Compile Data Set for Download or QSAR
Report error Found 2112 Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2'
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20875(CHEMBL245067 | JMC511145 Compound 1 | 1-(2,4-dihyd...)
Affinity DataEC50:  35.6nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20877(CHEMBL183937 | JMC511145 Compound 2 | 3-(1-benzofu...)
Affinity DataEC50:  6.60nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2008
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataEC50:  9.20nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2008
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20879(CHEMBL429911 | N-ethyl-2,6-dihydroxy-5-[(4-methoxy...)
Affinity DataEC50:  1.30E+3nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2008
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataEC50:  1.10nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285388(CHEMBL4165421)
Affinity DataEC50:  175nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285389(CHEMBL4172842)
Affinity DataEC50:  88nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285390(CHEMBL4176765)
Affinity DataEC50:  46nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285392(CHEMBL4176991)
Affinity DataEC50:  151nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285393(CHEMBL4165713)
Affinity DataEC50:  211nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285394(CHEMBL4168847)
Affinity DataEC50:  65nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285395(CHEMBL4165004)
Affinity DataEC50:  204nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285396(CHEMBL4168361)
Affinity DataEC50:  2.25E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285397(CHEMBL4160788)
Affinity DataEC50:  194nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285399(CHEMBL4176700)
Affinity DataEC50:  173nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285400(CHEMBL4175153)
Affinity DataEC50:  8.54E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataEC50:  2nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285402(CHEMBL4173627)
Affinity DataEC50:  63nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285398(CHEMBL4169906)
Affinity DataEC50:  95nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285403(CHEMBL4161979)
Affinity DataEC50:  301nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285404(CHEMBL4161587)
Affinity DataEC50:  130nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285405(CHEMBL4172198)
Affinity DataEC50:  395nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285406(CHEMBL4170248)
Affinity DataEC50:  370nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285407(CHEMBL4159626)
Affinity DataEC50:  457nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285391(CHEMBL4164934)
Affinity DataEC50:  38nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285408(CHEMBL4176218)
Affinity DataEC50:  1.95E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285409(CHEMBL4161107)
Affinity DataEC50:  431nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285410(CHEMBL4164519)
Affinity DataEC50:  678nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285411(CHEMBL4171400)
Affinity DataEC50:  335nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285401(CHEMBL4166140)
Affinity DataEC50:  92nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20875(CHEMBL245067 | JMC511145 Compound 1 | 1-(2,4-dihyd...)
Affinity DataEC50:  79nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285412(CHEMBL4173333)
Affinity DataEC50:  208nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285413(CHEMBL4171709)
Affinity DataEC50:  396nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50285414(CHEMBL4175624)
Affinity DataEC50:  429nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataEC50:  1.10nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50386885(CANAGLIFLOZIN HYDRATE | CANAGLIFLOZIN | US10752604...)
Affinity DataEC50:  2.20nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM150162(US8980829, EMPAGLIFLOZIN | empagliflozin | BI-1077...)
Affinity DataEC50:  3nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50381554(CHEMBL2018096)
Affinity DataEC50:  7.40nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50511115(CHEMBL4552590)
Affinity DataEC50:  36nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50381537(CHEMBL2017954)
Affinity DataEC50:  5nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50315426((1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4...)
Affinity DataEC50:  2.30nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataEC50:  9.20nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50543520(CHEMBL4642473)
Affinity DataEC50:  33nMAssay Description:Inhibition of human SGLT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20877(CHEMBL183937 | JMC511145 Compound 2 | 3-(1-benzofu...)
Affinity DataEC50:  5.20nMAssay Description:Inhibition of human SGLT2 expressed in xenopus oocytes assessed as inhibition of [14C]AMG uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50595441(CHEMBL5198311)
Affinity DataEC50:  212nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C] labeled AMG accumulation incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50595442(CHEMBL5173206)
Affinity DataEC50:  286nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C] labeled AMG accumulation incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50595443(CHEMBL5169703)
Affinity DataEC50:  258nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C] labeled AMG accumulation incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50595444(CHEMBL5182440)
Affinity DataEC50:  455nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C] labeled AMG accumulation incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50595440(CHEMBL5169442)
Affinity DataEC50:  33nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C] labeled AMG accumulation incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM50595445(CHEMBL5208273)
Affinity DataEC50:  63nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C] labeled AMG accumulation incubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
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