Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 13391
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768387BDBM768387((E)-1-(4-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataKi:  16nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 785454BDBM785454(US20250345339, Compound ELVN-002)
Affinity DataKi:  18nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 785453BDBM785453(US20250345339, Compound Zongertinib)
Affinity DataKi:  94nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768400BDBM768400((E)-1-(6-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768397BDBM768397((E)-1-(4-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768397BDBM768397((E)-1-(4-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768378BDBM768378(1-(3-(1-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7-...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768378BDBM768378(1-(3-(1-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7-...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768378BDBM768378(1-(3-(1-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7-...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768409BDBM768409((E)-1-(4-(4-((3-methyl-4- ((1-methyl-1H- benzo[d]i...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768409BDBM768409((E)-1-(4-(4-((3-methyl-4- ((1-methyl-1H- benzo[d]i...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768409BDBM768409((E)-1-(4-(4-((3-methyl-4- ((1-methyl-1H- benzo[d]i...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 785451BDBM785451(US20250345339, Compound 14)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768400BDBM768400((E)-1-(6-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768368BDBM768368((E)-1-(3-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768368BDBM768368((E)-1-(3-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768368BDBM768368((E)-1-(3-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768387BDBM768387((E)-1-(4-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768387BDBM768387((E)-1-(4-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768376BDBM768376(1-(4-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7-ylo...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768376BDBM768376(1-(4-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7-ylo...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768376BDBM768376(1-(4-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7-ylo...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 785445BDBM785445(US20250345339, Compound 3)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 785445BDBM785445(US20250345339, Compound 3)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 785445BDBM785445(US20250345339, Compound 3)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768387BDBM768387((E)-1-(4-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataKi:  290nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768397BDBM768397((E)-1-(4-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 350nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768387BDBM768387((E)-1-(4-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 350nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 785451BDBM785451(US20250345339, Compound 14)
Affinity DataIC50: 350nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768400BDBM768400((E)-1-(6-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 350nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 785453BDBM785453(US20250345339, Compound Zongertinib)
Affinity DataKi:  460nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 785454BDBM785454(US20250345339, Compound ELVN-002)
Affinity DataKi:  680nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 785451BDBM785451(US20250345339, Compound 14)
Affinity DataIC50: 3.25E+3nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent