Compile Data Set for Download or QSAR
Report error Found 81 Enz. Inhib. hit(s) with all data for entry = 896
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6988(N-tert-butyl-6-(thiophen-3-yl)-2-(trifluoromethyl)...)
Affinity DataIC50: 545nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM7001(6-(3-aminophenyl)-N-tert-butyl-2-(trifluoromethyl)...)
Affinity DataIC50: 600nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6995(4-[4-(tert-butylamino)-2-(trifluoromethyl)quinazol...)
Affinity DataIC50: 700nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6987(N-tert-butyl-2,6-bis(trifluoromethyl)quinazolin-4-...)
Affinity DataIC50: 790nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6986(N-[4-(tert-butylamino)-2-(trifluoromethyl)quinazol...)
Affinity DataIC50: 925nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6997(3-[4-(tert-butylamino)-2-(trifluoromethyl)quinazol...)
Affinity DataIC50: 1.00E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6993(N-tert-butyl-6-(2-methoxyphenyl)-2-(trifluoromethy...)
Affinity DataIC50: 1.00E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM7002(6-(4-aminophenyl)-N-tert-butyl-2-(trifluoromethyl)...)
Affinity DataIC50: 1.10E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM7002(6-(4-aminophenyl)-N-tert-butyl-2-(trifluoromethyl)...)
Affinity DataIC50: 1.10E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6985(4-(tert-butylamino)-2-(trifluoromethyl)quinazolin-...)
Affinity DataIC50: 1.15E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6990(N-tert-butyl-6-(thiophen-2-yl)-2-(trifluoromethyl)...)
Affinity DataIC50: 1.18E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6991(N-tert-butyl-6-(pyridin-3-yl)-2-(trifluoromethyl)q...)
Affinity DataIC50: 1.20E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6998(N-tert-butyl-6-[3-(pyridin-3-yl)phenyl]-2-(trifluo...)
Affinity DataIC50: 1.20E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6989(N-tert-butyl-6-(furan-2-yl)-2-(trifluoromethyl)qui...)
Affinity DataIC50: 1.20E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM7003(3-[4-(tert-butylamino)-2-(trifluoromethyl)quinazol...)
Affinity DataIC50: 1.30E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6972(N-(2-methylbutan-2-yl)-2-(trifluoromethyl)quinazol...)
Affinity DataIC50: 1.40E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6964(N-tert-butyl-2-(trifluoromethyl)quinazolin-4-amine...)
Affinity DataIC50: 1.50E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6992(N-tert-butyl-6-phenyl-2-(trifluoromethyl)quinazoli...)
Affinity DataIC50: 1.80E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM7001(6-(3-aminophenyl)-N-tert-butyl-2-(trifluoromethyl)...)
Affinity DataIC50: 2.10E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6977(2-methyl-2-{[2-(trifluoromethyl)quinazolin-4-yl]am...)
Affinity DataIC50: 2.30E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM7000(N-tert-butyl-6-(2,4-dichlorophenyl)-2-(trifluorome...)
Affinity DataIC50: 2.40E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM7003(3-[4-(tert-butylamino)-2-(trifluoromethyl)quinazol...)
Affinity DataIC50: 2.50E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6999(N-tert-butyl-6-(4-chlorophenyl)-2-(trifluoromethyl...)
Affinity DataIC50: 2.60E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6993(N-tert-butyl-6-(2-methoxyphenyl)-2-(trifluoromethy...)
Affinity DataIC50: 2.70E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6989(N-tert-butyl-6-(furan-2-yl)-2-(trifluoromethyl)qui...)
Affinity DataIC50: 3.00E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6981(N-[(1R)-1-phenylethyl]-2-(trifluoromethyl)quinazol...)
Affinity DataIC50: 3.20E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6996(N-tert-butyl-6-(3-methoxyphenyl)-2-(trifluoromethy...)
Affinity DataIC50: 3.30E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6988(N-tert-butyl-6-(thiophen-3-yl)-2-(trifluoromethyl)...)
Affinity DataIC50: 3.55E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6967(ethyl 4-(tert-butylamino)quinazoline-2-carboxylate...)
Affinity DataIC50: 5.80E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6963(N-tert-butyl-2-(trichloromethyl)quinazolin-4-amine...)
Affinity DataIC50: 6.10E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6990(N-tert-butyl-6-(thiophen-2-yl)-2-(trifluoromethyl)...)
Affinity DataIC50: 6.40E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6996(N-tert-butyl-6-(3-methoxyphenyl)-2-(trifluoromethy...)
Affinity DataIC50: 6.70E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6980(N-(1-phenylethyl)-2-(trifluoromethyl)quinazolin-4-...)
Affinity DataIC50: 6.80E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6992(N-tert-butyl-6-phenyl-2-(trifluoromethyl)quinazoli...)
Affinity DataIC50: 7.70E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6991(N-tert-butyl-6-(pyridin-3-yl)-2-(trifluoromethyl)q...)
Affinity DataIC50: 8.30E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6998(N-tert-butyl-6-[3-(pyridin-3-yl)phenyl]-2-(trifluo...)
Affinity DataIC50: 8.30E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6979(N-[(3,5-difluorophenyl)methyl]-2-(trifluoromethyl)...)
Affinity DataIC50: 8.90E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6994(N-tert-butyl-6-(4-methoxyphenyl)-2-(trifluoromethy...)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6995(4-[4-(tert-butylamino)-2-(trifluoromethyl)quinazol...)
Affinity DataIC50: 1.10E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6965(N-tert-butyl-2-(1,1,2,2,2-pentafluoroethyl)quinazo...)
Affinity DataIC50: 1.19E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6963(N-tert-butyl-2-(trichloromethyl)quinazolin-4-amine...)
Affinity DataIC50: 1.19E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM7000(N-tert-butyl-6-(2,4-dichlorophenyl)-2-(trifluorome...)
Affinity DataIC50: 1.20E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6997(3-[4-(tert-butylamino)-2-(trifluoromethyl)quinazol...)
Affinity DataIC50: 1.20E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6986(N-[4-(tert-butylamino)-2-(trifluoromethyl)quinazol...)
Affinity DataIC50: 1.40E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6984(N-(2-phenylpropan-2-yl)-2-(trifluoromethyl)quinazo...)
Affinity DataIC50: 1.40E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6964(N-tert-butyl-2-(trifluoromethyl)quinazolin-4-amine...)
Affinity DataIC50: 1.43E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6976({1-[2-(trifluoromethyl)quinazolin-4-yl]pyrrolidin-...)
Affinity DataIC50: 1.48E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6977(2-methyl-2-{[2-(trifluoromethyl)quinazolin-4-yl]am...)
Affinity DataIC50: 1.50E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6978(N-[(3-fluorophenyl)methyl]-2-(trifluoromethyl)quin...)
Affinity DataIC50: 1.56E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6983(N-[1-(4-fluorophenyl)ethyl]-2-(trifluoromethyl)qui...)
Affinity DataIC50: 1.65E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
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