Compile Data Set for Download or QSAR
Report error Found 180 Enz. Inhib. hit(s) with all data for entry = 50036895
TargetGenome polyprotein(Human rhinovirus B)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50065674(6-Carbamoyl-4-[2-(2-cyclopentylsulfanylcarbonylami...)
Affinity DataEC50:  56nMAssay Description:Effective concentration against human rhinovirus 3C protease.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGenome polyprotein(Human rhinovirus B)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50065602({1-[1-(3-Carbamoyl-1-formyl-propylcarbamoyl)-2-phe...)
Affinity DataEC50:  6.60E+4nMAssay Description:The effective concentration against Protease 3CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGenome polyprotein(Human rhinovirus B)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084657(1-Benzo[b]thiophen-6-ylmethyl-2,3-dioxo-2,3-dihydr...)
Affinity DataEC50: >5.60E+3nMAssay Description:Effective concentration against human rhinovirus-14 3C.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGenome polyprotein(Human rhinovirus B)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084671(4-{2-(4-Fluoro-benzyl)-7-methyl-5-[(5-methyl-isoxa...)
Affinity DataEC50:  5nMAssay Description:Effective concentration against human rhinovirus 3C protease.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGenome polyprotein(Human rhinovirus B)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084675({1-[1-(1-Dimethylcarbamoylmethyl-2-oxo-ethylcarbam...)
Affinity DataEC50:  1.30E+3nMAssay Description:The effective concentration against Protease 3CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084629(1-(3-Benzoylsulfanyl-2-methyl-propionyl)-4-phenyls...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084674([1-(1-Formyl-2-phenyl-ethylcarbamoyl)-2-phenyl-eth...)
Affinity DataIC50: 0.740nMAssay Description:Inhibitory activity against cathepsin L, lysosomal cysteine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084650({1-[1-Formyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-...)
Affinity DataIC50: 0.850nMAssay Description:Inhibitory activity against cathepsin L, lysosomal cysteine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50369775(Mavik | RU-44570 | TRANDOLAPRIL)
Affinity DataIC50: 0.930nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084622((4S)-4-cyclohexyl-1-({[2-methyl-1-(propanoyloxy)pr...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetRenin(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50046798(zankiren | 2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-d...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition activity against human plasma renin at pH=7.4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetRenin(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084627(2-(2-Amino-thiazol-4-ylmethyl)-N*4*-cyclohexylmeth...)
Affinity DataIC50: 1.40nMpH: 6.0Assay Description:Inhibitory concentration against human plasma renin at pH 6.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50021153([(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]a...)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084677(3-Methyl-2-(naphthalene-1-sulfonylamino)-pentanoic...)
Affinity DataIC50: 1.90nMAssay Description:Inhibitory activity against cathepsin LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084665(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1...)
Affinity DataIC50: 2nMAssay Description:Inhibition of matrix metalloprotease-8 (MMP-8).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084673(CHEMBL1165 | (S)-2-((S)-2-((S)-1-ethoxy-1-oxo-4-ph...)
Affinity DataIC50: 2.60nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084665(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1...)
Affinity DataIC50: 3nMAssay Description:Inhibition of matrix metalloprotease-9 (MMP-9).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetRenin(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084651(3-{2-[2-Benzyl-4-(4-methylamino-piperidin-1-yl)-4-...)
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against ReninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeprilysin(Rat)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50024102(((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-ace...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084681(CHEMBL1168 | 1-[2-(1-Ethoxycarbonyl-3-phenyl-propy...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50017129(Vasotec | Vaseretic | (SSS)1-[2-(1-Ethoxycarbonyl-...)
Affinity DataIC50: 4.5nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50367879(LISINOPRIL)
Affinity DataIC50: 4.70nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084646(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-decah...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084665(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1...)
Affinity DataIC50: 5nMAssay Description:Inhibition of matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084665(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1...)
