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Report error Found 110 Enz. Inhib. hit(s) with Target = 'Homeodomain-interacting protein kinase 4'
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  0.510nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  2.70nMAssay Description:Binding affinity to HIPK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  3.30nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 3.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  3.90nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50532781(CHEMBL4571241)
Affinity DataKd:  11nMAssay Description:Binding affinity to human HIPk4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50532781(CHEMBL4571241)
Affinity DataKd:  11nMAssay Description:Binding affinity to human HIPk4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50172243(CHEMBL3103192)
Affinity DataIC50: 40nMAssay Description:Inhibition of Hipk4 (unknown origin) by quantitative PCRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  46nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM26300(cid_16007391 | 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)a...)
Affinity DataKd:  97nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50242737((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50563891(CHEMBL4793380)
Affinity DataIC50: 127nMAssay Description:Inhibition of human HIPK4 using RRRFRPASPLRGPPK as substrate after 40 mins by [gamma-33ATP] radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataKd:  130nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 138nMAssay Description:Inhibition of human HIPK4 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  150nMAssay Description:Binding affinity to HIPK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  150nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  160nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  160nMAssay Description:Binding affinity to HIPK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50506351(CHEMBL4439133)
Affinity DataIC50: 176nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged HIPK4 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd:  220nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50559221(CHEMBL4763392)
Affinity DataKd:  290nMAssay Description:Binding affinity to human HIPK4 by KINOMEscan scanMAX assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd:  310nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 314nMAssay Description:Inhibition of human HIPK4 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd:  320nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd:  320nMAssay Description:Binding affinity to HIPK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  350nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataKd:  360nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  390nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataKd:  400nMAssay Description:Binding affinity to HIPK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  424nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-tagged HIPK4 (unknown origin) expressed in baculovirus infected Sf9 insect cells incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  472nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-tagged HIPK4 (unknown origin) expressed in baculovirus infected Sf9 insect cells incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50526803(CHEMBL4434871 | US10870651, Compound 101)
Affinity DataIC50: 550nMAssay Description:Compounds of the invention were assayed for activity against a variety of different kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM31088(1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...)
Affinity DataKd:  560nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50627464(CHEMBL5426285)
Affinity DataIC50: 620nMAssay Description:Inhibition of human HIPK4 assessed as remaining activity by eurofins-cerep kinase profiler analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM311261(US10155760, Example 117 | (S)-methyl (5-((2-amino-...)
Affinity DataIC50: 650nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM15138(Biochemistry 469551 Compound 11 | 5-indazolyl pyri...)
Affinity DataKd:  760nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  950nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  950nMAssay Description:Binding affinity to HIPK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  960nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataKd:  960nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  970nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM174948(US9096593, P-2049)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  1.00E+3nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM311210(US10155760, Example 66 | (S)-methyl (5-((2-amino-2...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of HIPK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding constant for HIPK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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