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Report error Found 1252 Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 2-alpha'
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50280960(9-(3,4-Dimethoxy-phenyl)-8H-furo[3',4':6,7]naphtho...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50633982(CHEBI:42053 | NEMORUBICIN)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM58490(SMR000466355 | (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM43839(Acid, 8)
Affinity DataIC50: 3nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142519(N-[2-(3,4,5-triihydroxy-benzoylamino)-phenyl]-3,4,...)
Affinity DataIC50: 9nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataIC50: 10nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470378(CHEMBL108283)
Affinity DataIC50: 20nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 26nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataEC50:  30nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 41nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470365(CHEMBL326664)
Affinity DataIC50: 45nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  54nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470374(CHEMBL322325)
Affinity DataIC50: 54nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  56nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50123623((R)-13-(3-aminopyrrolidin-1-yl)-12-fluoro-10-oxo-1...)
Affinity DataIC50: 60nMAssay Description:Induction of poison effect at DNA topoisomerase 2 by G-quadruplex interaction polymerase stop assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470371(CHEMBL325543)
Affinity DataIC50: 63nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50489101(CHEMBL2296491)
Affinity DataIC50: 76nMAssay Description:Inhibition of DNA topoisomerase 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213799(CHEMBL440642)
Affinity DataEC50:  96nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213803(CHEMBL428339)
Affinity DataEC50:  98nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470361(CHEMBL108404)
Affinity DataIC50: 116nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 124nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50489098(CHEMBL2296492)
Affinity DataIC50: 125nMAssay Description:Inhibition of DNA topoisomerase 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50489096(CHEMBL2296490)
Affinity DataIC50: 132nMAssay Description:Inhibition of DNA topoisomerase 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142517(N-[4-(3,4,5-triihydroxy-benzoylamino)-phenyl]-3,4,...)
Affinity DataIC50: 150nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213805(CHEMBL7877)
Affinity DataEC50:  160nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213812(CHEMBL269139)
Affinity DataEC50:  160nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50505835(CHEMBL4463643)
Affinity DataIC50: 200nMAssay Description:Inhibition of human topoisomerase 2alpha mediated decatenation using kDNA as susbtrate preincubated for 20 mins followed by substrate and ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50142507(N-[3-(3,4,5-triihydroxy-benzoylamino)-phenyl]-3,4,...)
Affinity DataIC50: 220nMAssay Description:Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470369(CHEMBL325588)
Affinity DataIC50: 226nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50525581(CHEMBL4469453)
Affinity DataIC50: 230nMAssay Description:Inhibition of DNA topoisomerase 2 in human MCF7 cells incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50471898(CHEMBL135778)
Affinity DataIC50: 240nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50214091(CHEMBL27233)
Affinity DataEC50:  330nMAssay Description:In vitro evaluation for inhibitor of human topoisomerase II from HeLa cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213795(CHEMBL268458)
Affinity DataEC50:  330nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50214091(CHEMBL27233)
Affinity DataEC50:  330nMAssay Description:Inhibition of topoisomerase II purified from HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2018
Entry Details

TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50487880(CHEMBL2260090)
Affinity DataIC50: 350nMAssay Description:Inhibition of Homo sapiens (human) topoisomerase 2 assessed as decatenation of KDNA by agarose gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50213794(CHEMBL7690)
Affinity DataEC50:  360nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2018
Entry Details

TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataIC50: 390nMAssay Description:Inhibition of Homo sapiens (human) DNA topoisomerase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetDNA topoisomerase 2-alpha(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM50633983(Aconitine | Aconitinum | NSC-56464 | NSC-759627 | ...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Topo IIalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50471897(CHEMBL137098)
Affinity DataIC50: 420nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50525582(CHEMBL4470431)
Affinity DataIC50: 440nMAssay Description:Inhibition of DNA topoisomerase 2 in human MCF7 cells incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50471907(CHEMBL337526)
Affinity DataIC50: 440nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50008935(CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...)
Affinity DataIC50: 480nMAssay Description:Inhibition of DNA topoisomerase 2 in human MCF7 cells incubated for 18 to 24 hrs by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50471900(CHEMBL335700)
Affinity DataIC50: 490nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470684(CHEMBL173975)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity for 50% on topoisomerase II isolated from Giardia lambliaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50286492(2-(4-Amino-cyclohexyl)-5-cyclopropyl-7-(2,6-dimeth...)
Affinity DataEC50:  500nMAssay Description:Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50471783(CHEMBL121666)
Affinity DataEC50:  500nMAssay Description:In vitro evaluation for inhibitor of human topoisomerase II from HeLa cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50470690(CHEMBL367883)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity for 50% on topoisomerase II isolated from Giardia lambliaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
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