Compile Data Set for Download or QSAR
Report error Found 1610 Enz. Inhib. hit(s) with Target = 'Integrin alpha-V/beta-6'
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataEC50:  0.158nMAssay Description:Induction of integrin alphaVbeta6 receptor internalization in human primary human lung epithelial cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKd:  0.0160nMAssay Description:Binding affinity to human integrin alphaVbeta6 after 24 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKd:  0.0158nMAssay Description:Binding affinity to human integrin alphaVbeta6 after 24 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50021393(CHEMBL3289604)
Affinity DataEC50:  167nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50021394(CHEMBL3289605)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50021395(CHEMBL3289606)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50550222(CHEMBL4777693)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50550223(CHEMBL4794300)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50550226(CHEMBL4782288)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50550224(CHEMBL4797755)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50505779(CHEMBL4461771)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50550227(CHEMBL4755971)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50505781(CHEMBL4461668)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50550228(CHEMBL4743438)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50505772(CHEMBL4589062)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50505782(CHEMBL4586928)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50439683(CHEMBL2418221)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50222360(Ac-Asp-Arg-Leu-Asp-Ser-OH | CHEMBL238484)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaVbeta6 in human HT-29 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50110227(CHEMBL267434 | CHEMBL2332368 | 3-{2-[4-(4-Methyl-p...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of integrin alphavbeta6 (unknown origin) by Merck binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50110227(CHEMBL267434 | CHEMBL2332368 | 3-{2-[4-(4-Methyl-p...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50110228(3-{2-[4-(4-Methyl-pyridin-2-ylamino)-butyrylamino]...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279573((3S)-3-(3,5-dibromophenyl)-3-[[2-[[5-[(5-hydroxy-1...)
Affinity DataIC50: 0.200nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50530099(CHEMBL4441624)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta6 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50530099(CHEMBL4441624)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta6 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50565948(CHEMBL4780301)
Affinity DataIC50: 0.260nMAssay Description:Binding affinity to human integrin alphaVbeta6 incubated for 1 hr by ELISA based solid phase integrin binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279561((3S)-3-(3-bromo-5-(trifluoromethyl)phenyl)-3-(2-(3...)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279566((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl]3-[[2-[...)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279568((3S)-3-[3-bromo-5-(trifluoromethyl)phenyl]-3-[[2-[...)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279569((3S)-3-[3,5-bis(trifluoromethyl)phenyl)-3-(2-(3-hy...)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279560((3S)-3-(3,5-dibromophenyl)-3-(2-(3-hydroxy-5-((5-h...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279562((3S)-3-[3-chloro-5-(difluoromethyl)phenyl)-3-(2-(3...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279563((3S)-3-[3-bromo-5-(difluoromethyl)phenyl)-3-(2-(3-...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279565((3S)-3-[3-bromo-5-chloro-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279567((3S)-3-(3-bromo-5-chloro-phenyl)-3-[[2-[[5-[(5-hyd...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279572((3S)-3-[3-bromo-5-fluoro-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50110236(3-(3,5-Dichloro-phenyl)-3-{2-[5-(4-methyl-pyridin-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279564((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl)-3-(2-(...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279570((3S)-3-[3-bromo-5-methyl-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279575((3S)-3-[3-chloro-5-(trifluoromethoxy)phenyl)-3-(2-...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM606867(US11685738, Compound A3)
Affinity DataIC50: 0.570nMAssay Description:The full reaction (Integrin-Ligand Interaction) was optimized as above. Integrin coupled beads were taken for the experiment. 2 μL of 10 nM/20 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279571((3S)-3-[3-chloro-5-methyl-phenyl)-3-(2-(3-hydroxy-...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279574((3S)-3-[3,5-dichloro-phenyl)-3-(2-(3-hydroxy-5-((5...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50110232(3-Biphenyl-4-yl-3-{2-[5-(pyridin-2-ylamino)-pentan...)
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at alphavbeta6 integrin receptor (unknown origin) by cell-free ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50110232(3-Biphenyl-4-yl-3-{2-[5-(pyridin-2-ylamino)-pentan...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50530110(CHEMBL4575627)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta6 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50530110(CHEMBL4575627)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta6 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM279576((3S)-3-(3-bromo-5-(trifluoromethoxy)phenyl)-3-(2-(...)
Affinity DataIC50: 0.700nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP (R&D Systems, 246-LP) diluted to 0.25 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human integrin alphaVbeta6 in lung tissue slices derived from IPF patient assessed as reduction in SMAD2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50464106(CHEMBL4237498)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human integrin alphaVbeta6 expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP after 30 mins by BC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50209461((3S)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at alphavbeta6 integrin receptor in human HT29 cells after 4 hrs using p-nitrophenyl phosphate by colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
Displayed 1 to 50 (of 1610 total ) | Next | Last >>
Jump to: