Compile Data Set for Download or QSAR
Report error Found 3230 Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 2'
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [125I]MCP1 from CCR2/CXCR4 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50035696(AMD-3100 | CHEMBL18442 | 11-{4-[4,8, 11-1,4,8,11te...)
Affinity DataIC50: 0.0400nMAssay Description:Displacement of [125I]SDF1alpha from CCR2/CXCR4 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125I]SDF1alpha from CCR2/CXCR4 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50035696(AMD-3100 | CHEMBL18442 | 11-{4-[4,8, 11-1,4,8,11te...)
Affinity DataIC50: 0.0900nMAssay Description:Displacement of [125I]MCP1 from CCR2/CXCR4 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50257994((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl )-1-isop...)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells by chemotaxis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50257994((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl )-1-isop...)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells by chemotaxis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50257994((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl )-1-isop...)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells by chemotaxis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50212136((1S,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]met...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of chemotaxis in human MCP1 monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50009220(CHEMBL3233186)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at CCR2 in human monocytes assessed as reduction of chemotaxis in presence of 0.1 M BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50268371(N-(2-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-((4-...)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50009224(CHEMBL3233188)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at CCR2 in human monocytes assessed as reduction of chemotaxis in presence of 0.1 M BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50377038(CHEMBL258205)
Affinity DataIC50: 0.200nMAssay Description:Binding affinity at human CCR2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50212127((1S,3R)-1-cyclopropyl-N-{[3-fluoro-5-(trifluoromet...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of chemotaxis in human MCP1 monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50089354(CHEMBL3577945)
Affinity DataIC50: 0.240nMAssay Description:Antagonist activity against CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis at 37 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50012008(CHEMBL3263286)
Affinity DataIC50: 0.25nMAssay Description:Displacement of labeled MCP-1 from human CCR2 expressed in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataIC50: 0.25nMAssay Description:Displacement of [125I]MCP1 from CCR2 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50257995((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3-et...)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at human CCR2 receptor expressed in CHO cells by chemotaxis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50268423(N-(2-((1S,2R,4R)-4-(dimethylamino)-2-((4-(methylth...)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50557876(CHEMBL4764460)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as reduction in MCP1-induced chemotaxis measured after 30 mins by calcein-AM dye based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50315998(N-((S)-1-((1S,2R,4R)-4-(ethyl(isopropyl)amino)-2-(...)
Affinity DataIC50: 0.300nMAssay Description:Displacement of [125I]-MCP1 from CCR2 in human THP1 cells after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50212128((1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]met...)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of chemotaxis in human MCP1 monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50009220(CHEMBL3233186)
Affinity DataIC50: 0.340nMAssay Description:Displacement of [125I]-labeled human MCP1 from CCR2 in human PBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50268423(N-(2-((1S,2R,4R)-4-(dimethylamino)-2-((4-(methylth...)
Affinity DataIC50: 0.370nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC by millipore filter plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50506124(CHEMBL4544504)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from human CCR2 expressed in human U2OS cells incubated for 2 hrs by scintillation spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50089366(CHEMBL3577948)
Affinity DataIC50: 0.400nMT: 2°CAssay Description:Inhibition of [125I]hMCP1 binding to CCR2 in human PBMC incubated for 30 mins at room temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50315992(N-((S)-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-...)
Affinity DataIC50: 0.400nMAssay Description:Displacement of [125I]-MCP1 from CCR2 in human THP1 cells after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50506124(CHEMBL4544504)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from human CCR2 expressed in human U2OS cells incubated for 2 hrs by scintillation spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50509862(CHEMBL4457723)
Affinity DataIC50: 0.400nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50198149((S)-1-(4-(1-(3,5-bis(trifluoromethyl)benzylamino)-...)
Affinity DataIC50: 0.430nMAssay Description:Antagonist activity at human CCR2b receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50198149((S)-1-(4-(1-(3,5-bis(trifluoromethyl)benzylamino)-...)
Affinity DataIC50: 0.430nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50506145(CHEMBL4483373)
Affinity DataKi:  0.447nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from human CCR2 expressed in human U2OS cells incubated for 2 hrs by scintillation spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50506145(CHEMBL4483373)
Affinity DataKi:  0.447nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from human CCR2 expressed in human U2OS cells incubated for 2 hrs by scintillation spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50089355(CHEMBL3577932)
Affinity DataIC50: 0.450nMAssay Description:Antagonist activity against CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis at 37 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50089356(CHEMBL3577933)
Affinity DataIC50: 0.450nMAssay Description:Antagonist activity against CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis at 37 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50077906(CHEMBL3305901)
Affinity DataKd:  0.480nMAssay Description:Displacement of 0.1 nM [125I]CCL2 from human CCR2 expressing human U2OS cell membrane by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50382932(CHEMBL2029422)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of CCR2-mediated Erk phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50371414(CHEMBL271828)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human CCR2 in PBMCs assessed as inhibition of chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50315993(N-((S)-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at CCR2 in human monocytes assessed as reduction of chemotaxis in presence of 0.1 M BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50268371(N-(2-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-((4-...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50315993(N-((S)-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis after 45 mins in presence of 0.1 M bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50009221(CHEMBL3233187)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I]-labeled human MCP1 from CCR2 in human PBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50089364(CHEMBL3577946)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity against CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis at 37 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50089364(CHEMBL3577946)
Affinity DataIC50: 0.5nMT: 2°CAssay Description:Inhibition of [125I]hMCP1 binding to CCR2 in human PBMC incubated for 30 mins at room temperatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50077906(CHEMBL3305901)
Affinity DataKi:  0.550nMAssay Description:Displacement of 0.1 nM [125I]CCL2 from human CCR2 expressing human U2OS cell membrane by scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50089353(CHEMBL3577942)
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity against CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis at 37 degCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50557877(CHEMBL4790208)
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as reduction in MCP1-induced chemotaxis measured after 30 mins by calcein-AM dye based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50009217(CHEMBL3233184)
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at CCR2 in human monocytes assessed as reduction of chemotaxis in presence of 0.1 M BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50377034(CHEMBL256301)
Affinity DataIC50: 0.600nMAssay Description:Binding affinity at human CCR2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50428327(CHEMBL2338392)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human THP1 cell membranes after 8 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50198115(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(2-ac...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of MCP1-stimulated chemotaxis in monocytes transfected with human CCR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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