Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50010643
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50083680(1-(5-Bromo-pyridin-2-yl)-3-(2-thiophen-2-yl-ethyl)...)
Affinity DataIC50: 48nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097041(1-(5-Bromo-pyridin-2-yl)-3-[2-(4-hydroxy-phenyl)-e...)
Affinity DataIC50: 70nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097046(1-Furan-2-ylmethyl-3-thiazol-2-yl-thiourea | CHEMB...)
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097038(1-Adamantan-1-ylmethyl-3-thiazol-2-yl-thiourea | C...)
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097044(1-(2-Cyclohex-1-enyl-ethyl)-3-thiazol-2-yl-thioure...)
Affinity DataIC50: 900nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097038(1-Adamantan-1-ylmethyl-3-thiazol-2-yl-thiourea | C...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097039(1-(1-Phenyl-propyl)-3-thiazol-2-yl-thiourea | CHEM...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097046(1-Furan-2-ylmethyl-3-thiazol-2-yl-thiourea | CHEMB...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097039(1-(1-Phenyl-propyl)-3-thiazol-2-yl-thiourea | CHEM...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097042(1-[2-(1H-Indol-3-yl)-ethyl]-3-thiazol-2-yl-thioure...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50083680(1-(5-Bromo-pyridin-2-yl)-3-(2-thiophen-2-yl-ethyl)...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097042(1-[2-(1H-Indol-3-yl)-ethyl]-3-thiazol-2-yl-thioure...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097037(1-Thiazol-2-yl-3-(2-p-tolyl-ethyl)-thiourea | CHEM...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097040(1-(2-Phenoxy-ethyl)-3-thiazol-2-yl-thiourea | CHEM...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM1944(BHAP deriv. | N-[2-({4-[3-(propan-2-ylamino)pyridi...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097041(1-(5-Bromo-pyridin-2-yl)-3-[2-(4-hydroxy-phenyl)-e...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097049(1-(3-Imidazol-1-yl-propyl)-3-thiazol-2-yl-thiourea...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097049(1-(3-Imidazol-1-yl-propyl)-3-thiazol-2-yl-thiourea...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM1434(BI-RG-587 | 2-cyclopropyl-7-methyl-2,4,9,15-tetraa...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097040(1-(2-Phenoxy-ethyl)-3-thiazol-2-yl-thiourea | CHEM...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM1434(BI-RG-587 | 2-cyclopropyl-7-methyl-2,4,9,15-tetraa...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097044(1-(2-Cyclohex-1-enyl-ethyl)-3-thiazol-2-yl-thioure...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097047(1-Thiazol-2-yl-3-(2-thiophen-2-yl-ethyl)-thiourea ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in reverse tran...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM1944(BHAP deriv. | N-[2-({4-[3-(propan-2-ylamino)pyridi...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50097037(1-Thiazol-2-yl-3-(2-p-tolyl-ethyl)-thiourea | CHEM...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed