Compile Data Set for Download or QSAR
Report error Found 6220 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase ATR'
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)
Affinity DataEC50:  35nMAssay Description:Inhibition of ATR in human HCT116 cells assessed as after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  11nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  4.47E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043407(CHEMBL3355476)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM412060(US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...)
Affinity DataIC50: 0.150nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM350086(US10208027, Compound II-2 | 3-[3-[4-[dideuterio-(t...)
Affinity DataIC50: 0.170nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043409(CHEMBL3355474)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043385(CHEMBL3355072)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM724380(US20250066350, Example RP3500)
Affinity DataIC50: 0.330nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043387(CHEMBL3355074)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043408(CHEMBL3355475 | US20250051362, Comparative Compoun...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714736(US20250026742, Example 35-1)
Affinity DataIC50: 0.410nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043382(CHEMBL3355069)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043384(CHEMBL3355071)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043411(CHEMBL3355480)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR [14-953](Human)
Shanghai De Novo Pharmatech

US Patent
LigandPNGBDBM647614(US20240025899, Compound 3 | (R)-N,N-dimethyl-4-(3-...)
Affinity DataIC50: 0.510nMAssay Description:In this experiment, the phosphorylation level of substrate protein P53 (Eurofins, 14-952) was detected by HTRF technology to measure the activity of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714737(5-(5-amino-6-(5-(4-((1-methylpiperidin-4-yl)amino)...)
Affinity DataIC50: 0.570nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM268079(2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyr...)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase ATR [14-953](Human)
Shanghai De Novo Pharmatech

US Patent
LigandPNGBDBM647613(US20240025899, Compound 2 | (R)-3-methyl-4-(1-(met...)
Affinity DataIC50: 0.690nMAssay Description:In this experiment, the phosphorylation level of substrate protein P53 (Eurofins, 14-952) was detected by HTRF technology to measure the activity of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714724(1-(4-(5-(3-amino-6-(4-(cyclopropylsulfonyl)phenyl)...)
Affinity DataIC50: 0.700nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714728(1-(4-(5-(3-amino)-6-(1,1-dioxo-2,3-dihydrobenzo[b]...)
Affinity DataIC50: 0.75nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714739(US20250026742, Example 38-1)
Affinity DataIC50: 0.75nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714738(5-(5-amino-6-(5-(4-((methylamino)methyl)phenyl)-1,...)
Affinity DataIC50: 0.770nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM730138(US12264155, Compound 24)
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714712(1-(4-(5-(3-amino-6-(4-(isopropylsulfonyl)phenyl)py...)
Affinity DataIC50: 0.820nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714705(1-(4-(5-(3-amino-6-(4-isopropylsulfonyl)phenyl)pyr...)
Affinity DataIC50: 0.830nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714734(US20250026742, Example 33-1)
Affinity DataIC50: 0.830nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM724380(US20250066350, Example RP3500)
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714735(5-(5-amino-6-(5-(4-((methylamino)methyl)phenyl)iso...)
Affinity DataIC50: 0.920nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714718(1-(4-(5-(3-amino-6-(4-(isopropylsulfonyl)phenyl)py...)
Affinity DataIC50: 0.930nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714664(1-(4-(5-(3-amino-6-(4-(isopropylsulfonyl)phenyl)py...)
Affinity DataIC50: 0.970nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50468005(CHEMBL4288033)
Affinity DataIC50: 1nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50617689(CHEMBL5394792)
Affinity DataIC50: 1nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50585017(CERALASERTIB | Ceralasertib | Atr kinase inhibitor...)
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043383(CHEMBL3355070)
Affinity DataIC50: 1nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043386(CHEMBL3355073)
Affinity DataIC50: 1nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50043410(CHEMBL3355473)
Affinity DataIC50: 1nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714708(1-(4-(5-(3-amino-6-(4-(isopropylsulfonyl)phenyl)py...)
Affinity DataIC50: 1.04nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714725(1-(4-(5-(3-amino-6-(4-(isopropylsulfonyl)phenyl)py...)
Affinity DataIC50: 1.08nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM412060(US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...)
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714719(1-(4-(5-(3-amino-6-(4-(isopropylsulfonyl)phenyl)py...)
Affinity DataIC50: 1.16nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR [14-953](Human)
Shanghai De Novo Pharmatech

US Patent
LigandPNGBDBM647612(US20240025899, Compound 1 | Synthesis of (R)-3-met...)
Affinity DataIC50: 1.20nMAssay Description:In this experiment, the phosphorylation level of substrate protein P53 (Eurofins, 14-952) was detected by HTRF technology to measure the activity of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50617691(CHEMBL5417125)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714723(5-(5-(3-amino-6-(4-(propan-2-ylsulfonimido)phenyl)...)
Affinity DataIC50: 1.21nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714720(1-(6-(5-(3-amino-6-(4-(isopropylsulfonyl)phenyl)py...)
Affinity DataIC50: 1.26nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714729(N-(4-(5-(3-amino-6-(4-(isopropylsulfonyl)phenyl)py...)
Affinity DataIC50: 1.29nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM730169(US12264155, Compound 56)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714722(5-(5-(3-amino-6-(4-(isopropylsulfonyl)phenyl)pyraz...)
Affinity DataIC50: 1.31nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM694826(US20240294550, Example 20)
Affinity DataIC50: 1.40nMAssay Description:This experiment adopted Homogeneous time-resolved fluorescence technology (HTRF ) of Cisbio Company for assay.Experiment method: buffers were prepare...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM714715(1-(4-(5-(3-amino-6-(4-(isopropylsulfonyl)phenyl)py...)
Affinity DataIC50: 1.42nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

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