Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with Target = 'Interleukin-1 receptor type 1'
TargetInterleukin-1 receptor type 1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50408850(CHEMBL1626304 | DNDI1417291)
Affinity DataKd:  0.316nMAssay Description:Inhibition of human IL1-R1 assessed as dissociation constant incubated for 5 mins by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetInterleukin-1 receptor type 1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50457655(CHEMBL4213787)
Affinity DataIC50: 720nMAssay Description:Inhibition of IL1R in TLR null HEK-blue cells assessed as decrease in IL-1beta-stimulated NF-kappaB activation-mediated SEAP production after 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInterleukin-1 receptor type 1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50543142(CHEMBL4641633)
Affinity DataIC50: 6.50E+3nMAssay Description:Antagonist activity at IL1R in human PBMC assessed as inhibition of IL1beta-induced TNFalpha production preincubated for 30 mins followed by IL1beta ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor type 1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50516677(CHEMBL4514780)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IL1R in human monocytes assessed as reduction in IL1beta-induced TNFalpha productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed