Compile Data Set for Download or QSAR
Report error Found 1225 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit alpha-2'
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-3/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha2beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50459889(CHEMBL4224740)
Affinity DataEC50:  7.60E+3nMAssay Description:Positive allosteric modulation of recombinant wild type GABAA receptor alpha2beta2gamma2S (unknown origin) expressed in HEK293 cells assessed as pote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459890(CHEBI:70620 | Bromophene)
Affinity DataEC50:  1.08E+3nMAssay Description:Agonist activity at recombinant human GABAA receptor alpha2beta2gamma2L expressed in Xenopus laevis oocytes incubated for 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM246487(Batatasin III (4) | US20240398793, Compound 8)
Affinity DataEC50:  8.08E+4nMAssay Description:Modulation of GABAA alpha2beta2gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of EC3 to 10 GABA-induc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50497208(CHEMBL3289196)
Affinity DataEC50:  1.48E+4nMAssay Description:Modulation of GABAA alpha2beta2gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as modulation of GABA-induced chloride ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
LigandPNGBDBM50497206(CHEMBL3289195)
Affinity DataEC50:  2.64E+4nMAssay Description:Modulation of GABAA alpha2beta2gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as modulation of GABA-induced chloride ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
LigandPNGBDBM50120774(2-(2-Fluoro-phenyl)-8-(4-methoxy-benzoyl)-6,7,8,9-...)
Affinity DataEC50:  383nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120777(8-(3-Fluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8,9-t...)
Affinity DataEC50:  70nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50001728(CHEMBL661 | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]t...)
Affinity DataEC50:  12nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120772(2-(2-Fluoro-phenyl)-8-propionyl-6,7,8,9-tetrahydro...)
Affinity DataEC50:  110nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM26266(Ambien | CHEMBL911 | ZPM | N,N-dimethyl-2-[6-methy...)
Affinity DataEC50:  737nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120789(8-Benzyl-2-(4-fluoro-phenyl)-6,7,8,9-tetrahydro-5H...)
Affinity DataEC50:  245nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120801(2-(2-Fluoro-phenyl)-8-pyrimidin-2-yl-6,7,8,9-tetra...)
Affinity DataEC50:  84nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120779(8-(4-Fluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8,9-t...)
Affinity DataEC50:  55nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120782(2-(2-Fluoro-phenyl)-8-pyridin-3-ylmethyl-6,7,8,9-t...)
Affinity DataEC50:  101nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120792(8-Benzyl-2-p-tolyl-6,7,8,9-tetrahydro-5H-1,3a,5,8-...)
Affinity DataEC50:  1.18E+3nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120775(2-(2-Fluoro-phenyl)-8-pyridin-4-ylmethyl-6,7,8,9-t...)
Affinity DataEC50:  99nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120771(8-Benzyl-2-(2-thiophen-2-yl-phenyl)-6,7,8,9-tetrah...)
Affinity DataEC50:  879nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120805(2-(2-Fluoro-phenyl)-8-propenyl-6,7,8,9-tetrahydro-...)
Affinity DataEC50:  284nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120790(8-Benzyl-2-(2,5-difluoro-phenyl)-6,7,8,9-tetrahydr...)
Affinity DataEC50:  188nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120799(8-(3,4-Difluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8...)
Affinity DataEC50:  238nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120781(8-Benzyl-2-(3-fluoro-phenyl)-6,7,8,9-tetrahydro-5H...)
Affinity DataEC50:  154nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120794(2-(2-Fluoro-phenyl)-8-thiophen-2-ylmethyl-6,7,8,9-...)
Affinity DataEC50:  67nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120812(8-Benzyl-2-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-5...)
Affinity DataEC50:  143nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120788(8-Butyl-2-(2-fluoro-phenyl)-6,7,8,9-tetrahydro-5H-...)
Affinity DataEC50:  247nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120808(2-(2-Fluoro-phenyl)-8-(4-methyl-benzoyl)-6,7,8,9-t...)
Affinity DataEC50:  327nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120786(8-Benzyl-2-(3-methoxy-phenyl)-6,7,8,9-tetrahydro-5...)
Affinity DataEC50:  268nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120773(8-(2-Fluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8,9-t...)
Affinity DataEC50:  256nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120798(2-(2-Fluoro-phenyl)-8-(3H-imidazol-4-ylmethyl)-6,7...)
Affinity DataEC50:  459nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120783(8-Benzyl-2-(2-fluoro-phenyl)-6,7,8,9-tetrahydro-5H...)
Affinity DataEC50:  20nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120795(2-(2-Fluoro-phenyl)-8-(2-methyl-benzoyl)-6,7,8,9-t...)
Affinity DataEC50:  134nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120793(8-Cyclopropylmethyl-2-(2-fluoro-phenyl)-6,7,8,9-te...)
Affinity DataEC50:  1.16E+3nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120791(8-Cyclohexylmethyl-2-(2-fluoro-phenyl)-6,7,8,9-tet...)
Affinity DataEC50:  202nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120809(8-Benzyl-2-phenyl-6,7,8,9-tetrahydro-5H-1,3a,5,8-t...)
Affinity DataEC50:  184nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120776(8-Benzyl-2-(2,4-difluoro-phenyl)-6,7,8,9-tetrahydr...)
Affinity DataEC50:  210nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273002(5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochlor...)
Affinity DataEC50:  1.82E+5nMAssay Description:Agonist activity at rat recombinant GABAA alpha-2-beta-3-gamma-2 receptor expressed in HEK293 cells assessed as normalization of GABA-induced current...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50060088(2-(6-Chloro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-N...)
Affinity DataEC50:  1.30E+9nMAssay Description:Potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alpha-2-beta-2-gamma-2 subunitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
LigandPNGBDBM26266(Ambien | CHEMBL911 | ZPM | N,N-dimethyl-2-[6-methy...)
Affinity DataEC50:  1.80E+9nMAssay Description:Potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alpha-2-beta-2-gamma-2 subunitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50060124(2-[6-Chloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyri...)
Affinity DataEC50:  6.60E+9nMAssay Description:Potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alpha-2-beta-2-gamma-2 subunitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50164557(2-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-imi...)
Affinity DataEC50:  600nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50164559(1-Phenyl-2-p-tolyl-1H-imidazole-4-carboxylic acid ...)
Affinity DataEC50:  4.10E+3nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50164560(2-(4-Chloro-phenyl)-1-phenyl-1H-imidazole-4-carbox...)
Affinity DataEC50:  4.20E+3nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50125935(CHEMBL681 | R(+)-etomidate | Amidate | (R)-1-(1-ph...)
Affinity DataEC50:  3.50E+3nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50055935(5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-...)
Affinity DataEC50:  5.00E+4nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50164561(1,2-Bis-(4-fluoro-phenyl)-1H-imidazole-4-carboxyli...)
Affinity DataEC50:  3.10E+3nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50164562([2-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-im...)
Affinity DataEC50:  1.30E+3nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50164558(1,2-Bis-(4-chloro-phenyl)-1H-imidazole-4-carboxyli...)
Affinity DataEC50:  1.50E+3nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50164563(2-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-imi...)
Affinity DataEC50:  4.40E+3nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50164564(2-(4-Amino-phenyl)-1-(2,4-dichloro-phenyl)-1H-imid...)
Affinity DataEC50:  4.30E+3nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50164565(1,2-Diphenyl-1H-imidazole-4-carboxylic acid ethyl ...)
Affinity DataEC50:  6.40E+3nMAssay Description:Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
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