Compile Data Set for Download or QSAR
Report error Found 1162 Enz. Inhib. hit(s) with Target = 'Urease'
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50602006(CHEMBL5209436)
Affinity DataKd:  0.340nMAssay Description:Binding affinity to Helicobacter pyroli urease assessed as dissociation constant by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50532145(CHEMBL1549559)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of jack bean urease assessed as reduction in ammonia production using urea as substrate after 15 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50493380(CHEMBL2425469)
Affinity DataKi:  14nMAssay Description:Mixed-type competitive inhibition of Helicobacter pylori ATCC 43504 urease using urea as substrate by Lineweaver-burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50449762(CHEMBL4172924)
Affinity DataIC50: 18nMAssay Description:Inhibition of Helicobacter pylori ATCC 43504 urease assessed as reduction in ammonia production preincubated for 1.5 hrs under cell free condition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50223161(1-cyclohexyl-1-isopropyl-3,3-dimethylselenourea | ...)
Affinity DataKi:  25nMAssay Description:Inhibition of jack bean ureaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrease subunit alpha(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL
LigandPNGBDBM50449754(CHEMBL4167553)
Affinity DataIC50: 43nMAssay Description:Inhibition of Helicobacter pylori ATCC 43504 urease assessed as reduction in ammonia production preincubated for 1.5 hrs under cell free condition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50462868(CHEMBL4251246)
Affinity DataKi:  43nMAssay Description:Mixed-type inhibition of Helicobacter pylori ATCC 43504 urease assessed as enzyme-inhibitor complex using urea as substrate preincubated for 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50493373(CHEMBL2425478)
Affinity DataKi:  45nMAssay Description:Mixed-type competitive inhibition of Helicobacter pylori ATCC 43504 urease using urea as substrate by Lineweaver-burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50253257(CHEMBL4100084)
Affinity DataIC50: 50nMAssay Description:Inhibition of jack bean urease using urea as substrate pretreated for 15 mins followed by substrate addition by phenol red based spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2019
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50462868(CHEMBL4251246)
Affinity DataKi:  54nMAssay Description:Mixed-type inhibition of Helicobacter pylori ATCC 43504 urease assessed as enzyme-substrate-inhibitor complex using urea as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50449755(CHEMBL4162915)
Affinity DataIC50: 55nMAssay Description:Inhibition of Helicobacter pylori ATCC 43504 urease assessed as reduction in ammonia production preincubated for 1.5 hrs under cell free condition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM178021((Z)-N-(3-(4-aminosulfonylphenyl)-4-methylthiazol-2...)
Affinity DataIC50: 58nMpH: 8.2Assay Description:The urease inhibitory activity of synthesized sulfonamides (3a-j) was determined by measuring the amount of ammonia produced by the indophenols metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50253269(CHEMBL4092986)
Affinity DataIC50: 60nMAssay Description:Inhibition of jack bean urease using urea as substrate pretreated for 15 mins followed by substrate addition by phenol red based spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2019
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50449762(CHEMBL4172924)
Affinity DataKi:  60.2nMAssay Description:Mixed type non-competitive inhibition of urease in Helicobacter pylori ATCC 43504 assessed as enzyme-substrate-inhibitor complex constant preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50462869(CHEMBL4243350)
Affinity DataIC50: 61nMAssay Description:Inhibition of Helicobacter pylori ATCC 43504 urease assessed as reduction in ammonia production using urea as substrate preincubated for 1.5 hrs unde...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM178020((Z)-N-(3-(4-aminosulfonylphenyl)-4-methylthiazol-2...)
Affinity DataIC50: 64nMpH: 8.2Assay Description:The urease inhibitory activity of synthesized sulfonamides (3a-j) was determined by measuring the amount of ammonia produced by the indophenols metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50602006(CHEMBL5209436)
Affinity DataKi:  65nMAssay Description:Mixed type inhibition of Helicobacter pyroli urease assessed as dissociation constant for EI complex by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM178016((Z)-N-(3-(4-aminosulfonylphenyl)-4-methylthiazol-2...)
Affinity DataIC50: 72nMpH: 8.2Assay Description:The urease inhibitory activity of synthesized sulfonamides (3a-j) was determined by measuring the amount of ammonia produced by the indophenols metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetUrease [D459Y,K653P](Jack bean)
University of Karachi

