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Report error Found 3583 Enz. Inhib. hit(s) with Target = 'Stimulator of interferon genes protein'
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604469(CHEMBL5187131)
Affinity DataEC50:  0.00400nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd: <0.0100nMAssay Description:Binding affinity to wild type mouse STING assessed as dissociation constant by Surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandPNGBDBM573971(US11453697, Example 247)
Affinity DataKd:  0.0200nMAssay Description:Binding affinity to wild type mouse STING assessed as dissociation constant by Surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM730218(US20250108123, Example II-1)
Affinity DataIC50: 0.0600nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM665297(US20240116909, Example 1 | 4-(5-(3-((2-(3-carboxyp...)
Affinity DataIC50: 0.0600nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataIC50: 0.0623nMAssay Description:Binding affinity to recombinant human His-tagged STING by measuring fluorescent signals in the presence of d2 labelled STING wild type ligand by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM730205(4,4'-((propane-1,3-diylbis(oxy))bis(6-methoxyisoin...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50509050(CHEMBL4438309)
Affinity DataEC50: <0.100nMAssay Description:Binding affinity to 6His-tagged human STING measured after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50509050(CHEMBL4438309)
Affinity DataEC50: <0.100nMAssay Description:Activation of human STING (139 to 379 residues) expressed in THP1-Blue ISG cells incubated for 24 hrs by quanti-blue SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM730221(US20250108123, Example II-4)
Affinity DataIC50: 0.180nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM665300(US20240116909, Example 4 | 4-(5-(3-((2-(3-carboxyp...)
Affinity DataIC50: 0.180nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM730235(US20250108123, Example II-20)
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM665315(US20240116909, Example 20 | 4-(5-(3-((2-(3-carboxy...)
Affinity DataIC50: 0.190nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM490791(US10968242, Example 18 | 9-((4S,6R,7S,11aR,13R,14R...)
Affinity DataKi:  0.190nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM730232(US20250108123, Example II-17)
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM665312(US20240116909, Example 17 | (S)-4-(5-(3-((2-((S)-3...)
Affinity DataIC50: 0.190nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM577477(US11472830, Cpd No. 9)
Affinity DataKd:  0.195nMAssay Description:Compounds were analyzed on an 5200 biacore SPR instrument (GE Healthcare). E.coli produced truncated STING protein was immobilized on a series S stre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50587689(CHEMBL5197229)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to human STING (137 to 379 residues) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM490777(US10968242, Example 3 Peak 4)
Affinity DataKi:  0.200nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM490773(US10968242, Example 2 Peak 4)
Affinity DataKi:  0.200nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604556(CHEMBL5175703)
Affinity DataIC50: 0.200nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM490791(US10968242, Example 18 | 9-((4S,6R,7S,11aR,13R,14R...)
Affinity DataKd:  0.200nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM665306(US20240116909, Example 10 | 4-(5-(3-((2-(3-carboxy...)
Affinity DataIC50: 0.280nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM665306(US20240116909, Example 10 | 4-(5-(3-((2-(3-carboxy...)
Affinity DataIC50: 0.280nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM490790(US10968242, Example 17 Peak 2)
Affinity DataKd:  0.300nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM490790(US10968242, Example 17 Peak 2)
Affinity DataKi:  0.300nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [155-341,H232R](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM669432(US11964978, Example AIF11)
Affinity DataKi:  0.300nMAssay Description:A radioligand binding assay was developed to determine whether compound interactions were competitive with a tritium-labeled version of the native ST...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2024
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM490777(US10968242, Example 3 Peak 4)
Affinity DataKd:  0.300nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50509399(CHEMBL4468010)
Affinity DataIC50: 0.300nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM665301(US20240116909, Example 5 | Sodium (S)-4-(5-(3-((2-...)
Affinity DataIC50: 0.320nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM730212(US20250108123, Example I-9)
Affinity DataIC50: 0.320nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM730222(sodium (S)-4-(5-(3-((2-((S)-3-carboxylatobutanoyl)...)
Affinity DataIC50: 0.320nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataEC50:  0.354nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM665302(US20240116909, Example 6 | Sodium (S)-4-(5-(3-((2-...)
Affinity DataIC50: 0.360nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM730223(US20250108123, Example II-7)
Affinity DataIC50: 0.360nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM457787(US10738074, Example 18)
Affinity DataEC50:  0.400nMAssay Description:16 nM of [3H] c-GAMP ligand was prepared by diluting into assay buffer, and 50 uL of this working stock was manually added to each well of the assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573927(US11453697, Example 97 | 2-amino-9-[(2R,5R,7R,8R,1...)
Affinity DataEC50:  0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM490772(US10968242, Example 2 Peak 3)
Affinity DataKd:  0.440nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM490790(US10968242, Example 17 Peak 2)
Affinity DataKd:  0.5nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM730225(US20250108123, Example II-9)
Affinity DataIC50: 0.650nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM665304(US20240116909, Example 8 | Sodium 4-(5-(3-((2-(3-c...)
Affinity DataIC50: 0.650nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM730208(US20250108123, Example I-4)
Affinity DataIC50: 0.680nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50509421(CHEMBL4577528)
Affinity DataIC50: 0.700nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573849(US11453697, Example 13 | 2-amino-9- [(5R,7R,8R,12a...)
Affinity DataEC50:  0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573838(US11453697, Example 2 | US11453697, Example 7 | (5...)
Affinity DataEC50:  0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM490773(US10968242, Example 2 Peak 4)
Affinity DataKd:  0.780nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50632884(CHEMBL5435411)
Affinity DataKd:  0.789nMAssay Description:Binding affinity to His-tagged wild type human STING C-terminal domain (149 to 379 residues) expressed in Escherichia coli BL21 (DE3) cells assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM573996(US11453697, Example 314 | 2-amino-9- [(5R,7R,8S,12...)
Affinity DataEC50: <1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM576130(US11466047, Example 27 | 2-amino-9- [(5R,7R,8S,12a...)
Affinity DataEC50: <1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM576128(US11466047, Example 20)
Affinity DataEC50:  1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

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