Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50036937
TargetBeta-secretase 1/2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100436(CHEMBL412768 | NH2-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibition of beta-secretase was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1/2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100434(tert-butyl (2S,3R,5R)-5-(((S)-1-((S)-1-amino-1-oxo...)
Affinity DataIC50: 300nMAssay Description:Inhibition of beta-secretase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGamma-secretase subunit PEN-2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50369830(CHEMBL1790471)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGamma-secretase subunit PEN-2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100435([1-(1-Formyl-butylcarbamoyl)-3-methyl-butyl]-carba...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGamma-secretase subunit PEN-2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGamma-secretase subunit PEN-2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100438(2-Acetylamino-4-methyl-pentanoic acid [1-(1-formyl...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100439(4-[2-(5-{2-[2-(2-Amino-3-carboxy-propionylamino)-3...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant beta-secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50100440(4-(2-{5-[2-(2-Amino-3-methyl-butyrylamino)-3-carba...)
Affinity DataKi:  68nMAssay Description:Inhibition of human recombinant beta-secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed