Compile Data Set for Download or QSAR
Report error Found 277 Enz. Inhib. hit(s) with Target = 'Insulin-degrading enzyme'
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459189(CHEMBL4211248)
Affinity DataKd:  22nMAssay Description:Binding affinity to IDE E111Q mutant (unknown origin) using N-terminal FITC-labeled compound after 2 hrs in absence of light at 298 K by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602605(CHEMBL5195657)
Affinity DataEC50:  5.50E+3nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602605(CHEMBL5195657)
Affinity DataEC50:  5.01E+3nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602606(CHEMBL5201963)
Affinity DataEC50:  1.00E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602606(CHEMBL5201963)
Affinity DataEC50:  1.00E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602607(CHEMBL5208860)
Affinity DataEC50:  2.14E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602608(CHEMBL5191945)
Affinity DataEC50:  2.69E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602609(CHEMBL5179418)
Affinity DataEC50:  1.32E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602610(CHEMBL5198743)
Affinity DataEC50:  7.94E+3nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602611(CHEMBL5186397)
Affinity DataEC50:  1.02E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602612(CHEMBL5189585)
Affinity DataEC50:  6.76E+3nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602613(CHEMBL5170331)
Affinity DataEC50:  1.38E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602614(CHEMBL5204153)
Affinity DataEC50:  2.88E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602615(CHEMBL5185924)
Affinity DataEC50:  2.69E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602616(CHEMBL5202559)
Affinity DataEC50:  1.55E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602617(CHEMBL5185555)
Affinity DataEC50:  7.24E+3nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602618(CHEMBL5198912)
Affinity DataEC50:  8.13E+3nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602619(CHEMBL5193447)
Affinity DataEC50:  1.41E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602620(CHEMBL5169861)
Affinity DataEC50:  1.02E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602621(CHEMBL5204606)
Affinity DataEC50:  1.45E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602622(CHEMBL5184269)
Affinity DataEC50:  3.89E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602623(CHEMBL5203883)
Affinity DataEC50:  8.13E+3nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50602624(CHEMBL5194929)
Affinity DataEC50:  1.23E+4nMAssay Description:Activation of human recombinant IDE using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-trp as substrate incubated for 10 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataEC50:  530nMAssay Description:Induction of human recombinant IDE-mediated insulin hydrolysis preincubated for 10 mins measured after 30 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50525490(CHEMBL4437643)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant IDE exosite (unknown origin) expressed in Escherichia coli using insulin as substrate incubated for 4 hrs by AlphaLisa assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459189(CHEMBL4211248)
Affinity DataIC50: 22nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using ATTO 655- Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459187(CHEMBL4211765)
Affinity DataIC50: 44nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50525489(CHEMBL4556893)
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal His6-tagged mouse recombinant IDE Escherichia coli BL21 (DE3) cells using fluorogenic peptide Mca-RPPGFSAFK(Dnp)-OH as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50525489(CHEMBL4556893)
Affinity DataIC50: 50nMAssay Description:Inhibition of IDE (unknown origin) assessed as cleavage of Mca-RPPGFSAFK(Dnp)-OH by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50525489(CHEMBL4556893)
Affinity DataIC50: 50nMAssay Description:Inhibition of IDE (unknown origin) assessed as cleavage of Mca-RPPGFSAFK(Dnp)-OH by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM209049(US9243038, 26)
Affinity DataIC50: 54nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 56nMAssay Description:Inhibition of human IDE using insulin as substrate preincubated for 10 mis followed by substrate addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50514415(CHEMBL4527561)
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant IDE pre-incubated for 10 mins before Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp substrate addition and measured after 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM314096(US9610322, 6b (trans olefin))
Affinity DataIC50: 60nMAssay Description:In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM209051(US9243038, 27)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM209032(US9243038, 6b (trans olefin) | US9243038, 6a (cis ...)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM209053(US9243038, 8)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM209054(US9243038, 13)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM209041(US9243038, 15)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459188(CHEMBL4206878)
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 60nMAssay Description:Inhibition of wild type human IDE catalytic site using insulin as substrate preincubated for 10 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM209045(US9243038, 20)
Affinity DataIC50: 65nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459190(CHEMBL4208119)
Affinity DataIC50: 74nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459181(CHEMBL4207403)
Affinity DataIC50: 77nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM209048(US9243038, 28)
Affinity DataIC50: 80nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM209046(US9243038, 21)
Affinity DataIC50: 85nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459180(CHEMBL4203249)
Affinity DataIC50: 86nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
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