Compile Data Set for Download or QSAR
Report error Found 1569 Enz. Inhib. hit(s) with Target = 'Mineralocorticoid receptor'
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM19214([3H]Aldosterone | (1S,2R,10S,11S,14S,15R,17S)-17-h...)
Affinity DataEC50:  0.470nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM323679(US10188667, Example 00020 | US10188667, Example 00...)
Affinity DataEC50:  2.85nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM13775([3H]cortisol | (1S,2R,10S,11S,14R,15S,17S)-14,17-d...)
Affinity DataEC50:  2.90nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM323672(US10188667, Example 00024 | US10188667, Example 00...)
Affinity DataEC50:  2.94nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM323675(US10188667, Example 00025 | US10188667, Example 00...)
Affinity DataEC50:  3.17nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM323674(US10188667, Example 00029 | US10188667, Example 00...)
Affinity DataEC50:  5.27nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM323673(US10188667, Example 00027 | US10188667, Example 00...)
Affinity DataEC50:  5.68nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM323671(US10188667, Example 00012 | US10188667, Example 00...)
Affinity DataEC50:  7.46nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM323674(US10188667, Example 00029 | US10188667, Example 00...)
Affinity DataEC50:  9.29nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM323676(US10188667, Example 00030 | US10188667, Example 00...)
Affinity DataEC50:  15.6nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM323670(US10188667, Example 00011 | US10188667, Example 00...)
Affinity DataEC50: >100nMAssay Description:Mineralocorticoid receptor (MR) activation potency was assessed using a HEK 293T cell line containing the UAS-bla reporter (UAS-bla HEK 293T CELLSENS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50354850(BUDESONIDE | US10869929, Compound Budesonide | US1...)
Affinity DataEC50:  4.80nMAssay Description:Induction of nuclear translocation of human recombinant ProLabel-tagged mineralocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50455912(CHEMBL4204230)
Affinity DataEC50:  2.5nMAssay Description:Induction of nuclear translocation of human recombinant ProLabel-tagged mineralocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50455907(CHEMBL4217942)
Affinity DataEC50: >3.00E+3nMAssay Description:Induction of nuclear translocation of human recombinant ProLabel-tagged mineralocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50455946(CHEMBL4213791)
Affinity DataEC50: >3.00E+3nMAssay Description:Induction of nuclear translocation of human recombinant ProLabel-tagged mineralocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50455910(CHEMBL4214377)
Affinity DataEC50: >3.00E+3nMAssay Description:Induction of nuclear translocation of human recombinant ProLabel-tagged mineralocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50455949(CHEMBL4211724)
Affinity DataEC50:  3.20nMAssay Description:Induction of nuclear translocation of human recombinant ProLabel-tagged mineralocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50354851(Veramyst | FLUTICASONE FUROATE)
Affinity DataEC50: >3.00E+3nMAssay Description:Induction of nuclear translocation of human recombinant ProLabel-tagged mineralocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50455952(CHEMBL4217175)
Affinity DataEC50:  1.60nMAssay Description:Induction of nuclear translocation of human recombinant ProLabel-tagged mineralocorticoid receptor expressed in CHO-K1 cells after 3 hrs by luminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50500349(CHEMBL3746388)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mineralocorticoid receptor (unknown origin) expressed in HEK293 cells assessed as transcriptional activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM8903(CHEMBL103 | (1S,2R,10S,11S,14S,15S)-14-acetyl-2,15...)
Affinity DataKd:  0.390nMAssay Description:Affinity for recombinant Mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50407856(CHEMBL2112398)
Affinity DataKd:  20nMAssay Description:Affinity for recombinant Mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50407855(CHEMBL2112397)
Affinity DataKd:  20nMAssay Description:Affinity for recombinant Mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50422147(CHEMBL97531)
Affinity DataKd:  0.740nMAssay Description:Affinity for recombinant Mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM238159(US9394291, 4a | US10017502, Example 4b)
Affinity DataEC50:  13nMAssay Description:Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as induction of nuclear translocation of mineralocorticoid r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50318300(CHEMBL1095097 | SC-66110 | EPLERENONE)
Affinity DataEC50:  100nMAssay Description:Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as induction of nuclear translocation of mineralocorticoid r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM404273(US10017502, Example 6b)
Affinity DataEC50:  1nMAssay Description:Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as induction of nuclear translocation of mineralocorticoid r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50531569(CHEMBL4532472)
Affinity DataEC50:  0.0501nMAssay Description:Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as induction of nuclear translocation of mineralocorticoid r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50531568(CHEMBL4455600)
Affinity DataEC50:  13nMAssay Description:Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as induction of nuclear translocation of mineralocorticoid r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50531567(CHEMBL4557032)
Affinity DataEC50: <1.00E+4nMAssay Description:Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as induction of nuclear translocation of mineralocorticoid r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50531586(CHEMBL4462110)
Affinity DataEC50: <1.00E+4nMAssay Description:Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as induction of nuclear translocation of mineralocorticoid r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50550263(CHEMBL4748750)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at mineralocorticoid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50550263(CHEMBL4748750)
Affinity DataEC50: >5.00E+3nMAssay Description:Antagonist activity at mineralocorticoid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM19214([3H]Aldosterone | (1S,2R,10S,11S,14S,15R,17S)-17-h...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human MR expressed in CHO-K1 cells by PathHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50621751(CHEMBL5420532)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of Gal-DBD and NHRLBD fused MR (unknown origin) transfected in African green monkey CV-1 cells by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50621752(CHEMBL5396467)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of Gal-DBD and NHRLBD fused MR (unknown origin) transfected in African green monkey CV-1 cells by luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50298028(2-chloro-4-{[(3S)-1-methylpyrrolidin-3-yl][2-(trif...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at MR expressed in african green monkey CV-1 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50323524(4-(((6-((3-(2,6-dichlorophenyl)-5-isopropylisoxazo...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mineralocorticoid receptor-LBD expressed in HEK293 cells assessed as Gal4-DBD interaction by cellular mammalian one hybrid assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50323530(3-(((6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxa...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mineralocorticoid receptor-LBD expressed in HEK293 cells assessed as Gal4-DBD interaction by cellular mammalian one hybrid assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50323533(4-(((6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxa...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mineralocorticoid receptor-LBD expressed in HEK293 cells assessed as Gal4-DBD interaction by cellular mammalian one hybrid assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50353386(US8592410, 88 | CHEMBL1829763 | US8598163, 61 | US...)
Affinity DataEC50: >5.00E+3nMAssay Description:Binding affinity to MRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataEC50:  0.00200nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50355735(CHEMBL1911270)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50355730(CHEMBL1911274)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50355740(CHEMBL1911272)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50348415(CHEMBL1800985)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50348401(CHEMBL1801012)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM19214([3H]Aldosterone | (1S,2R,10S,11S,14S,15R,17S)-17-h...)
Affinity DataEC50:  3.80nMAssay Description:Agonist activity at mineralocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM50321176(rac-3-(4-Nitrophenylamino)-3-(3-fluorophenyl)-1-p-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Allergan

US Patent
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
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