LigandPNGBDBM152597(2-(1-(Benzofuran-2-yl)ethylidene)-N-(3-nitrophenyl...)
Affinity DataIC50: 77nMpH: 8.2Assay Description:The mixture of this enzyme inhibition assay was composed of 10 µL of enzyme (5 U/mL) and 10 µL of each test compound in the series (3a-3s) in 40 µL b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2015
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM178019((Z)-N-(3-(4-aminosulfonylphenyl)-4-methylthiazol-2...)
Affinity DataIC50: 81nMpH: 8.2Assay Description:The urease inhibitory activity of synthesized sulfonamides (3a-j) was determined by measuring the amount of ammonia produced by the indophenols metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM178022((Z)-N-(3-(4-aminosulfonylphenyl)-4-methylthiazol-2...)
Affinity DataIC50: 83nMpH: 8.2Assay Description:The urease inhibitory activity of synthesized sulfonamides (3a-j) was determined by measuring the amount of ammonia produced by the indophenols metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50493380(CHEMBL2425469)
Affinity DataIC50: 83nMAssay Description:Inhibition of urease extracted from Helicobacter pylori ATCC 43504 assessed as ammonia production preincubated for 1.5 hrs by indophenol-based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM178017((Z)-N-(3-(4-aminosulfonylphenyl)-4-methylthiazol-2...)
Affinity DataIC50: 83nMpH: 8.2Assay Description:The urease inhibitory activity of synthesized sulfonamides (3a-j) was determined by measuring the amount of ammonia produced by the indophenols metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM178014((Z)-N-(3-(4-aminosulfonylphenyl)-4-methylthiazol-2...)
Affinity DataIC50: 87nMpH: 8.2Assay Description:The urease inhibitory activity of synthesized sulfonamides (3a-j) was determined by measuring the amount of ammonia produced by the indophenols metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM178015((Z)-N-(3-(4-aminosulfonylphenyl)-4-methylthiazol-2...)
Affinity DataIC50: 87nMpH: 8.2Assay Description:The urease inhibitory activity of synthesized sulfonamides (3a-j) was determined by measuring the amount of ammonia produced by the indophenols metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetUrease [D459Y,K653P](Jack bean)
University of Karachi

LigandPNGBDBM152587(2-(1-(Benzofuran-2-yl)ethylidene)-N-phenylhydrazin...)
Affinity DataIC50: 89nMpH: 8.2Assay Description:The mixture of this enzyme inhibition assay was composed of 10 µL of enzyme (5 U/mL) and 10 µL of each test compound in the series (3a-3s) in 40 µL b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2015
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50356190(CHEMBL193474)
Affinity DataKi:  90nMAssay Description:Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50223158((S)-1,1-dimethyl-3-(1-(naphthalen-1-yl)ethyl)selen...)
Affinity DataKi:  94nMAssay Description:Inhibition of jack bean ureaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM178013((Z)-N-(3-(4-aminosulfonylphenyl)-4-methylthiazol-2...)
Affinity DataIC50: 96nMpH: 8.2Assay Description:The urease inhibitory activity of synthesized sulfonamides (3a-j) was determined by measuring the amount of ammonia produced by the indophenols metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50356190(CHEMBL193474)
Affinity DataIC50: 102nMAssay Description:Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetUrease [D459Y,K653P](Jack bean)
University of Karachi

