Compile Data Set for Download or QSAR
Report error Found 299 Enz. Inhib. hit(s) with Target = 'Histone acetyltransferase KAT6B'
LigandPNGBDBM662989(Synthesis of N-(5-((1H-pyrazol-1-yl)methyl)-3,4-di...)
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM662985(Synthesis of 7-chloro-1-(2-chlorophenyl)-4-(prop-2...)
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM662990(Synthesis of N-(5-((1H-pyrazol-1-yl)methyl)-3,4-di...)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM739492(N-(4-((1H-pyrazol-1-yl)methyl)-2,2-difluoro-[1,3]d...)
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757557(6-(Dimethylamino)-N-((2-methylquinolin-8-yl)sulfon...)
Affinity DataIC50: 1.78nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757472(US12357603, Example 110)
Affinity DataIC50: 3.82nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM534100(WO2022081807, Example 207)
Affinity DataIC50: 5.65nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

LigandPNGBDBM534020(WO2022081807, Example 127 | 6-(Azetidin-1-yl)-N-(5...)
Affinity DataIC50: 5.67nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757475(US12357603, Example 113)
Affinity DataIC50: 7.24nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757532(6-(Dimethylamino)-N-(2-ethoxy-5-sec-butyl-phenyl)s...)
Affinity DataIC50: 8.84nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM534117(WO2022081807, Example 224)
Affinity DataIC50: 9.82nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

LigandPNGBDBM534118(WO2022081807, Example 225 | 6-(Azetidin-1-yl)-N-[(...)
Affinity DataIC50: 9.82nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757321(US12357603, Example 13)
Affinity DataIC50: 11.6nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757543(N-[(5-(tert-butyl)-2-cyclobutoxyphenyl)sulfonyl]-6...)
Affinity DataIC50: 11.9nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM534006(WO2022081807, Example 113 | N-(5-tert-butyl-2-etho...)
Affinity DataIC50: 12nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757554(N-([1,1'-biphenyl]-2-ylsulfonyl)-6-(dimethylamino)...)
Affinity DataIC50: 12.8nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM534121(WO2022081807, Example 228)
Affinity DataIC50: 13nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757546(N-((5-(tert-butyl)-2-methoxyphenyl)sulfonyl)-6-(di...)
Affinity DataIC50: 13.9nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM533972(WO2022081807, Example 79 | 6-(Azetidin-1-yl)-4-flu...)
Affinity DataIC50: 14nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757556(6-(Dimethylamino)-N-((2-ethoxyphenyl)sulfonyl)-4-(...)
Affinity DataIC50: 14.7nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM534021(WO2022081807, Example 128)
Affinity DataIC50: 15nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

LigandPNGBDBM534106(WO2022081807, Example 213)
Affinity DataIC50: 15nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757491(US12357603, Example 129)
Affinity DataIC50: 16.8nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757474(US12357603, Example 112)
Affinity DataIC50: 18.1nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757318(US12357603, Example 12)
Affinity DataIC50: 18.2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM534149(WO2022081842, Example 24)
Affinity DataIC50: 19nMAssay Description: Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757473(US12357603, Example 111)
Affinity DataIC50: 19nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757540(N-[(2-(Benzyloxy)-5-(tert-butyl)phenyl)sulfonyl]-6...)
Affinity DataIC50: 19.4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM534023(WO2022081807, Example 130)
Affinity DataIC50: 20nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

LigandPNGBDBM534045(WO2022081807, Example 152)
Affinity DataIC50: 20nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

LigandPNGBDBM534088(WO2022081807, Example 195)
Affinity DataIC50: 20nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

LigandPNGBDBM534107(WO2022081807, Example 214 | 6-(azetidin-1-yl)-N-[2...)
Affinity DataIC50: 20nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

LigandPNGBDBM533866(WO2022081807, Example 1 | 6-(Azetidin-1 -yl)-N-(2-...)
Affinity DataIC50: 21nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757541(N-((5-(tert-butyl)-2-(cyclopropylmethoxy)phenyl)su...)
Affinity DataIC50: 21.3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM534024(WO2022081807, Example 131 | 6-(Azetidin-1-yl)-N-[2...)
Affinity DataIC50: 23nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

LigandPNGBDBM534146(WO2022081842, Example 22 | 6-Cyclopropyl-4-fluoro-...)
Affinity DataIC50: 23nMAssay Description: Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757488(US12357603, Example 126)
Affinity DataIC50: 23.8nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM730788(US20250122182, Example 45, WO2020/254946)
Affinity DataIC50: 24nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details

TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757538(N-[2-(cyclopropylmethoxy)-5-isopropyl-phenyl]sulfo...)
Affinity DataIC50: 24nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM663033(Synthesis of N-(6-((1H-pyrazol-1-yl)methyl)-4-(flu...)
Affinity DataIC50: 25.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2025
Entry Details

TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757586(US12357603, Example 225)
Affinity DataIC50: 25.8nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757496(US12357603, Example 134)
Affinity DataIC50: 25.9nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757547(N-((2-((2,2-difluorocyclopropyl)methoxy)-5-isoprop...)
Affinity DataIC50: 26.1nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757331(US12357603, Example 21)
Affinity DataIC50: 26.7nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM534122(WO2022081807, Example 229 | 6-(Azetidin-1-yl)-N-[(...)
Affinity DataIC50: 28nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

LigandPNGBDBM534150(WO2022081842, Example 25 | 6-Cyclopropyl-N-(2-etho...)
Affinity DataIC50: 28nMAssay Description: Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081842

LigandPNGBDBM50518832(CHEMBL4455897 | US10829446, Compound 36)
Affinity DataIC50: 28nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KAT6B (431 to end residues) expressed in baculovirus infected Sf9 insect cells using acetyl coe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50518832(CHEMBL4455897 | US10829446, Compound 36)
Affinity DataIC50: 28nMAssay Description:Inhibition of KAT6B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM534124(WO2022081807, Example 231 | 6-(Azetidin-1-yl)-N-((...)
Affinity DataIC50: 29nMAssay Description:Kat6b inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022081807

TargetHistone acetyltransferase KAT6B [431-2073](Homo sapiens (Human))TBA
LigandPNGBDBM757427(US12357603, Example 65)
Affinity DataIC50: 34.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
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