Compile Data Set for Download or QSAR
Report error Found 256 Enz. Inhib. hit(s) with Target = 'Bcl-2-like protein 2'
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Bcl-wMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-w (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50653011(CHEMBL5712050)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50162797(CHEMBL3793424)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50030754(CHEMBL3342332)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50030754(CHEMBL3342332)
Affinity DataKi:  19nMAssay Description:Binding affinity to BCL-W (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM333146(US10196404, Example 1 | Compound I | US10196404, E...)
Affinity DataIC50: 20nMAssay Description:Inhibition of N-terminal His6-tagged Bcl-w (1 to 171 residues) (unknown origin) expressed in Escherichia coli using biotin-labeled Bim peptide GGMRPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50270877(ABT-263 | (R)-4-(4-((2-(4-chlorophenyl)-5,5-dimeth...)
Affinity DataKi:  21nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50357756(CHEMBL1916194)
Affinity DataKi:  21nMAssay Description:Displacement of BODIPY-Bak conjugated peptide from GST-tagged human wild type Bcl-W expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataIC50: 40nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-w by solution competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM32274(cid_1002249 | SMR000115103 | 2,5-dichloro-3-(4-met...)
Affinity DataEC50:  40nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM21434(N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)b...)
Affinity DataKi:  49nMAssay Description:Displacement of BODIPY-Bak conjugated peptide from GST-tagged human wild type Bcl-W expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM33066(cid_1002248 | 2,5-dichloro-3-[2-(dimethylamino)-5-...)
Affinity DataEC50:  50nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50357753(CHEMBL1916191)
Affinity DataKi:  55nMAssay Description:Displacement of BODIPY-Bak conjugated peptide from GST-tagged human wild type Bcl-W expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50357755(CHEMBL1916193)
Affinity DataKi:  59nMAssay Description:Displacement of BODIPY-Bak conjugated peptide from GST-tagged human wild type Bcl-W expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50020938(CHEMBL3287301)
Affinity DataKd:  62nMAssay Description:Binding affinity to Bcl-w (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50357752(CHEMBL1916190)
Affinity DataKi:  63nMAssay Description:Displacement of BODIPY-Bak conjugated peptide from GST-tagged human wild type Bcl-W expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataIC50: 66nMpH: 7.4Assay Description:The protocols for tight and weak binders were described in Biacore S51 assay set-up with a flow rate of 30 µL/min. For His-Bcl-2 protein assays...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2014
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataIC50: 66nMAssay Description:Binding affinity to Bcl-w (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50270877(ABT-263 | (R)-4-(4-((2-(4-chlorophenyl)-5,5-dimeth...)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human N-terminal 6xHis-tagged Bcl-w (M1 to R171) expressed in Escherichia coli using HyLite Fluor 647-labeled Bim peptide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM33107(2-chloro-3-{[4-(diethylamino)phenyl]amino}naphthoq...)
Affinity DataEC50:  170nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50357754(CHEMBL1916192)
Affinity DataKi:  170nMAssay Description:Displacement of BODIPY-Bak conjugated peptide from GST-tagged human wild type Bcl-W expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50339779(N-{7-[4-(4'-Chloro-biphenyl-2-ylmethyl)piperazin-1...)
Affinity DataIC50: 245nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-w by solution competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi:  245nMAssay Description:Binding affinity to Bcl-w (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi:  245nMAssay Description:Displacement of fluorescent-labeled BID-BH3 peptide from human BCL-W expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi:  245nMAssay Description:Binding affinity to Bcl-w (unknown origin) assessed as inhibition constant by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi:  245nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi:  245nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50270877(ABT-263 | (R)-4-(4-((2-(4-chlorophenyl)-5,5-dimeth...)
Affinity DataKi:  245nMAssay Description:Inhibition of BCL-W (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50339783(N-(7-{4-[2-(4-Chloro-phenyl)-5,5-dimethyl-cyclohex...)
Affinity DataIC50: 275nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-w by solution competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi:  285nMAssay Description:Inhibition of Bcl-w (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM32318(cid_5337459 | 4-[[4-(2-methyl-3-imidazo[1,2-a]pyri...)
Affinity DataEC50:  330nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50339777((R)-N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)pipera...)
Affinity DataIC50: 440nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-w by solution competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM21400(N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)b...)
Affinity DataKd:  459nMAssay Description:Binding affinity to BclwMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM451097(US10676485, Example 7)
Affinity DataKi: >468nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM32284(cid_5514357 | (6E)-2-methoxy-6-[([1,2,4]triazolo[3...)
Affinity DataEC50:  490nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50339781(N-(7-{4-[2-(4-Chloro-phenyl)-5,5-dimethyl-cyclohex...)
Affinity DataIC50: 540nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-w by solution competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM109236(WEHI-539)
Affinity DataIC50: 4.10E+3nM Kd: >550nMpH: 7.4Assay Description:The protocols for tight and weak binders were described in Biacore S51 assay set-up with a flow rate of 30 µL/min. For His-Bcl-2 protein assays...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2014
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM33048(MLS000089998 | 5-[4-(dimethylamino)phenyl]imino-1-...)
Affinity DataEC50:  550nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM33097(MLS000521052 | cid_11957209 | 3-[[7-(1,3-benzothia...)
Affinity DataEC50:  620nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50078160(CHEMBL3417701)
Affinity DataKi: >660nMAssay Description:Inhibition of BCL-W (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM32328(MLS000674601 | cid_16195481 | SMR000314043 | 4-{2-...)
Affinity DataEC50:  670nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM356652(trans-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcycloh...)
Affinity DataKi:  852nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM33102(N-ethyl-N-(1-hydroxy-3,4-dioxo-2-naphthalenyl)prop...)
Affinity DataEC50:  920nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50339776(N-(7-{4-[2-(4-Chloro-phenyl)-5,5-dimethyl-cyclohex...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-w by solution competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50339782(N-(7-{4-[2-(4-Chloro-phenyl)-5,5-dimethyl-cyclohex...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-w by solution competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50529037(CHEMBL4592905)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal 6xHis-tagged Bcl-w (M1 to R171) expressed in Escherichia coli using HyLite Fluor 647-labeled Bim peptide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50376902(CHEMBL408194)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of BH3 peptide binding to human recombinant BCL-w by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50339778(N-{7-[4-(4'-Chloro-biphenyl-2-ylmethyl)piperazin-1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-w by solution competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50339780(N-{7-[4-(4'-Chloro-biphenyl-2-ylmethyl)piperazin-1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of wild type mBimBH3 from human Bcl-w by solution competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
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