Compile Data Set for Download or QSAR
Report error Found 4959 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2'
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM85212(CAS_5311260 | NSC_5311260 | LY341495)
Affinity DataKi:  0.0780nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50202406((-)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)
Affinity DataEC50:  0.0890nMAssay Description:Agonist activity at human mGluR2 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50202406((-)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)
Affinity DataEC50:  0.0890nMAssay Description:Agonist activity at human mGluR2 assessed as effect on cAMP production in RGT cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50434136(CHEMBL2381640)
Affinity DataEC50:  0.160nMAssay Description:Agonist activity at human mGlu2 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataKi:  0.190nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM160821(US9682980, 3-(Cyclopropylmethyl)-7-(4-(3,6-difluor...)
Affinity DataEC50:  0.200nMpH: 7.0Assay Description:Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2018
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50618878(CHEMBL5405921)
Affinity DataKi:  0.320nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50034503(DCG-IV | (2S,2'R,3'R)-2-(2',3')-dicarboxycycloprop...)
Affinity DataKi:  0.368nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50004899(L-CCG-IV | 2-(Amino-carboxy-methyl)-cyclopropaneca...)
Affinity DataKi:  0.378nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM160822(US9682980, 7-(4-(3,6-Difluoro-2-methoxyphenyl)pipe...)
Affinity DataEC50:  0.400nMpH: 7.0Assay Description:Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2018
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50209116(CHEMBL3883435)
Affinity DataEC50:  0.400nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50209108(CHEMBL3884532)
Affinity DataEC50:  0.400nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM213143(US9278960, 8-50 | US9636337, 8-50)
Affinity DataKi:  0.460nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50209220(CHEMBL3884187)
Affinity DataEC50:  0.5nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50434135(CHEMBL2381652)
Affinity DataEC50:  0.560nMAssay Description:Agonist activity at human mGlu2 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50094843((-)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...)
Affinity DataEC50:  0.570nMAssay Description:Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50094843((-)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...)
Affinity DataEC50:  0.570nMAssay Description:Agonist activity at mGLUR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50094843((-)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...)
Affinity DataEC50:  0.570nMAssay Description:Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50121540(CHEMBL3616857)
Affinity DataEC50:  0.580nMAssay Description:Agonist activity at human recombinant mGlu2 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50121539(CHEMBL3616856)
Affinity DataEC50:  0.650nMAssay Description:Agonist activity at human recombinant mGlu2 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50618874(CHEMBL5409898)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50618881(CHEMBL5418895)
Affinity DataKi:  0.740nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50618876(CHEMBL5429000)
Affinity DataKi:  0.780nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50618875(CHEMBL5394450)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50257518(CHEMBL4063313)
Affinity DataKi:  0.891nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50618871(CHEMBL5435246)
Affinity DataKi:  0.960nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50618873(CHEMBL5429261)
Affinity DataKi:  1nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50257555(CHEMBL4074664)
Affinity DataKd:  1nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50209103(CHEMBL3885379)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-JNJ-40068782 from human mGlu2 receptor expressed in HEK293 cell membranes coexpressing rat glutamate transporter measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50151448((1R,2R,3R,5R,6R)-2-Amino-3-(3-carboxy-benzyloxy)-6...)
Affinity DataKi:  1.06nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM252685(US9458176, 82)
Affinity DataIC50: 1.10nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM213109(US9278960, 8-16 | US9636337, 8-16)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50257595(CHEMBL4087196)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50257518(CHEMBL4063313)
Affinity DataEC50:  1.10nMAssay Description:Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50618870(CHEMBL5436775)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50257606(CHEMBL4073628)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50209117(CHEMBL3884636)
Affinity DataEC50:  1.30nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50434134(CHEMBL2381641)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human mGlu2 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50209103(CHEMBL3885379)
Affinity DataEC50:  1.40nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM213108(US9278960, 8-15 | US9636337, 8-15)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50151486((1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-ph...)
Affinity DataKi:  1.45nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50151439((1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-ph...)
Affinity DataKi:  1.48nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50618879(CHEMBL5405655)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50257556(CHEMBL4101354)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50257518(CHEMBL4063313)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50151481((1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-ph...)
Affinity DataKi:  1.61nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM252686(US9458176, 83)
Affinity DataIC50: 1.70nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM252846(US9458176, 243)
Affinity DataIC50: 1.70nMT: 2°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50209189(CHEMBL3883634)
Affinity DataEC50:  1.70nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM50618880(CHEMBL5410262)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human mGluR2 expressed in cell membrane incubated for 1 hr in presence of tritium labeled [3H]-7-((2,5-dioxopyrrolidin-1-yl)methy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
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