Compile Data Set for Download or QSAR
Report error Found 655 Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 12'
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50642423(CHEMBL5567321)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50642414(CHEMBL5573550)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50642431(CHEMBL5575019)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50642413(CHEMBL5573404)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50642427(CHEMBL5572601)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50642432(CHEMBL5571201)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM478960(2-(1'-cyano-1',2',3',6'-tetrahydro-[2,4'-bipyridin...)
Affinity DataIC50: 4nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM478959(2-(1'-cyano-1',2',5',6'-tetrahydro-[2,3'-bipyridin...)
Affinity DataIC50: 6nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM706362(US20240383900, Compound PPA-024)
Affinity DataIC50: 6nMAssay Description:A radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 7nMAssay Description:Inhibition of GST-tagged human CDK12/Cyclin K expressed in Sf9 cells using RBER-IRStide peptide as substrate in presence of ATP and [gamma33-P] ATP b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50642418(CHEMBL5573275)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM478942(US10894786, Comp. No 44 | US10894786, Comp. No 45 ...)
Affinity DataIC50: 9nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50646415(CHEMBL5595312)
Affinity DataEC50:  9nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM478951(2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridi...)
Affinity DataIC50: 10nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50642419(CHEMBL5571531)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50553482(Tp-1287)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM706422(US20240383900, Compound PPA-086)
Affinity DataIC50: 11nMAssay Description:A radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM478958(N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(6-(1-propiolo...)
Affinity DataIC50: 12nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataEC50:  12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM706428(US20240383900, Compound PPA-092)
Affinity DataIC50: 13nMAssay Description:A radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50367857(CHEMBL4159417)
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50540077(CHEMBL4649135)
Affinity DataIC50: 14nMAssay Description:Inhibition of GST-tagged recombinant human CDK12 (696 to 1082 residues) expressed in Insect cell in presence of ATP by Km ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM478940(2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-yl)-3...)
Affinity DataIC50: 14nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50644788(CHEMBL5573487)
Affinity DataEC50:  15nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM729445(N-(5-(3-(2-chlorobenzyl)-1-((1r,4S)-4-((5-cyanopyr...)
Affinity DataIC50: 15nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM729453(N-(5-(3-benzyl-1-((1r,4S)-4-((5-cyanopyridin-2-yl)...)
Affinity DataIC50: 15nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50583918(CHEMBL4791134)
Affinity DataIC50: 15nMAssay Description:Inhibition of CDK12/cyclin K (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50367676(CHEMBL4160662)
Affinity DataKd:  16nMAssay Description:Binding affinity to human CDK12 (715 to 1052 residues)/CyclinK (1 to 267 residues) expressed in baculovirus infected in Sf9 cells by Biolayer interfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50154937(CHEMBL518800)
Affinity DataEC50:  16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50466842(CHEMBL1615221)
Affinity DataEC50:  16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50378235(CHEMBL461557)
Affinity DataEC50:  17nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50642422(CHEMBL5574515)
Affinity DataIC50: 18nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM706400(US20240383900, Compound PPA-064)
Affinity DataIC50: 18nMAssay Description:A radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50644794(CHEMBL5575551)
Affinity DataEC50:  18nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50528812(CHEMBL4582951)
Affinity DataIC50: 20nMAssay Description:Competitive irreversible inhibition of CDK12/cyclinK (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50644790(CHEMBL5575056)
Affinity DataEC50:  21nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50644795(CHEMBL5594035)
Affinity DataEC50:  21nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50642421(CHEMBL5562669)
Affinity DataIC50: 22nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM706354(US20240383900, Compound PPA-016)
Affinity DataIC50: 22nMAssay Description:A radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50625575(CHEMBL5414905)
Affinity DataIC50: 22nMAssay Description:Inhibition of GST-tagged recombinant human CDK12 (696 to 1082 residues) expressed in Insect cell in presence of ATP by Km ATP assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50642406(CHEMBL5572804)
Affinity DataIC50: 22nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM706410(US20240383900, Compound PPA-074)
Affinity DataIC50: 23nMAssay Description:A radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM706426(US20240383900, Compound PPA-090)
Affinity DataIC50: 23nMAssay Description:A radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM478947(2-(1'-acryloyl-1',2',5',6'-tetrahydro-[2,3'-bipyri...)
Affinity DataIC50: 23nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM706421(US20240383900, Compound PPA-085)
Affinity DataIC50: 23nMAssay Description:A radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50583916(CHEMBL4786320)
Affinity DataIC50: 24nMAssay Description:Inhibition of CDK12/cyclin K (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM478422((S)-2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-y...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

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