Compile Data Set for Download or QSAR
Report error Found 1421 Enz. Inhib. hit(s) with Target = 'Kinesin-like protein KIF18A'
TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM50404037(CHEMBL5287302)
Affinity DataKd: >5.00E+4nMAssay Description:Binding affinity to KIF18A (unknown origin) by NMR based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM762883(N-(4-(5-(2-(3,3-Difluoropiperidin-1-yl)-6-methylpy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762886(2-Hydroxy-N-(4-(5-(6-methyl-2-(3,3,3-trifluoroprop...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762888(N-(4-(5-(2-(4,4-Difluoropiperidin-1-yl)-6-methylpy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762896(N-(4-(5-(2-(6,6-Difluoro-3-azabicyclo[3.1.0]hexan-...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM636917(US20230382889, Compound 59 | N-(5-(4-(6-(4,4-diflu...)
Affinity DataIC50: 1.60nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM762880(N-(4-(5-(2-(4,4-Difluoropiperidin-1-yl)-6-methylpy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762884(N-(4-(5-(2-(4-fluoropiperidin-1-yl)-6-methylpyrimi...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762890(N-(4-(5-(2-(4,4-Difluoropiperidin-1-yl)-6-methylpy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762897(N-(4-(4-(2-(4,4-Difluoropiperidin-1-yl)-6-ethylpyr...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762906(N-(4-(5-(2-(4-Fluoropiperidin-1-yl)-6-methylpyridi...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762910(N-(4-(4-(2-(4,4-Difluorocyclohexyl)-6-methylpyrimi...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762912(US20250250264, Compound I-112)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762918(N-(4-(4-(2-(3,3-Difluoropiperidin-1-yl)-6-methylpy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM636907(US20230382889, Compound 51 | US20230382889, Compou...)
Affinity DataIC50: 2.40nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM636907(US20230382889, Compound 51 | US20230382889, Compou...)
Affinity DataIC50: 2.80nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM637003(US20230382889, Compound 144 | N-(4-(4-(6-(4,4-difl...)
Affinity DataIC50: 2.80nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM695769(US12084420, Compound 368b | US12084420, Compound 3...)
Affinity DataIC50: 3nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

LigandPNGBDBM762894(N-(4-(5-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-6-methy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762899(N-(4-(5-(6-Methyl-2-(3,3,3-trifluoropropoxy)pyrimi...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762919(N-(4-(4-(1-(3,3-Difluorocyclobutyl)-6-oxo-1,6-dihy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM636907(US20230382889, Compound 51 | US20230382889, Compou...)
Affinity DataIC50: 3.10nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM695755(US12084420, Compound 352b)
Affinity DataIC50: 3.30nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM636921(US20230382889, Compound 63 | N-(4-(4-(6-(4,4-diflu...)
Affinity DataIC50: 3.40nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM695769(US12084420, Compound 368b | US12084420, Compound 3...)
Affinity DataIC50: 3.5nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM637019(US20230382889, Compound 158 | 2-(4,4-difluoropiper...)
Affinity DataIC50: 3.80nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM695767(US12084420, Compound 367b | US12084420, Compound 3...)
Affinity DataIC50: 3.90nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM695754(US12084420, Compound 352a)
Affinity DataIC50: 4nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

LigandPNGBDBM636903(US20230382889, Compound 47 | N-(4-(4-(2-(4,4-diflu...)
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762895(N-(4-(5-(6-(4,4-Difluoropiperidin-1-yl)-4-methylpy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762903(N-(4-(5-(2-(3-Fluoropiperidin-1-yl)-6-methylpyrimi...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM636954(US20230382889, Compound 96 | N-(4-(1-(6-(4,4-diflu...)
Affinity DataIC50: 4.40nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM637005(US20230382889, Compound 146 | 3-(4,4-difluoropiper...)
Affinity DataIC50: 4.40nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM637021(US20230382889, Compound 160 | N-(4-(4-(2-(4,4-difl...)
Affinity DataIC50: 4.40nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM636981(US20230382889, Compound 123 | N-(4-(4-(5- (cyclope...)
Affinity DataIC50: 4.60nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM695644(US12084420, Compound 228 | N-(1$#8243;-(3-((2-azas...)
Affinity DataIC50: 4.60nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM636890(US20230382889, Compound 25 | N-(4-(4-(5- (cyclopen...)
Affinity DataIC50: 4.70nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM695622(US12084420, Compound 190 | N-(3-methylenecyclobuty...)
Affinity DataIC50: 4.80nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM695767(US12084420, Compound 367b | US12084420, Compound 3...)
Affinity DataIC50: 4.80nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM636941(US20230382889, Compound 84 | N-(4-(4-(1-(4,4-diflu...)
Affinity DataIC50: 5nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM695753(US12084420, Compound 352 | N-(1$#8243;-(5- (cyclop...)
Affinity DataIC50: 5nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

LigandPNGBDBM762909(N-(4-(4-(2-(4,4-Difluoropiperidin-1-yl)pyrimidin-4...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762911(US20250250264, Compound I-111)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762915(N-(4-(4-(6-Methyl-2-(3,3,3-trifluoropropoxy)pyrimi...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM762921(N-(4-(4-(2-(4,4-Difluoropiperidin-1-yl)-6-methylpy...)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM636874(US20230382889, Compound 8 | N-(4-(5-(6-(4,4-difluo...)
Affinity DataIC50: 5.10nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM695765(US12084420, Compound 364 | N-(1$#8243;-(4- (cyclop...)
Affinity DataIC50: 5.10nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM636947(US20230382889, Compound 90a | US20230382889, Compo...)
Affinity DataIC50: 5.20nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM695705(US12084420, Compound 311 | N-(bicyclo[1.1.1]pentan...)
Affinity DataIC50: 5.20nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Amgen Research

Curated by ChEMBL
LigandPNGBDBM637002(US20230382889, Compound 143 | N-(4-(4-(6-(4,4-difl...)
Affinity DataIC50: 5.5nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

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