Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50009810
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088159(4-[3-Carboxy-1-(1H-tetrazol-5-yl)-propylcarbamoyl]...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity against thymidylate synthase from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088168(2-(4-Carboxy-4-{4-[(2-methyl-4-oxo-4,6,7,8-tetrahy...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity against thymidylate synthase from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088161(2-(4-Carboxy-4-{4-[(2-methyl-4-oxo-4,6,7,8-tetrahy...)
Affinity DataKi:  0.420nMAssay Description:Binding affinity against thymidylate synthase from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50408876(CHEMBL434602)
Affinity DataKi:  0.780nMAssay Description:Binding affinity against thymidylate synthase from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088164((S)-2-{4-[(2-Methyl-4-oxo-4,6,7,8-tetrahydro-3H-cy...)
Affinity DataKi:  0.780nMAssay Description:Binding affinity against thymidylate synthase from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50408872(CHEMBL58548)
Affinity DataKi:  1.10nMAssay Description:Binding affinity against thymidylate synthase from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50408871(CHEMBL60700)
Affinity DataKi:  1.70nMAssay Description:Binding affinity against thymidylate synthase from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50408877(CHEMBL412127)
Affinity DataKi:  2nMAssay Description:Compound was tested for the binding affinity against thymidylate synthase from L1210 mouse leukemia cells; value given as 0.9, 2.0More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50049170(CHEMBL301895 | CHEMBL353066 | (R)-2-((S)-4-Carboxy...)
Affinity DataKi:  2nMAssay Description:Binding affinity against thymidylate synthase from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50408874(CHEMBL299062)
Affinity DataKi:  2.20nMAssay Description:Binding affinity against thymidylate synthase from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088157(2-{4-[(2-Methyl-4-oxo-4,6,7,8-tetrahydro-3H-cyclop...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity against thymidylate synthase from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088169(4-(2-Benzenesulfonylamino-1-methyl-2-oxo-ethylcarb...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity against thymidylate synthase from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50408873(CHEMBL292920)
Affinity DataKi:  2.40nMAssay Description:Compound was tested for the binding affinity against thymidylate synthase from L1210 mouse leukemia cells; value given as 2.4,1.8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50408875(CHEMBL57549)
Affinity DataKi:  2.60nMAssay Description:Binding affinity against thymidylate synthase from L1210 mouse leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReduced folate transporter(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataKi:  3.50E+3nMAssay Description:Affinity towards RFC measured by the inhibition of [3H]MTX uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088164((S)-2-{4-[(2-Methyl-4-oxo-4,6,7,8-tetrahydro-3H-cy...)
Affinity DataKi:  6.00E+3nMAssay Description:Affinity towards RFC (Reduced folate carrier) measured by the inhibition of [3H]MTX uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088157(2-{4-[(2-Methyl-4-oxo-4,6,7,8-tetrahydro-3H-cyclop...)
Affinity DataKi:  1.40E+4nMAssay Description:Affinity towards RFC (Reduced folate carrier) measured by the inhibition of [3H]MTX uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088169(4-(2-Benzenesulfonylamino-1-methyl-2-oxo-ethylcarb...)
Affinity DataKi:  4.00E+4nMAssay Description:Affinity towards RFC (Reduced folate carrier) measured by the inhibition of [3H]MTX uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088168(2-(4-Carboxy-4-{4-[(2-methyl-4-oxo-4,6,7,8-tetrahy...)
Affinity DataKi:  6.90E+4nMAssay Description:Affinity towards RFC (Reduced folate carrier) measured by the inhibition of [3H]MTX uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088159(4-[3-Carboxy-1-(1H-tetrazol-5-yl)-propylcarbamoyl]...)
Affinity DataKi:  1.06E+5nMAssay Description:Affinity towards RFC (Reduced folate carrier) measured by the inhibition of [3H]MTX uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088161(2-(4-Carboxy-4-{4-[(2-methyl-4-oxo-4,6,7,8-tetrahy...)
Affinity DataKi:  1.50E+5nMAssay Description:Affinity towards RFC (Reduced folate carrier) measured by the inhibition of [3H]MTX uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Lactobacillus casei)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50049170(CHEMBL301895 | CHEMBL353066 | (R)-2-((S)-4-Carboxy...)
Affinity DataKi:  2.00E+5nMAssay Description:Affinity towards RFC (Reduced folate carrier) measured by the inhibition of [3H]MTX uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed