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Report error Found 5212 Enz. Inhib. hit(s) with Target = 'CREB-binding protein'
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM188516(BDOIA383)
Affinity DataKd:  120nMAssay Description:Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM188517(PF-CBP1)
Affinity DataKd:  190nMAssay Description:Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM188519(SGC-CBP30)
Affinity DataKd:  21nMAssay Description:Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50249042(CHEMBL4087272)
Affinity DataKd:  8.50E+4nMAssay Description:Binding affinity to partial length human DNA-tagged CBP (R1081 to G1197 residues) expressed in bacterial expression system by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50249043(CHEMBL4077137)
Affinity DataKd:  4.00E+3nMAssay Description:Binding affinity to partial length human DNA-tagged CBP (R1081 to G1197 residues) expressed in bacterial expression system by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50250892(CHEMBL4061254 | US10696655, Example 63 | US1116807...)
Affinity DataEC50:  53nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
LigandPNGBDBM50250911(CHEMBL4095153 | US10696655, Example 45 | US1116807...)
Affinity DataEC50:  12nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
LigandPNGBDBM50250896(CHEMBL4065346 | US10696655, Example 52 | US1116807...)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
LigandPNGBDBM50250910(CHEMBL4072630 | US10696655, Example 18 | US1116807...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
LigandPNGBDBM50250913(CHEMBL4073812 | US10696655, Example 67 | US1116807...)
Affinity DataEC50:  360nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2019
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50148603(CHEMBL3770724)
Affinity DataKd:  3.30E+4nMAssay Description:Inhibition of poly-His tagged CREBBP (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50269849(CHEMBL4076748)
Affinity DataEC50:  14nMAssay Description:Inhibition of CBP in human MV-4-11 cells assessed as decrease in MYC expression incubated for 4 hrs measured by luminescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50200445(CHEMBL3897393 | US9763922, Example 300)
Affinity DataEC50:  910nMAssay Description:Inhibition of CBP in human MV-4-11 cells assessed as decrease in MYC expression incubated for 4 hrs measured by luminescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50269847(CHEMBL4097025)
Affinity DataEC50:  6.60nMAssay Description:Inhibition of CBP in human MV-4-11 cells assessed as decrease in MYC expression incubated for 4 hrs measured by luminescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50366670(CHEMBL4173488)
Affinity DataKd:  47nMAssay Description:Binding affinity to human CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM179481(US9675697, Cpd. No. 73)
Affinity DataKd:  520nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453948(CHEMBL4204490 | US11247989, Example 96)
Affinity DataEC50:  76nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataKd:  0.230nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataEC50:  32nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50453970(CHEMBL4207965 | US11247989, Example 98)
Affinity DataEC50:  110nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453971(CHEMBL4204065 | US11247989, Example 11)
Affinity DataEC50:  280nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataEC50:  18nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453957(CHEMBL4217213)
Affinity DataEC50:  6.60nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50453976(CHEMBL4209361 | US11247989, Example 97)
Affinity DataEC50:  220nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged CREBBP expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50459788(CHEMBL4213403)
Affinity DataKd:  1.40E+3nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length CBP bromodomain (R1081 to G1197 residues) expressed in bacteria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50459789(CHEMBL4206088)
Affinity DataKd:  970nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length CBP bromodomain (R1081 to G1197 residues) expressed in bacteria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50459792(CHEMBL4206032)
Affinity DataKd:  85nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length CBP bromodomain (R1081 to G1197 residues) expressed in bacteria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50459794(CHEMBL4218324)
Affinity DataKd:  4.00E+3nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length CBP bromodomain (R1081 to G1197 residues) expressed in bacteria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50459795(CHEMBL4210443)
Affinity DataKd:  3nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length CBP bromodomain (R1081 to G1197 residues) expressed in bacteria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50459796(CHEMBL4210917)
Affinity DataKd:  2.00E+4nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length CBP bromodomain (R1081 to G1197 residues) expressed in bacteria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50459793(CHEMBL4205572)
Affinity DataKd:  35nMAssay Description:Displacement of biotinylated acetylated peptide from poly His-tagged CBP bromodomain (unknown origin) expressed in Escherichia coli BL21(DE3) measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50459799(CHEMBL4217805)
Affinity DataKd:  1.40E+3nMAssay Description:Displacement of biotinylated acetylated peptide from recombinant human partial length CBP bromodomain (R1081 to G1197 residues) expressed in bacteria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM249277(US9458145, 1020-18 | US10017501, Compound 1020-18)
Affinity DataKd:  170nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system after 1 hr by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50517156(CHEMBL4559894)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50517166(CHEMBL4527581)
Affinity DataKd:  7.80E+4nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50459793(CHEMBL4205572)
Affinity DataKd:  35nMAssay Description:Binding affinity to Poly-Histidine-tagged CBP (unknown origin) expressed in Escherichia coli BL21(DE3) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50520333(CHEMBL4464525)
Affinity DataKd:  5.30E+4nMAssay Description:Binding affinity to Poly-Histidine-tagged CBP (unknown origin) expressed in Escherichia coli BL21(DE3) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to recombinant CBP (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50527820(CHEMBL4549898)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to recombinant CBP (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50527821(CHEMBL4455209)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to recombinant CBP (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataKd:  9.60E+3nMAssay Description:Binding affinity to recombinant CBP (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50527823(CHEMBL4517875)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to recombinant CBP (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50103503(CHEMBL2393130 | US11117865, Compound RVX-208 | US2...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to recombinant CBP (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50539801(CHEMBL4648912 | US11840533, Compound 70)
Affinity DataKd: <1nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50553559(CHEMBL4795699)
Affinity DataKd:  2.54E+4nMAssay Description:Binding affinity to CBP BRD (unknown origin) by microscale thermophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50559467(CHEMBL4763016)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  8.30E+4nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50238255(CHEMBL3753333)
Affinity DataKd:  320nMAssay Description:Binding affinity to human CBP by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM50562129(CHEMBL4754613)
Affinity DataKd:  28nMAssay Description:Binding affinity to human CBP by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
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