Compile Data Set for Download or QSAR
Report error Found 927 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 3'
TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154708(US8999957, Table 2, Compound 45)
Affinity DataKd:  0.0100nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154710(US8999957, Table 2, Compound 47)
Affinity DataKd:  0.0200nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154709(US8999957, Table 2, Compound 46)
Affinity DataKd:  0.0300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154670(US8999957, Table 2, Compound 7)
Affinity DataKd:  0.0520nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154713(US8999957, Table 2, Compound 50)
Affinity DataKd:  0.100nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154698(US8999957, Table 2, Compound 35)
Affinity DataKd:  0.100nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154699(US8999957, Table 2, Compound 36)
Affinity DataKd:  0.100nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 0.130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154694(US8999957, Table 2, Compound 31)
Affinity DataKd:  0.130nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154680(US8999957, Table 2, Compound 17)
Affinity DataKd:  0.150nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154692(US8999957, Table 2, Compound 29)
Affinity DataKd:  0.200nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154681(US8999957, Table 2, Compound 18)
Affinity DataKd:  0.210nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154696(US8999957, Table 2, Compound 33)
Affinity DataKd:  0.210nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154673(US8999957, Table 2, Compound 10)
Affinity DataKd:  0.220nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154687(US8999957, Table 2, Compound 24)
Affinity DataKd:  0.240nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154720(US8999957, Table 2, Compound 59)
Affinity DataKd:  0.260nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154682(US8999957, Table 2, Compound 19)
Affinity DataKd:  0.270nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154706(US8999957, Table 2, Compound 43)
Affinity DataKd:  0.280nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154599(US8999957, Column 153, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154634(US8999957, Table 1, Compound 2)
Affinity DataKd:  0.300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094465(CHEMBL3590106 | US10525036, Example BVD-523 | US10...)
Affinity DataKi: <0.300nMAssay Description:Binding affinity to ERK1 (unknown origin) measured after 20 mins in presence of [gamma33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154599(US8999957, Column 153, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.300nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154711(US8999957, Table 2, Compound 48)
Affinity DataKd:  0.390nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154665(US8999957, Table 2, Compound 2)
Affinity DataKd:  0.400nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
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TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154666(US8999957, Table 2, Compound 3)
Affinity DataKd:  0.400nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154712(US8999957, Table 2, Compound 49)
Affinity DataKd:  0.420nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154675(US8999957, Table 2, Compound 12)
Affinity DataKd:  0.480nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154667(US8999957, Table 2, Compound 4)
Affinity DataKd:  0.5nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154674(US8999957, Table 2, Compound 11)
Affinity DataKd:  0.510nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154669(US8999957, Table 2, Compound 6)
Affinity DataKd:  0.520nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154691(US8999957, Table 2, Compound 28)
Affinity DataKd:  0.530nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  0.550nMAssay Description:Inhibition of ERK1 phosphorylation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.580nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.580nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
Affinity DataKd:  0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154600(US8999957, Column 153, Compound 5 | US8999957, Tab...)
Affinity DataKd:  0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154635(US8999957, Table 1, Compound 3)
Affinity DataKd:  0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154700(US8999957, Table 2, Compound 37)
Affinity DataKd:  0.600nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154591(US8999957, Column 141, Compound 7 | US8999957, Tab...)
Affinity DataKd:  0.610nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154591(US8999957, Column 141, Compound 7 | US8999957, Tab...)
Affinity DataKd:  0.610nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50601918(TEMUTERKIB | Temuterkib | Ly 3214996 | Ly3214996 |...)
Affinity DataKi:  0.650nMAssay Description:Binding affinity to ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154676(US8999957, Table 2, Compound 13)
Affinity DataKd:  0.660nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154596(US8999957, Column 152, Compound 1)
Affinity DataKd:  0.800nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154664(US8999957, Table 2, Compound 1)
Affinity DataKd:  0.810nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154688(US8999957, Table 2, Compound 25)
Affinity DataKd:  0.830nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154685(US8999957, Table 2, Compound 22)
Affinity DataKd:  0.900nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154719(US8999957, Table 2, Compound 57)
Affinity DataKd:  0.970nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM120095(US8697715, 39 | US9259470, 39 | US10525036, Exampl...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 3(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154589(US8999957, Column 141, Compound 5 | US8999957, Tab...)
Affinity DataKd:  1.20nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2015
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM696313(US20240300975, Compound WX001)
Affinity DataIC50: 1.20nMAssay Description:1. Purpose of the Assay:The ability of compounds to inhibit ERK1 and ERK2 kinase activity was measured.2. Assay Buffer:20 mM Hepes (pH 7.5), 10 mM Mg...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
Go to US Patent

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