Affinity DataIC50: 6nMAssay Description:Inhibition of matrix metalloprotease-2 (MMP-2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetRenin(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084618(A-70450 | 5-{2-[3-Benzyl-4-(4-methyl-piperazine-1-...)
Affinity DataIC50: 7.10nMAssay Description:Inhibitory concentration against renin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084617(YM-60828 | ((7-carbamimidoyl-naphthalen-2-ylmethyl...)
Affinity DataIC50: 7.70nMAssay Description:Inhibitory concentration against prothrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeprilysin(Rat)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084646(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-decah...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50368166(Accupril | QUINAPRIL)
Affinity DataIC50: 8.30nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeprilysin(Rat)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084679(SCH-39370 | 2-[1-(2-Carboxy-2-hydroxy-ethylcarbamo...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084666([6-(2-Mercapto-3-phenyl-propionylamino)-2,2-dimeth...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetRenin(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084615((4S,5S,7S)-5-Amino-7-(4-tert-butyl-3-methanesulfon...)
Affinity DataIC50: 13nMAssay Description:Inhibitory concentration against ReninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | {[(1R)-2-((2S)-2-{[(3-{[AMINO(IMINO...)
Affinity DataIC50: 17nMAssay Description:Inhibition against platelet aggregation without interacting directly with the nucleophilic serine of thrombin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCaspase-3(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50072046(3-Acetylamino-N-[3-(2-hydroxy-5-oxo-tetrahydro-fur...)
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against caspase-3.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM82258(NSC_3961 | CAS_114798-26-4 | Losartan)
Affinity DataIC50: 19nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084665(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-2,N*1...)
Affinity DataIC50: 20nMAssay Description:Inhibition of matrix metalloprotease-7 (MMP-7).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCathepsin D(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM7974(CHEMBL113208 | (3S,4S)-N-[(1S)-1-{[(1S)-1-carbamoy...)
Affinity DataIC50: 21nMAssay Description:Inhibitory concentration against Human cathepsin D.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataIC50: 23nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084623(4-Azido-1-(toluene-4-sulfonyl)-pyrrolidine-2-carbo...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against calpain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeprilysin(Rat)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50403562(UK-69578 | CHEMBL2062138)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084638(2-(3-Carbamimidoyl-benzyl)-3-[(3',4'-dimethoxy-bip...)
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCaspase-1(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50072044([(4S,7S,10aS)-4-((S)-2-Hydroxy-5-oxo-tetrahydro-fu...)
Affinity DataIC50: 36nMAssay Description:Inhibitory activity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084655([(S)-1-((S)-1-Formyl-pentylcarbamoyl)-3-methyl-but...)
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against Calpain 1 in platelets.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084637(Sivelestat | 2,2-Dimethyl-propionic acid 4-[2-(car...)
Affinity DataIC50: 44nMAssay Description:Inhibitory concentration against elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetProcathepsin L(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084652(2-(2-Benzyloxycarbonylamino-3-phenyl-propionylamin...)
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against cathepsin L, lysosomal cysteine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetPlasmepsin II(Plasmodium falciparum)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM8018((S)-3-(S)-Hydroxy-6-methyl-4-[(S)-3-methyl-2-(2-na...)
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration for Plasmodium falciparum plasmepsin-2. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGenome polyprotein(Human rhinovirus B)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084685(AcAsp-Glu-Dif-Glu-Cha-Cys | 4-(2-Acetylamino-3-car...)
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration against ProteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeprilysin(Rat)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084666([6-(2-Mercapto-3-phenyl-propionylamino)-2,2-dimeth...)
Affinity DataIC50: 63nMAssay Description:Inhibitory activity against EndopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084650({1-[1-Formyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-...)
Affinity DataIC50: 85.1nMAssay Description:Inhibitory activity against Cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetRenin(Human)
University of Queensland

Curated by ChEMBL
LigandPNGBDBM50084640(5-{2-[3-Benzyl-4-(4-methyl-piperazine-1-carbonyl)-...)
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against renin..More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
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