Compile Data Set for Download or QSAR
Report error Found 88 Enz. Inhib. hit(s) with all data for entry = 801
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6266(8-Cyclopentyl-2-[4-(2-diethylaminoethoxy)phenylami...)
Affinity DataIC50: 0.700nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6278(8-Cyclohexyl-2-[4-(4-methylpiperazin-1-yl)phenylam...)
Affinity DataIC50: 4nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6268(8-cycloheptyl-2-({4-[2-(diethylamino)ethoxy]phenyl...)
Affinity DataIC50: 4nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6277(8-{bicyclo[2.2.1]heptan-2-yl}-2-{[4-(4-methylpiper...)
Affinity DataIC50: 6nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6280(PD 0183812 | 8-Bicyclo[2.2.1]hept-2-yl-2-{4-[4-(3-...)
Affinity DataIC50: 8nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6276(Pyrido[2,3-d]pyrimidin-7-one 1 | 8-Cyclopentyl-2-[...)
Affinity DataIC50: 9nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6267(8-Cyclohexyl-2-[4-(2-diethylaminoethoxy)phenylamin...)
Affinity DataIC50: 11nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6275(8-(3-methylbutyl)-2-{[4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 13nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6278(8-Cyclohexyl-2-[4-(4-methylpiperazin-1-yl)phenylam...)
Affinity DataIC50: 15nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6278(8-Cyclohexyl-2-[4-(4-methylpiperazin-1-yl)phenylam...)
Affinity DataIC50: 20nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(8-Isopropyl-2-[4-(4-methylpiperazin-1-yl)phenylami...)
Affinity DataIC50: 32nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6279(8-Cyclopentyl-2-{4-[4-(3-hydroxypropyl)piperidin-1...)
Affinity DataIC50: 34nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6250(8-Butyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-...)
Affinity DataIC50: 37nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6256(8-Bicyclo[2.2.1]hept-2-yl-2-phenylamino-8H-pyrido[...)
Affinity DataIC50: 38nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6265(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-(pro...)
Affinity DataIC50: 45nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6254(8-Cyclohexyl-2-phenylamino-8H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50: 47nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6248(2-(phenylamino)-8-propyl-7H,8H-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 50nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6278(8-Cyclohexyl-2-[4-(4-methylpiperazin-1-yl)phenylam...)
Affinity DataIC50: 51nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(8-Isopropyl-2-[4-(4-methylpiperazin-1-yl)phenylami...)
Affinity DataIC50: 58nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6250(8-Butyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-...)
Affinity DataIC50: 58nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(8-Isopropyl-2-[4-(4-methylpiperazin-1-yl)phenylami...)
Affinity DataIC50: 70nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6278(8-Cyclohexyl-2-[4-(4-methylpiperazin-1-yl)phenylam...)
Affinity DataIC50: 79nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6245(8-Ethyl-2-[4-(4-methylpiperazin-1-yl)phenylamino]-...)
Affinity DataIC50: 85nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6231(8-Ethyl-2-[3-(1,1,2,2-tetrafluoroethoxy)phenylamin...)
Affinity DataIC50: 91nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6248(2-(phenylamino)-8-propyl-7H,8H-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 112nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6221(8-ethyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50: 129nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6273(8-Cyclopropyl-2-[4-(4-methylpiperazin-1-yl)phenyla...)
Affinity DataIC50: 140nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6247(2-(phenylamino)-8-(propan-2-yl)-7H,8H-pyrido[2,3-d...)
Affinity DataIC50: 145nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6252(8-(3-methylbutyl)-2-(phenylamino)-7H,8H-pyrido[2,3...)
Affinity DataIC50: 159nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6238(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...)
Affinity DataIC50: 160nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6280(PD 0183812 | 8-Bicyclo[2.2.1]hept-2-yl-2-{4-[4-(3-...)
Affinity DataIC50: 165nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6272(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-8-phen...)
Affinity DataIC50: 175nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6255(8-cycloheptyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]p...)
Affinity DataIC50: 182nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6249(8-(butan-2-yl)-2-(phenylamino)-7H,8H-pyrido[2,3-d]...)
Affinity DataIC50: 190nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6280(PD 0183812 | 8-Bicyclo[2.2.1]hept-2-yl-2-{4-[4-(3-...)
Affinity DataIC50: 209nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6253(8-cyclopentyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]p...)
Affinity DataIC50: 210nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6231(8-Ethyl-2-[3-(1,1,2,2-tetrafluoroethoxy)phenylamin...)
Affinity DataIC50: 238nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(8-Isopropyl-2-[4-(4-methylpiperazin-1-yl)phenylami...)
Affinity DataIC50: 270nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6251(8-Isobutyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin...)
Affinity DataIC50: 297nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6248(2-(phenylamino)-8-propyl-7H,8H-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 299nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6242(8-Ethyl-2-(4-(morpholin-4-yl)phenylamino)-8H-pyrid...)
Affinity DataIC50: 300nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6243(8-ethyl-2-{[4-(piperidin-1-yl)phenyl]amino}-7H,8H-...)
Affinity DataIC50: 300nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6239(2-{[4-(dimethylamino)phenyl]amino}-8-ethyl-7H,8H-p...)
Affinity DataIC50: 330nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6221(8-ethyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50: 410nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6269(8-Bicyclo[2.2.1]hept-2-yl-2-[4-(2-diethylaminoetho...)
Affinity DataIC50: 450nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6248(2-(phenylamino)-8-propyl-7H,8H-pyrido[2,3-d]pyrimi...)
Affinity DataIC50: 553nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6234(8-Ethyl-2-(4-hydroxyphenylamino)-8H-pyrido[2,3-d]p...)
Affinity DataIC50: 585nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6233(8-ethyl-2-[(4-methoxyphenyl)amino]-7H,8H-pyrido[2,...)
Affinity DataIC50: 600nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6221(8-ethyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50: 620nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(8-Isopropyl-2-[4-(4-methylpiperazin-1-yl)phenylami...)
Affinity DataIC50: 675nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
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