Compile Data Set for Download or QSAR
Report error Found 7550 Enz. Inhib. hit(s) with Target = 'Integrase'
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50065796(2-[2-(3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quino...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of Human immunodeficiency virus 1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM71542(Primaquine bisphosphate | N4-(6-methoxy-8-quinolin...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Human immunodeficiency virus 1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataEC50:  0.210nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity incubated for 10 mins by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM22985(Aralen | Chlorochin | CHLOROQUINE PHOSPHATE | Chlo...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of Human immunodeficiency virus 1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50629934(CHEMBL5439129)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of HIV-1 integrase expressed in HEK293T co-transfected with CS-II Luci vector incubated for 48 hrs by Bright-Glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50062551(Dolutegravir | GSK1349572 | CHEBI:76010 | S-349572)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of HIV integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50021581(CHEMBL414850 | L-870810)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of HIV1 integrase using labelled oligonucleotide substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM23402(5-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(4-fluoropheny...)
Affinity DataIC50: 0.5nMAssay Description:In vitro concentration required to inhibit the overall HIV-1 integrase strand transferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50021581(CHEMBL414850 | L-870810)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of HIV1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50170870(CHEMBL3805182)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of pseudotype HIV1 integrase strand transfer activity assessed as reduction in viral replication in HIV1 infected human CIP4 cells after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2017
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50062551(Dolutegravir | GSK1349572 | CHEBI:76010 | S-349572)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of HIV-1 integrase Q148K mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50170867(CHEMBL3806067)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of pseudotype HIV1 integrase strand transfer activity assessed as reduction in viral replication in HIV1 infected human CIP4 cells after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2017
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50287594(Asunaprevir | BMS 650032 | BMS-650032)
In Depth
Date in BDB:
TBA
Entry Details
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50273913(CHEMBL4127663)
Affinity DataEC50:  1nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataEC50:  1nMAssay Description:Inhibition of HIV-1 integrase mutant strand transfer activity incubated for 10 mins by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50170867(CHEMBL3806067)
Affinity DataIC50: 1nMAssay Description:Inhibition of pseudotype HIV1 integrase strand transfer activity assessed as reduction in viral replication in in HIV1 infected human CIP4 cells afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2017
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50484379(CHEMBL1917873)
Affinity DataIC50: 1nMAssay Description:Inhibition of HIV1 integrase strand transfer by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50273950(CHEMBL4128240)
Affinity DataEC50:  1nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50647541(CHEMBL5597897)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50062551(Dolutegravir | GSK1349572 | CHEBI:76010 | S-349572)
Affinity DataEC50:  1.5nMAssay Description:Inhibition of wild type HIV-1 NL4-3 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50062551(Dolutegravir | GSK1349572 | CHEBI:76010 | S-349572)
Affinity DataEC50:  1.5nMAssay Description:Inhibition of HIV-1 NL4-3 integrase T97A/Y143C double mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50647539(CHEMBL5597978)
Affinity DataIC50: 1.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HIV1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50170591(CHEMBL2403116)
Affinity DataIC50: 2nMAssay Description:Inhibition of pseudotype HIV1 integrase strand transfer activity assessed as reduction in viral replication in HIV1 infected human CIP4 cells after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2017
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294658(US10112899, Example 137)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294659(US10112899, Example 138)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294661(US10112899, Example 140)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50273951(CHEMBL4126165)
Affinity DataIC50: 2nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50480704(CHEMBL556894)
Affinity DataIC50: 2nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity treated after enzyme assembly and washingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50480698(CHEMBL549422)
Affinity DataIC50: 2nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity treated after enzyme assembly and washingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294851(US10112899, Example 321)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294719(US10112899, Example 196)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294657((S)-2-(tert-butoxy)-2-((R)-2-(5-fluoro-2-methylben...)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50489299(CHEMBL2316125)
Affinity DataIC50: 2nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50273952(CHEMBL4130102)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50273964(CHEMBL4130252)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294814(US10112899, Example 285)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294679(US10112899, Example 158)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50273965(CHEMBL4127923)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM50647538(CHEMBL5597609)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294680(US10112899, Example 159)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294666(US10112899, Example 145)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50273915(CHEMBL4127891)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50170870(CHEMBL3805182)
Affinity DataIC50: 2nMAssay Description:Inhibition of pseudotype HIV1 integrase strand transfer activity assessed as reduction in viral replication in in HIV1 infected human CIP4 cells afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2017
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294738(US10112899, Example 212 | (S)-2-(tert-butoxy)-2-((...)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50273916(CHEMBL4126289)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294670(US10112899, Example 149)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetIntegrase(Human immunodeficiency virus type 1)TBA
LigandPNGBDBM50273948(CHEMBL4127873)
Affinity DataEC50:  2nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity assessed as reduction in viral replication in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294673(US10112899, Example 152)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetIntegrase(Human immunodeficiency virus type 1)
Maharishi Markandeshwar (Deemed To Be University)

Curated by ChEMBL
LigandPNGBDBM294691(US10112899, Example 169)
Affinity DataIC50: 2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

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