LigandPNGBDBM152600(2-(1-(Benzofuran-2-yl)ethylidene)-N-(3-methoxyphen...)
Affinity DataIC50: 102nMpH: 8.2Assay Description:The mixture of this enzyme inhibition assay was composed of 10 µL of enzyme (5 U/mL) and 10 µL of each test compound in the series (3a-3s) in 40 µL b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2015
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50123230(CHEMBL3622691)
Affinity DataIC50: 120nMAssay Description:Inhibition of jack beans urease assessed as hydrolysis of urea into ammonia preincubated for 10 mins followed by urea addition measured after 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50356195(CHEMBL241902)
Affinity DataKi:  122nMAssay Description:Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50223159(3-dodecyl-1,1-dimethylthiourea | CHEMBL251521)
Affinity DataKi:  124nMAssay Description:Inhibition of jack bean ureaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM53627([[(E)-(5-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene...)
Affinity DataKi:  127nMAssay Description:Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50356195(CHEMBL241902)
Affinity DataIC50: 127nMAssay Description:Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50356192(CHEMBL241894)
Affinity DataKi:  127nMAssay Description:Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50449765(CHEMBL4159556)
Affinity DataIC50: 130nMAssay Description:Inhibition of Helicobacter pylori ATCC 43504 urease assessed as reduction in ammonia production preincubated for 1.5 hrs under cell free condition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUrease [D459Y,K653P](Jack bean)
University of Karachi

LigandPNGBDBM110170(Ethyl 4-[3-(3,4-dimethoxybenzoyl)thioureido]benzoa...)
Affinity DataIC50: 130nMpH: 8.2 T: 2°CAssay Description:The assay mixture contained 40 µL of buffer (0.01 M LiCl2, 1 mM EDTA, 0.01M K2HPO4, pH 8.2) containing 100 mM urea, 10 µL of enzyme (5U/mL)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2014
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50602006(CHEMBL5209436)
Affinity DataIC50: 130nMAssay Description:Inhibition of Helicobacter pylori ureaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50449763(CHEMBL4176964)
Affinity DataIC50: 130nMAssay Description:Inhibition of Helicobacter pylori ATCC 43504 urease assessed as reduction in ammonia production preincubated for 1.5 hrs under cell free condition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50356201(CHEMBL1910224)
Affinity DataKi:  134nMAssay Description:Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50223157(3-(4-bromobenzyl)-1,1-dimethylselenourea | CHEMBL3...)
Affinity DataKi:  135nMAssay Description:Inhibition of jack bean ureaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50452584(CHEMBL4208211)
Affinity DataIC50: 140nMAssay Description:Inhibition of jack bean urease assessed as reduction in ammonia production using urea as substrate after 15 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50253270(CHEMBL4071196)
Affinity DataIC50: 140nMAssay Description:Inhibition of jack bean urease using urea as substrate pretreated for 15 mins followed by substrate addition by phenol red based spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2019
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50449762(CHEMBL4172924)
Affinity DataIC50: 140nMAssay Description:Inhibition of urease in Helicobacter pylori ATCC 43504 assessed as reduction in ammonia production preincubated for 1.5 hrs by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50253275(CHEMBL4092021)
Affinity DataIC50: 150nMAssay Description:Inhibition of jack bean urease using urea as substrate pretreated for 15 mins followed by substrate addition by phenol red based spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2019
Entry Details Article
PubMed
TargetUrease(Jack bean)
University of Karachi

Curated by ChEMBL
LigandPNGBDBM50123347(CHEMBL3622680)
Affinity DataIC50: 150nMAssay Description:Inhibition of jack beans urease assessed as hydrolysis of urea into ammonia preincubated for 10 mins followed by urea addition measured after 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50534504(CHEMBL4590676)
Affinity DataIC50: 150nMAssay Description:Inhibition of Helicobacter pylori urease using urea as substrate assessed as ammonia production after 50 mins by indophenol methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
National Demonstration Center For Experimental Chemistry Education

Curated by ChEMBL
LigandPNGBDBM50449754(CHEMBL4167553)
Affinity DataKi:  152nMAssay Description:Mixed type non-competitive inhibition of urease in Helicobacter pylori ATCC 43504 assessed as enzyme-substrate-inhibitor complex constant preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
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