Compile Data Set for Download or QSAR
Report error Found 682 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit alpha-1/beta-2'
LigandPNGBDBM540734(US11261211, Compound SA-1)
Affinity DataEC50:  750nMAssay Description:This assay is not specified.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

LigandPNGBDBM540735(US11261211, Compound SA-2)
Affinity DataEC50:  750nMAssay Description:This assay is not specified.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

LigandPNGBDBM540736(US11261211, Compound SA-4)
Affinity DataEC50:  1.50E+3nMAssay Description:This assay is not specified.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

LigandPNGBDBM540737(US11261211, Compound SA-3)
Affinity DataEC50:  1.50E+3nMAssay Description:This assay is not specified.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

LigandPNGBDBM540739(US11261211, Compound SA-8)
Affinity DataEC50:  1.50E+3nMAssay Description:This assay is not specified.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

LigandPNGBDBM540741(US11261211, Compound SA-5)
Affinity DataEC50:  1.50E+3nMAssay Description:This assay is not specified.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent

LigandPNGBDBM655561(US11912737, Example 1 | US11912737, Example 7.)
Affinity DataEC50:  1.50E+3nMAssay Description:Whole cell currents were measured with HEKA EPC-10 amplifiers using PatchMaster software or by using the high throughput QPatch platform (Sophion). B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

LigandPNGBDBM655564(US11912737, Example 2 | US11912737, Example 10.)
Affinity DataEC50:  1.50E+3nMAssay Description:Whole cell currents were measured with HEKA EPC-10 amplifiers using PatchMaster software or by using the high throughput QPatch platform (Sophion). B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

LigandPNGBDBM655565(US11912737, Example 3 | US11912737, Example 11.)
Affinity DataEC50: >2.00E+3nMAssay Description:Whole cell currents were measured with HEKA EPC-10 amplifiers using PatchMaster software or by using the high throughput QPatch platform (Sophion). B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

LigandPNGBDBM669517(US20240132445, Compound Control 3)
Affinity DataEC50:  1.04E+4nMAssay Description:A whole-cell patch-clamp technique was used to study the allosteric regulation effect of the compound of the present invention on the GABAA (α1&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM669518(US20240132445, Compound 20)
Affinity DataEC50:  1.56E+3nMAssay Description:A whole-cell patch-clamp technique was used to study the allosteric regulation effect of the compound of the present invention on the GABAA (α1&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM50191342(3alpha-hydroxy-5alpha-pregnan-20-one | CHEMBL20753...)
Affinity DataEC50:  237nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50258228(CHEMBL4078922)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258239(CHEMBL4091891)
Affinity DataEC50:  1.16E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258255(CHEMBL4062424)
Affinity DataEC50:  1.64E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258256(CHEMBL3427532)
Affinity DataEC50:  125nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataEC50:  375nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258229(CHEMBL4103751)
Affinity DataEC50:  1.05E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258248(CHEMBL4084134)
Affinity DataEC50: >3.00E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258249(CHEMBL4080678)
Affinity DataEC50:  1.60E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258244(CHEMBL4100583)
Affinity DataEC50: >3.00E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258254(CHEMBL4073780)
Affinity DataEC50:  225nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258252(CHEMBL4073679)
Affinity DataEC50:  291nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258243(CHEMBL4081622)
Affinity DataEC50:  1.76E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258217(CHEMBL3427530)
Affinity DataEC50:  979nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258218(CHEMBL4103198)
Affinity DataEC50: >3.65E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258250(CHEMBL4104908)
Affinity DataEC50: >3.00E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258251(CHEMBL4072311)
Affinity DataEC50: >3.00E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258242(CHEMBL4071062)
Affinity DataEC50: >3.00E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258253(CHEMBL4085062)
Affinity DataEC50:  1.50E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50282234(CHEMBL4163464)
Affinity DataEC50:  1.23E+3nMAssay Description:Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50282235(CHEMBL4174166)
Affinity DataEC50:  500nMAssay Description:Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA chlori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50282234(CHEMBL4163464)
Affinity DataEC50:  200nMAssay Description:Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA chlori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50164570(Alfaxalone | (3R,5S,8S,9S,10S,13S,14S,17S)-17-Acet...)
Affinity DataEC50:  2.20E+3nMAssay Description:Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA chlori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50164570(Alfaxalone | (3R,5S,8S,9S,10S,13S,14S,17S)-17-Acet...)
Affinity DataEC50:  500nMAssay Description:Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50282235(CHEMBL4174166)
Affinity DataEC50:  70nMAssay Description:Positive allosteric modulation of human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from human GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataEC50:  374nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459890(CHEBI:70620 | Bromophene)
Affinity DataEC50:  720nMAssay Description:Agonist activity at recombinant human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes incubated for 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50427613(CHEMBL2322935)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50462443(CHEMBL4238315)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50462444(CHEMBL4244129)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50462446(CHEMBL4238634)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50462450(CHEMBL4238712)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50464234(CHEMBL4284872)
Affinity DataEC50: >5.00E+4nMAssay Description:Potentiation of human GABAA alpha1beta2gamma2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50481220(CHEMBL608389)
Affinity DataEC50:  1.37E+4nMAssay Description:Modulatory activity at human GABAA alpha-1-beta-2-gamma-2L receptor expressed in Xenopus laevis oocytes assessed as potentiation of of GABA EC5-induc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
LigandPNGBDBM50481221(CHEMBL595673)
Affinity DataEC50:  1.50E+4nMAssay Description:Modulatory activity at human GABAA alpha-1-beta-2-gamma-2L receptor expressed in Xenopus laevis oocytes assessed as potentiation of of GABA EC5-induc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
LigandPNGBDBM50481222(CHEMBL595422)
Affinity DataEC50:  1.22E+4nMAssay Description:Modulatory activity at human GABAA alpha-1-beta-2-gamma-2L receptor expressed in Xenopus laevis oocytes assessed as potentiation of of GABA EC5-induc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
LigandPNGBDBM50481223(CHEMBL609751)
Affinity DataEC50:  6.68E+3nMAssay Description:Modulatory activity at human GABAA alpha-1-beta-2-gamma-2L receptor expressed in Xenopus laevis oocytes assessed as potentiation of of GABA EC5-induc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
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