Compile Data Set for Download or QSAR
Report error Found 8138 Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit'
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50521626BDBM50521626(CHEMBL4448433)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human c-KIT A loop exon 17 D820Y single mutant using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit [V654A](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 792593BDBM792593(US20260042753, Compound A232)
Affinity DataIC50: 0.0900nMAssay Description:CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 690297BDBM690297((S)-5-(3-cyclopropyl-1-(2-hydroxy-3-methoxypropyl)...)
Affinity DataIC50: 0.100nMAssay Description:For the PathScan phospho c-kit (Tyr719) sandwich ELISA: M-07e cells were resuspended at 2×106 cells/mL in phenol red free, serum-free, GM-CSF-free Is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 690329BDBM690329((S)-N-(2-chloro-5-(2-cyclopropyl-2H-tetrazol-5-yl)...)
Affinity DataIC50: 0.100nMAssay Description:For the PathScan phospho c-kit (Tyr719) sandwich ELISA: M-07e cells were resuspended at 2×106 cells/mL in phenol red free, serum-free, GM-CSF-free Is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50521626BDBM50521626(CHEMBL4448433)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human c-KIT A loop exon 17 Y823D single mutant using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 139540BDBM139540(US8889696, Staurosporine | US9051313, Staurosporin...)
Affinity DataIC50: 0.180nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2015
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50521626BDBM50521626(CHEMBL4448433)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human c-KIT A loop exon 11/17 V560G/N822K double mutant using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 690317BDBM690317((S)-N-(2-chloro-5-(2-cyclopropyl-2H-tetrazol-5-yl)...)
Affinity DataIC50: 0.200nMAssay Description:For the PathScan phospho c-kit (Tyr719) sandwich ELISA: M-07e cells were resuspended at 2×106 cells/mL in phenol red free, serum-free, GM-CSF-free Is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 690295BDBM690295(5-(3-cyclopropyl-1-(2-hydroxy-2-methylpropyl)-1H-p...)
Affinity DataIC50: 0.200nMAssay Description:For the PathScan phospho c-kit (Tyr719) sandwich ELISA: M-07e cells were resuspended at 2×106 cells/mL in phenol red free, serum-free, GM-CSF-free Is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of His-tagged KIT D816H mutant (unknown origin) extracted from Escherichia coli BL21 (DE3) by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 690336BDBM690336(US20240262826, Compound 284 | (S)-N-(2-chloro-5-(2...)
Affinity DataIC50: 0.200nMAssay Description:For the PathScan phospho c-kit (Tyr719) sandwich ELISA: M-07e cells were resuspended at 2×106 cells/mL in phenol red free, serum-free, GM-CSF-free Is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 690292BDBM690292(N-[2-chloro-5-(2-cyclopropyl-2H-1,2,3,4-tetrazol-5...)
Affinity DataIC50: 0.200nMAssay Description:For the PathScan phospho c-kit (Tyr719) sandwich ELISA: M-07e cells were resuspended at 2×106 cells/mL in phenol red free, serum-free, GM-CSF-free Is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 690334BDBM690334((S)-N-(2-chloro-5-(2-cyclopropyl-2H-tetrazol-5-yl)...)
Affinity DataIC50: 0.200nMAssay Description:For the PathScan phospho c-kit (Tyr719) sandwich ELISA: M-07e cells were resuspended at 2×106 cells/mL in phenol red free, serum-free, GM-CSF-free Is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 690336BDBM690336(US20240262826, Compound 284 | (S)-N-(2-chloro-5-(2...)
Affinity DataIC50: 0.200nMAssay Description:For the PathScan phospho c-kit (Tyr719) sandwich ELISA: M-07e cells were resuspended at 2×106 cells/mL in phenol red free, serum-free, GM-CSF-free Is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.210nMAssay Description:Binding constant for KIT(V559D,V654A) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.210nMAssay Description:Binding constant for KIT(V559D,V654A) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of KIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31095BDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  0.25nMAssay Description:Binding constant for KIT(V559D,V654A) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31095BDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  0.25nMAssay Description:Binding constant for KIT(V559D,V654A) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of KIT D816V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331096BDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataKd:  0.270nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human Nav1.4 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.280nMAssay Description:Binding constant for KIT(V559D,T670I) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.280nMAssay Description:Binding constant for KIT(V559D,T670I) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31095BDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  0.290nMAssay Description:Binding constant for KIT(L576P) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit [V654A](Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 792527BDBM792527(2-(4-{5-[5-fluoro-6-(2-methoxyethoxy)-1H-indazol-3...)
Affinity DataIC50: 0.290nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 792929BDBM792929(US12552795, Compound 6)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 792930BDBM792930(US12552795, Compound 7)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472782BDBM472782(US10829493, Example 8 | US12552795, Compound 8)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472783BDBM472783(US10829493, Example 9 | US12552795, Compound 9)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 690309BDBM690309((R)-N-(5-(2-cyclopropyl-2H-tetrazol-5-yl)-4-fluoro...)
Affinity DataIC50: 0.300nMAssay Description:For the PathScan phospho c-kit (Tyr719) sandwich ELISA: M-07e cells were resuspended at 2×106 cells/mL in phenol red free, serum-free, GM-CSF-free Is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 792926BDBM792926(US12552795, Compound 3)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 792927BDBM792927(US12552795, Compound 4)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 469288BDBM469288(US10807985, Compound 63 | US10829493, Example 63 o...)
Affinity DataIC50: 0.300nMAssay Description:PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 792928BDBM792928(US12552795, Compound 5)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472780BDBM472780(US10829493, Example 6)
Affinity DataIC50: 0.300nMAssay Description:PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472788BDBM472788(US10829493, Example 14 | US12552795, Compound 14)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472779BDBM472779(US10829493, Example 5)
Affinity DataIC50: 0.300nMAssay Description:PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472789BDBM472789(US10829493, Example 15 | US12552795, Compound 15)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472778BDBM472778(US10829493, Example 4)
Affinity DataIC50: 0.300nMAssay Description:PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472790BDBM472790(US10829493, Example 16 | US12552795, Compound 16)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472777BDBM472777(US10829493, Example 3)
Affinity DataIC50: 0.300nMAssay Description:PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 690293BDBM690293(N-(5-(2-cyclopropyl-2H-tetrazol-5-yl)-4-fluoro-2-m...)
Affinity DataIC50: 0.300nMAssay Description:For the PathScan phospho c-kit (Tyr719) sandwich ELISA: M-07e cells were resuspended at 2×106 cells/mL in phenol red free, serum-free, GM-CSF-free Is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472775BDBM472775(US10829493, Example 1)
Affinity DataIC50: 0.300nMAssay Description:PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472784BDBM472784(US10829493, Example 10 | US12552795, Compound 11)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472786BDBM472786(US10829493, Example 12 | US12552795, Compound 12)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472788BDBM472788(US10829493, Example 14 | US12552795, Compound 14)
Affinity DataIC50: 0.300nMAssay Description:PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 472796BDBM472796(US10829493, Example 22 | US12552795, Compound 22)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
National Health Research Institutes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 690330BDBM690330(N-(2-chloro-5-(2-cyclopropyl-2H-tetrazol-5-yl)phen...)
Affinity DataIC50: 0.300nMAssay Description:For the PathScan phospho c-kit (Tyr719) sandwich ELISA: M-07e cells were resuspended at 2×106 cells/mL in phenol red free, serum-free, GM-CSF-free Is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2024
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 469288BDBM469288(US10807985, Compound 63 | US10829493, Example 63 o...)
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2026
Entry Details
US Patent

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