Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50005086
TargetNeuronal acetylcholine receptor subunit alpha-4(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataIC50: 0.0370nMAssay Description:Inhibition of [3H]nicotine binding to alpha4 nicotinic acetylcholine receptor in Mus musculus (mouse) M10 cells co-expressing beta2 nicotinic acetylc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit beta-like 2(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM50487992(CHEMBL2270633)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of [3H]IMI binding to Drosophila melanogaster neuronal acetylcholine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50078044(3-(6-Chloro-pyridin-3-ylmethyl)-3H-thiazol-2-ylide...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of [3H]nicotine binding to alpha4 nicotinic acetylcholine receptor in Mus musculus (mouse) M10 cells co-expressing beta2 nicotinic acetylc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit beta-like 2(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM50251868({(2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazol...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of [3H]IMI binding to Drosophila melanogaster neuronal acetylcholine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50472282(descyanothiacloprid)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of [3H]nicotine binding to alpha4 nicotinic acetylcholine receptor in Mus musculus (mouse) M10 cells co-expressing beta2 nicotinic acetylc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit beta-like 2(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM50212288((2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimida...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of [3H]IMI binding to Drosophila melanogaster neuronal acetylcholine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataIC50: 7nMAssay Description:Inhibition of [3H]nicotine binding to alpha4 nicotinic acetylcholine receptor in Mus musculus (mouse) M10 cells co-expressing beta2 nicotinic acetylc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50078048(1-(6-Chloro-pyridin-3-ylmethyl)-imidazolidin-(2Z)-...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of [3H]nicotine binding to alpha4 nicotinic acetylcholine receptor in Mus musculus (mouse) M10 cells co-expressing beta2 nicotinic acetylc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50078048(1-(6-Chloro-pyridin-3-ylmethyl)-imidazolidin-(2Z)-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of [3H]nicotine binding to alpha3 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cells co-expressing beta2beta4alpha5 Ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataIC50: 31nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataIC50: 45nMAssay Description:Inhibition of [3H]nicotine binding to alpha3 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cells co-expressing beta2beta4alpha5 Ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50487992(CHEMBL2270633)
Affinity DataIC50: 80nMAssay Description:Inhibition of [3H]nicotine binding to alpha4 nicotinic acetylcholine receptor in Mus musculus (mouse) M10 cells co-expressing beta2 nicotinic acetylc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataIC50: 160nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50487992(CHEMBL2270633)
Affinity DataIC50: 180nMAssay Description:Inhibition of [3H]nicotine binding to alpha3 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cells co-expressing beta2beta4alpha5 Ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit beta-like 2(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM50078044(3-(6-Chloro-pyridin-3-ylmethyl)-3H-thiazol-2-ylide...)
Affinity DataIC50: 185nMAssay Description:Inhibition of [3H]IMI binding to Drosophila melanogaster neuronal acetylcholine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit beta-like 2(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM50472282(descyanothiacloprid)
Affinity DataIC50: 200nMAssay Description:Inhibition of [3H]IMI binding to Drosophila melanogaster neuronal acetylcholine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit beta-like 2(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataIC50: 430nMAssay Description:Inhibition of [3H]IMI binding to Drosophila melanogaster neuronal acetylcholine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50251868({(2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazol...)
Affinity DataIC50: 860nMAssay Description:Inhibition of [3H]nicotine binding to alpha4 nicotinic acetylcholine receptor in Mus musculus (mouse) M10 cells co-expressing beta2 nicotinic acetylc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50487992(CHEMBL2270633)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit beta-like 2(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM50078048(1-(6-Chloro-pyridin-3-ylmethyl)-imidazolidin-(2Z)-...)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of [3H]IMI binding to Drosophila melanogaster neuronal acetylcholine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50212288((2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimida...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of [3H]nicotine binding to alpha4 nicotinic acetylcholine receptor in Mus musculus (mouse) M10 cells co-expressing beta2 nicotinic acetylc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit beta-like 2(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of [3H]IMI binding to Drosophila melanogaster neuronal acetylcholine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50078044(3-(6-Chloro-pyridin-3-ylmethyl)-3H-thiazol-2-ylide...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50472282(descyanothiacloprid)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50472282(descyanothiacloprid)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50078044(3-(6-Chloro-pyridin-3-ylmethyl)-3H-thiazol-2-ylide...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50078048(1-(6-Chloro-pyridin-3-ylmethyl)-imidazolidin-(2Z)-...)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50078048(1-(6-Chloro-pyridin-3-ylmethyl)-imidazolidin-(2Z)-...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50212288((2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimida...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of [3H]nicotine binding to alpha3 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cells co-expressing beta2beta4alpha5 Ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50487992(CHEMBL2270633)
Affinity DataIC50: 8.10E+4nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50251868({(2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazol...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50251868({(2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazol...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50212288((2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimida...)
Affinity DataIC50: 2.70E+5nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50212288((2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimida...)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed