Compile Data Set for Download or QSAR
Report error Found 827 Enz. Inhib. hit(s) with Target = 'Palmitoleoyl-protein carboxylesterase NOTUM'
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM10849(CHEMBL113 | 1,3,7-trimethyl-3,7-dihydropurine-2,6-...)
Affinity DataEC50:  4.60E+4nMAssay Description:Inhibition of human notum transfected with HEK293 cell incubated for 16 hrs by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKd:  7.00E+6nMAssay Description:Binding affinity to human notum assessed as dissociation constant by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50539244(CHEMBL4648963)
Affinity DataEC50:  110nMAssay Description:Inhibition of NOTUM (unknown origin) transfected in human HEK293T cells harbouring TCF/LEF luciferase reporter gene assessed as activation of Wnt sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50539245(CHEMBL4632460)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of NOTUM (unknown origin) transfected in human HEK293T cells harbouring TCF/LEF luciferase reporter gene assessed as activation of Wnt sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50539246(CHEMBL4632439)
Affinity DataEC50:  210nMAssay Description:Inhibition of NOTUM (unknown origin) transfected in human HEK293T cells harbouring TCF/LEF luciferase reporter gene assessed as activation of Wnt sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50539247(CHEMBL4636894)
Affinity DataEC50:  170nMAssay Description:Inhibition of NOTUM (unknown origin) transfected in human HEK293T cells harbouring TCF/LEF luciferase reporter gene assessed as activation of Wnt sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50539248(CHEMBL4633059)
Affinity DataEC50:  220nMAssay Description:Inhibition of NOTUM (unknown origin) transfected in human HEK293T cells harbouring TCF/LEF luciferase reporter gene assessed as activation of Wnt sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50554460(CHEMBL4788846)
Affinity DataEC50:  3.50E+3nMAssay Description:Inhibition of NOTUM in human HEK293S cells harbouring TCF/LEF luciferase reporter gene assessed as activation wnt signalling pathway incubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50579723(CHEMBL5084693)
Affinity DataEC50:  530nMAssay Description:Inhibition of Notum 1 (unknown origin) expressed in HEK293 cells harbouring TCF/LEF luciferase reporter gene assessed as modulation of Wnt/beta-caten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50579725(CHEMBL5072324)
Affinity DataEC50:  300nMAssay Description:Inhibition of Notum 1 (unknown origin) expressed in HEK293 cells harbouring TCF/LEF luciferase reporter gene assessed as modulation of Wnt/beta-caten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583101(CHEMBL5088670)
Affinity DataEC50: >10nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583106(CHEMBL5079572)
Affinity DataEC50: >10nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583108(CHEMBL5082211)
Affinity DataEC50:  300nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583109(CHEMBL5076852)
Affinity DataEC50:  240nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583110(CHEMBL5079507)
Affinity DataEC50:  86nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583111(CHEMBL5078474)
Affinity DataEC50:  720nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583112(CHEMBL5079105)
Affinity DataEC50:  88nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583113(CHEMBL5079298)
Affinity DataEC50:  310nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583114(CHEMBL5074459)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583115(CHEMBL5075787)
Affinity DataEC50:  260nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583116(CHEMBL5087764)
Affinity DataEC50:  540nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583117(CHEMBL5074993)
Affinity DataEC50:  930nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583118(CHEMBL5088818)
Affinity DataEC50:  190nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583119(CHEMBL5069664)
Affinity DataEC50:  300nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583120(CHEMBL5085330)
Affinity DataEC50:  140nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583121(CHEMBL5092978)
Affinity DataEC50:  150nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583122(CHEMBL5078659)
Affinity DataEC50:  34nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583123(CHEMBL5091552)
Affinity DataEC50:  260nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583124(CHEMBL5092063)
Affinity DataEC50:  380nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583126(CHEMBL5093068)
Affinity DataEC50:  300nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583127(CHEMBL5077097)
Affinity DataEC50:  130nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583129(CHEMBL5087217)
Affinity DataEC50:  150nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583130(CHEMBL5088589)
Affinity DataEC50:  380nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583131(CHEMBL5070478)
Affinity DataEC50:  110nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583133(CHEMBL5077080)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583136(CHEMBL5076818)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50583137(CHEMBL5074284)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Notum (81 to 451 Cys330Ser) in HEK293T cells expressing TCF-LEF assessed as activation of Wnt signaling using WNT3A as substrate incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50154397(CHEMBL3774760)
Affinity DataEC50:  23nMAssay Description:Inhibition of C-terminal His-tagged Notum (Ser81-Thr451 Cys330Ser) (unknown origin) assessed as restoration of Wnt/beta catenin signalling activated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50144578(CHEMBL3760062)
Affinity DataEC50:  12nMAssay Description:Inhibition of C-terminal His-V5 tagged human Notum expressed in human HEK293F cells harbouring TCF/LEF luciferase reporter gene assessed as activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50154391(CHEMBL3775257)
Affinity DataEC50:  88nMAssay Description:Inhibition of C-terminal His-V5 tagged human Notum expressed in human HEK293F cells harbouring TCF/LEF luciferase reporter gene assessed as activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50154387(CHEMBL3774528)
Affinity DataEC50:  157nMAssay Description:Inhibition of C-terminal His-V5 tagged human Notum expressed in human HEK293F cells harbouring TCF/LEF luciferase reporter gene assessed as activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50154397(CHEMBL3774760)
Affinity DataEC50:  23nMAssay Description:Inhibition of C-terminal His-V5 tagged human Notum expressed in human HEK293F cells harbouring TCF/LEF luciferase reporter gene assessed as activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM10849(CHEMBL113 | 1,3,7-trimethyl-3,7-dihydropurine-2,6-...)
Affinity DataEC50:  4.58E+4nMAssay Description:Inhibition of human Notum (S81 to T451 residues) Cys330Ser mutant in human HEK293 cells expressing Renilla and STF reporter gene and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM10849(CHEMBL113 | 1,3,7-trimethyl-3,7-dihydropurine-2,6-...)
Affinity DataKd:  8.50E+4nMAssay Description:Binding affinity to human Notum (S81 to T451 residues) Cys330Ser mutant expressed in human HEK293T cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataKd:  6.80E+6nMAssay Description:Binding affinity to human Notum (S81 to T451 residues) Cys330Ser mutant expressed in human HEK293T cells by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM601033(1-[2,4-dichloro-3-(trifluoromethyl)phenyl]triazole...)
Affinity DataEC50:  110nMAssay Description:Inhibition of full length recombinant human Notum expressed in HEK293S cells expressing TCF-LEF preincubated for 30 mins followed by Wnt-3A addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50144372(CHEMBL3758668)
Affinity DataEC50:  30nMAssay Description:Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50144374(CHEMBL3759576)
Affinity DataEC50:  36nMAssay Description:Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50144375(CHEMBL3759908)
Affinity DataEC50:  61nMAssay Description:Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50144377(CHEMBL3759274)
Affinity DataEC50:  23nMAssay Description:Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details Article
PubMed
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