Compile Data Set for Download or QSAR
Report error Found 3228 Enz. Inhib. hit(s) with Target = 'S-adenosylmethionine synthase'
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50575977(CHEMBL4859703)
Affinity DataKd:  7.00E+4nMAssay Description:Binding affinity to MAT2A (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50581682(CHEMBL5078655)
Affinity DataKd:  6.20E+3nMAssay Description:Binding affinity to full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli assessed as dissociation constant by SPR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50581683(CHEMBL5078947)
Affinity DataKd:  2.50E+5nMAssay Description:Binding affinity to full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli assessed as dissociation constant by SPR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50581684(CHEMBL5084976)
Affinity DataKd: >2.00E+5nMAssay Description:Binding affinity to full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli assessed as dissociation constant by SPR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50581685(CHEMBL5074641)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli assessed as dissociation constant by SPR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50598612(CHEMBL337420)
Affinity DataKd:  170nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50641738(CHEMBL5565486)
Affinity DataEC50:  360nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  26nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  1.12E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756947(US20250221979, Example 252)
Affinity DataIC50: 0.140nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756962(US20250221979, Example 275)
Affinity DataIC50: 0.150nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756912(US20250221979, Example 189)
Affinity DataIC50: 0.320nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756847(US20250221979, Example 25)
Affinity DataIC50: 0.430nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756975(US20250221979, Example 298)
Affinity DataIC50: 0.430nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM757004(US20250221979, Example 354)
Affinity DataIC50: 0.460nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756961(US20250221979, Example 274)
Affinity DataIC50: 0.530nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756844(US20250221979, Example 22)
Affinity DataIC50: 0.540nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM757006(US20250221979, Example 357)
Affinity DataIC50: 0.540nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756876(US20250221979, Example 101)
Affinity DataIC50: 0.590nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756982(US20250221979, Example 311)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756865(US20250221979, Example 79)
Affinity DataIC50: 0.610nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756965(US20250221979, Example 283)
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756981(US20250221979, Example 310)
Affinity DataIC50: 0.740nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756908(US20250221979, Example 180)
Affinity DataIC50: 0.760nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756911(US20250221979, Example 187)
Affinity DataIC50: 0.760nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756890(US20250221979, Example 147)
Affinity DataIC50: 0.780nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756959(US20250221979, Example 272)
Affinity DataIC50: 0.780nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756969(US20250221979, Example 290)
Affinity DataIC50: 0.790nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756915(US20250221979, Example 196)
Affinity DataIC50: 0.810nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756873(US20250221979, Example 92)
Affinity DataIC50: 0.830nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756943(US20250221979, Example 244)
Affinity DataIC50: 0.860nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756972(US20250221979, Example 295)
Affinity DataIC50: 0.890nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756845(US20250221979, Example 23)
Affinity DataIC50: 0.910nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756960(US20250221979, Example 273)
Affinity DataIC50: 0.920nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756976(US20250221979, Example 303)
Affinity DataIC50: 0.920nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756991(US20250221979, Example 330)
Affinity DataIC50: 0.920nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756872(US20250221979, Example 91)
Affinity DataIC50: 0.930nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756953(US20250221979, Example 265)
Affinity DataIC50: 0.940nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM757022(US20250221979, Example 412)
Affinity DataIC50: 0.970nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM757010(US20250221979, Example 366)
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756848(US20250221979, Example 26)
Affinity DataIC50: 1.04nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756968(US20250221979, Example 289)
Affinity DataIC50: 1.04nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM757001(US20250221979, Example 351)
Affinity DataIC50: 1.05nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM757013(US20250221979, Example 373)
Affinity DataIC50: 1.05nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756951(US20250221979, Example 259)
Affinity DataIC50: 1.08nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756971(US20250221979, Example 294)
Affinity DataIC50: 1.08nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756978(US20250221979, Example 307)
Affinity DataIC50: 1.14nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM757023(US20250221979, Example 429)
Affinity DataIC50: 1.15nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756909(US20250221979, Example 182)
Affinity DataIC50: 1.16nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
TargetS-adenosylmethionine synthase isoform type-2(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM756903(US20250221979, Example 173)
Affinity DataIC50: 1.18nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
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