Compile Data Set for Download or QSAR
Report error Found 876 Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 4'
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278725(CHEMBL4172769)
Affinity DataIC50: 0.316nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278758(CHEMBL4167445)
Affinity DataIC50: 0.631nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataKi:  0.794nMAssay Description:Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278799(CHEMBL4162364)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500893(CHEMBL3797662)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at mouse CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500901(CHEMBL3799266)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500908(CHEMBL3797537)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278793(CHEMBL4160218)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50175665((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50198429((S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]py...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataKi:  3.16nMAssay Description:Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Dog)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at dog CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataKi:  3.20nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500894(CHEMBL3799578)
Affinity DataKi:  3.20nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.89nMAssay Description:Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278794(CHEMBL4175323)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278797(CHEMBL4160846)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500902(CHEMBL3798452)
Affinity DataKi:  4nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278727(CHEMBL4173046)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50378979(CHEMBL2011441)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at mouse CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500896(CHEMBL3799393)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50545768(CHEMBL4641127)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500896(CHEMBL3799393)
Affinity DataEC50:  6.30nMAssay Description:Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50490519(CHEMBL2326625)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50490515(CHEMBL2326611)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50490519(CHEMBL2326625)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50198429((S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]py...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM236789(US9388149, 20 | US9580412, Example 20)
Affinity DataIC50: 7.20nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500893(CHEMBL3797662)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278801(CHEMBL4165356)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500894(CHEMBL3799578)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50175665((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500901(CHEMBL3799266)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278787(CHEMBL4173861)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380879(CHEMBL2018968)
Affinity DataKi:  7.94nMAssay Description:Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50545779(CHEMBL4642563)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM236788(US9388149, 19 | US9580412, Example 19)
Affinity DataIC50: 8.10nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50545782(CHEMBL4637695)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM236791(US9388149, 22 | US9580412, Example 22)
Affinity DataIC50: 9.40nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
Go to US Patent

TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380880(CHEMBL2018969)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
Displayed 1 to 50 (of 876 total ) | Next | Last >>
Jump to: