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Report error Found 2735 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 1'
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50293721(cid_44191096 | CHEMBL562551 | N-(4-chloro-3-methox...)
Affinity DataEC50:  2.34E+3nMAssay Description:Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM55081(ML182 | VU0400195-3 | cid_46869947)
Affinity DataEC50:  1.45E+3nMAssay Description:Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu1 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as induction of increa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mGlu1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50283472(CHEMBL4160748)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor expressed in HEK cells assessed as increase in glutamate-induced calcium flux incubated for 142 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407827(CHEMBL2115160)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for the half-maximal inhibition of cAMP formation in BHK cells expressing mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407821(CHEMBL2115151)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407829(CHEMBL2115153)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407822(CHEMBL2114112)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407824(CHEMBL2114115)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407831(CHEMBL2115156)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407818(CHEMBL2114109)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407830(CHEMBL2115157)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407825(CHEMBL2114110)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407823(CHEMBL2114116)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407820(CHEMBL2115159)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407826(CHEMBL2114105)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407828(CHEMBL2114106)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50076393((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-phenyl-c...)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500947(CHEMBL3797811)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50500948(CHEMBL3800589)
Affinity DataEC50:  3.72E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  246nMAssay Description:Positive allosteric modulation of human mGlu1 receptor expressed in wild type T-Rex 293 cells assessed as increase in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  275nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  710nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500948(CHEMBL3800589)
Affinity DataEC50:  1.40E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500950(CHEMBL3799600)
Affinity DataEC50:  1.70E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  277nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  1.80E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  141nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate pEC50 at 10 uM (Rvb = 6.007 +/- 0.076 No_unit)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  181nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate EC50 at 10 uM (Rvb = 983.4 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500948(CHEMBL3800589)
Affinity DataEC50:  1.41E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500947(CHEMBL3797811)
Affinity DataEC50: <1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM87276(SMR000204124 | N-1,3-benzothiazol-2-yl-9H-xanthene...)
Affinity DataEC50:  4.79E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50500951(CHEMBL3799685)
Affinity DataEC50:  2.40E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  724nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500952(CHEMBL3799150)
Affinity DataEC50: <1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  182nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate pEC50 at 10 uM (Rvb = 6.007 +/- 0.076 No_unit)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM87276(SMR000204124 | N-1,3-benzothiazol-2-yl-9H-xanthene...)
Affinity DataEC50:  4.80E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50500948(CHEMBL3800589)
Affinity DataEC50:  3.60E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  245nMAssay Description:Positive allosteric modulation of human mGlu1 receptor expressed in wild type T-Rex 293 cells assessed as increase in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500951(CHEMBL3799685)
Affinity DataEC50:  900nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500952(CHEMBL3799150)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50500951(CHEMBL3799685)
Affinity DataEC50:  2.40E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500951(CHEMBL3799685)
Affinity DataEC50:  219nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate pEC50 at 10 uM (Rvb = 6.007 +/- 0.076 No_unit)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500951(CHEMBL3799685)
Affinity DataEC50:  219nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate EC50 at 10 uM (Rvb = 983.4 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500953(CHEMBL3798489)
Affinity DataEC50:  2.69E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500951(CHEMBL3799685)
Affinity DataEC50:  912nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  141nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate EC50 at 10 uM (Rvb = 983.4 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  1.86E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50500950(CHEMBL3799600)
Affinity DataEC50:  1.70E+3nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
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