Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50010903
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099960((1-Benzyl-1H-indazol-5-yl)-(6,7-dimethoxy-quinazol...)
Affinity DataIC50: 1nMAssay Description:Inhibition of rat Receptor protein-tyrosine kinase erbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of EGF receptor overexpressing HN5 cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099965((1-Benzyl-1H-indazol-5-yl)-quinazolin-4-yl-amine |...)
Affinity DataIC50: 10nMAssay Description:Inhibition of rat Receptor protein-tyrosine kinase erbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099969((2-Benzyl-1H-benzoimidazol-5-yl)-(6,7-dimethoxy-qu...)
Affinity DataIC50: 10nMAssay Description:Inhibition of rat Receptor protein-tyrosine kinase erbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 20nMAssay Description:Inhibition of erbB4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099971(N*4*-(1-Benzyl-1H-indol-5-yl)-pyrido[3,4-d]pyrimid...)
Affinity DataIC50: 26nMAssay Description:Inhibition of rat Receptor protein-tyrosine kinase erbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099966(N*4*-(1-Benzyl-1H-indazol-5-yl)-pyrido[3,4-d]pyrim...)
Affinity DataIC50: 27nMAssay Description:Inhibition of rat Receptor protein-tyrosine kinase erbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099968(N*4*-(2-Benzyl-1H-benzoimidazol-5-yl)-pyrido[3,4-d...)
Affinity DataIC50: 49nMAssay Description:Inhibition of rat Receptor protein-tyrosine kinase erbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099970((1-Benzyl-1H-indol-5-yl)-(6,7-dimethoxy-quinazolin...)
Affinity DataIC50: 49nMAssay Description:Inhibition of rat Receptor protein-tyrosine kinase erbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 70nMAssay Description:Inhibition of erbB2 overexpressing BT 474 cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099967((1-Benzyl-1H-indol-5-yl)-quinazolin-4-yl-amine | C...)
Affinity DataIC50: 90nMAssay Description:Inhibition of rat Receptor protein-tyrosine kinase erbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099966(N*4*-(1-Benzyl-1H-indazol-5-yl)-pyrido[3,4-d]pyrim...)
Affinity DataIC50: 97nMAssay Description:Inhibition of c-erbB-2 overexpressing HB4a cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 97nMAssay Description:Inhibition of erbB2 overexpressing HB4a.e5.2 cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 210nMAssay Description:Inhibition of EGF receptor overexpressing HN5 cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099961((2-Benzyl-2H-indazol-5-yl)-(6,7-dimethoxy-quinazol...)
Affinity DataIC50: 290nMAssay Description:Inhibition of rat Receptor protein-tyrosine kinase erbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099960((1-Benzyl-1H-indazol-5-yl)-(6,7-dimethoxy-quinazol...)
Affinity DataIC50: 290nMAssay Description:Inhibition of c-erbB-2 overexpressing HB4a cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099970((1-Benzyl-1H-indol-5-yl)-(6,7-dimethoxy-quinazolin...)
Affinity DataIC50: 350nMAssay Description:Inhibition of c-erbB-2 overexpressing HB4a cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 390nMAssay Description:Inhibition of erbB2 overexpressing Calu3 cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 390nMAssay Description:Inhibition of rat Receptor protein-tyrosine kinase erbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099959((2-Benzyl-1H-benzoimidazol-5-yl)-quinazolin-4-yl-a...)
Affinity DataIC50: 560nMAssay Description:Inhibition of rat Receptor protein-tyrosine kinase erbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099969((2-Benzyl-1H-benzoimidazol-5-yl)-(6,7-dimethoxy-qu...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of c-erbB-2 overexpressing HB4a cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099959((2-Benzyl-1H-benzoimidazol-5-yl)-quinazolin-4-yl-a...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of c-erbB-2 overexpressing HB4a cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099967((1-Benzyl-1H-indol-5-yl)-quinazolin-4-yl-amine | C...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of c-erbB-2 overexpressing HB4a cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099968(N*4*-(2-Benzyl-1H-benzoimidazol-5-yl)-pyrido[3,4-d...)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of c-erbB-2 overexpressing HB4a cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099961((2-Benzyl-2H-indazol-5-yl)-(6,7-dimethoxy-quinazol...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of c-erbB-2 overexpressing HB4a cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099962((3-Benzyl-3H-benzoimidazol-5-yl)-quinazolin-4-yl-a...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of rat Receptor protein-tyrosine kinase erbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Rat)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099964((1-Benzyl-1H-benzoimidazol-5-yl)-quinazolin-4-yl-a...)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of rat Receptor protein-tyrosine kinase erbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of MAPK kinase (MEK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099962((3-Benzyl-3H-benzoimidazol-5-yl)-quinazolin-4-yl-a...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of c-erbB-2 overexpressing HB4a cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099964((1-Benzyl-1H-benzoimidazol-5-yl)-quinazolin-4-yl-a...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of c-erbB-2 overexpressing HB4a cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of Raf kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Research Biomet. Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50099963(N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Src kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed