEMBL
LigandPNGBDBM50228173(CHEMBL2371607)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against guanylate cyclase coupled receptor binding site in rabbit lung by using [125I]-ANP-(103-126)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254062(CHEMBL4060314)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254085(CHEMBL4097040)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254084(CHEMBL4087769)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50333671(CHEMBL1643388)
Affinity DataIC50: 6nMAssay Description:Displacement of [125I]ANP from NPR-A expressed in HeLa cells after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254083(CHEMBL4076102)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50333672(CHEMBL1643389)
Affinity DataIC50: 60nMAssay Description:Displacement of [125I]ANP from NPR-A expressed in HeLa cells after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254082(CHEMBL4073884)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50333673(CHEMBL1643390)
Affinity DataIC50: 240nMAssay Description:Displacement of [125I]ANP from NPR-A expressed in HeLa cells after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254098(CHEMBL4098363)
Affinity DataIC50: 120nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254063(CHEMBL4102000)
Affinity DataIC50: 0.0940nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254106(CHEMBL4084160)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254091(CHEMBL4061318)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254105(CHEMBL4076901)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254088(CHEMBL4088351)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254087(CHEMBL4075426)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254099(CHEMBL4092707)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254092(CHEMBL4062458)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254089(CHEMBL4081715)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254086(CHEMBL4076700)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254107(CHEMBL4105659)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254094(CHEMBL4076904)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254093(CHEMBL4071568)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50631618(CHEMBL5420260)
Affinity DataIC50: 3.91E+3nMAssay Description:Inhibition of [125I]-VEGF-A165 binding to NPR1 (unknown origin) transfected in HUVECs incubated for 2 hrs by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50631619(CHEMBL5441104)
Affinity DataIC50: 6.33E+3nMAssay Description:Inhibition of [125I]-VEGF-A165 binding to NPR1 (unknown origin) transfected in HUVECs incubated for 2 hrs by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254096(CHEMBL4099663)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50631617(CHEMBL5440517)
Affinity DataIC50: 850nMAssay Description:Inhibition of [125I]-VEGF-A165 binding to NPR1 (unknown origin) transfected in HUVECs incubated for 2 hrs by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254108(CHEMBL4062470)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50313491((S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido...)
Affinity DataIC50: 2.91E+3nMAssay Description:Inhibition of [125I]-VEGF-A165 binding to NPR1 (unknown origin) transfected in HUVECs incubated for 2 hrs by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254081(CHEMBL4103929)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50631620(CHEMBL5403761)
Affinity DataIC50: 8.94E+3nMAssay Description:Inhibition of [125I]-VEGF-A165 binding to NPR1 (unknown origin) transfected in HUVECs incubated for 2 hrs by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50631621(CHEMBL5399483)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of [125I]-VEGF-A165 binding to NPR1 (unknown origin) transfected in HUVECs incubated for 2 hrs by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254095(CHEMBL4084171)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254060(CHEMBL4061379)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-human ANP from human NPR-1 incubated for 2 hrs by top count methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452474(CHEMBL4217523)
Affinity DataEC50:  900nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230988(CHEMBL4089697)
Affinity DataEC50:  8.10nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452464(CHEMBL4212125)
Affinity DataEC50:  320nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50230986(Carperitide | SUN-4936)
Affinity DataEC50:  1nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452473(CHEMBL4205804)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50230989(CHEMBL4092093)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452475(CHEMBL4218179)
Affinity DataEC50:  41nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50230988(CHEMBL4089697)
Affinity DataEC50:  76nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452476(CHEMBL4206902)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452469(CHEMBL4210169)
Affinity DataEC50:  270nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50230984(CHEMBL4099832)
Affinity DataEC50:  23nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2019
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452475(CHEMBL4218179)
Affinity DataEC50:  330nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50452463(CHEMBL4206328)
Affinity DataEC50:  780nMAssay Description:Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452471(CHEMBL4214562)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAtrial natriuretic peptide receptor 1(Rat)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452468(CHEMBL4205090)
Affinity DataEC50:  290nMAssay Description:Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
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