Compile Data Set for Download or QSAR
Report error Found 413 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 7'
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM5931(cid_3025986 | CHEMBL296468 | N-(5-{[(5-tert-butyl-...)
Affinity DataKd:  650nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31099(CHEMBL45741 | Flavopiridol | cid_24867231 | 2-(2-c...)
Affinity DataKd:  620nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  520nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  1.60E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM81377(FIIN-1)
Affinity DataKd:  160nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM81378(FRIN-1)
Affinity DataKd:  130nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337134(US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...)
Affinity DataKd:  80nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM209410(US9266890, I-20)
Affinity DataKd:  550nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
US Patent

TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM209414(US9266890, I-24)
Affinity DataKd:  320nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
US Patent

TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337126(US9266890, IV-2 | CHEMBL1672987 | Scaffold, B19 | ...)
Affinity DataKd:  670nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
US Patent

TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337127(US9266890, IV-1 | 2-(2-methoxy-4-(4-methylpiperazi...)
Affinity DataKd:  19nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
US Patent

TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337128(US9266890, IV-7 | 2-((4-(4-hydroxypiperidin-1-yl)-...)
Affinity DataKd:  57nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
US Patent

TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337134(US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...)
Affinity DataKd:  80nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM209448(US9266890, IV-8)
Affinity DataKd:  50nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
US Patent

TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  5.32E+3nMAssay Description:Binding affinity to wild-type human partial length ERK5 (M1 to A409 residues) expressed in bacterial expression system measured after 1 hr by kinomes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  180nMAssay Description:Binding affinity to wild-type human partial length MAPK7 (M1 to A409 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50363196(CHEMBL1944698)
Affinity DataKd:  43nMAssay Description:Binding affinity to ERK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  4.47E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  3.19E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337134(US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...)
Affinity DataKd:  80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337127(US9266890, IV-1 | 2-(2-methoxy-4-(4-methylpiperazi...)
Affinity DataEC50:  190nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337128(US9266890, IV-7 | 2-((4-(4-hydroxypiperidin-1-yl)-...)
Affinity DataEC50:  240nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337129(2-((2-methoxy-4-morpholinophenyl)amino)-5,11-dimet...)
Affinity DataEC50:  260nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337135(CHEMBL1673047 | Benzo[e]pyrimido[5,4-b][1,4]diazep...)
Affinity DataEC50:  310nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50652938(CHEMBL5687010)
Affinity DataEC50:  4.68E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50652939(CHEMBL5687005)
Affinity DataEC50:  4.11E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337134(US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...)
Affinity DataEC50:  240nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50539935(CHEMBL4632948)
Affinity DataEC50: >500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50652940(CHEMBL5686992)
Affinity DataEC50:  240nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337136(4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]py...)
Affinity DataEC50:  320nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337131(2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperid...)
Affinity DataEC50:  160nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337126(US9266890, IV-2 | CHEMBL1672987 | Scaffold, B19 | ...)
Affinity DataEC50: >1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337139(11-ethyl-2-((2-methoxy-4-(4-methylpiperazin-1-yl)p...)
Affinity DataEC50:  200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337140(11-isopropyl-2-((2-methoxy-4-(4-methylpiperazin-1-...)
Affinity DataEC50:  230nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337141(11-cyclopentyl-2-((2-methoxy-4-(4-methylpiperazin-...)
Affinity DataEC50:  200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50652941(CHEMBL5686989)
Affinity DataEC50:  1.32E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337145(9-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)p...)
Affinity DataEC50:  1.24E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50337144(8-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)p...)
Affinity DataEC50:  1.14E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50652942(CHEMBL5687020)
Affinity DataEC50:  3.10E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50434069(CHEMBL2381339 | US9676792, Compound 24)
Affinity DataEC50:  260nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM199090(XMD17-109 | US9676792, Compound 26)
Affinity DataEC50:  80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50434070(CHEMBL2381340)
Affinity DataEC50:  90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to ERK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to ERK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to ERK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50326054(CHEMBL1240703)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to ERK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to ERK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to ERK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to ERK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  2.50E+3nMAssay Description:Binding constant for ERK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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