Compile Data Set for Download or QSAR
Report error Found 81 Enz. Inhib. hit(s) with all data for entry = 50011180
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 1.30nMAssay Description:Transcriptional repression of IL-1 stimulated IL-6 expression in native cells compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataIC50: 2.10nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103254(Dimethyl-carbamic acid 3-(10-methoxy-2,2,4-trimeth...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]- Dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataIC50: 3.80nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataKi:  4nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataIC50: 4nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103254(Dimethyl-carbamic acid 3-(10-methoxy-2,2,4-trimeth...)
Affinity DataIC50: 6nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataKi:  7.10nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataIC50: 8nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103250(5-(3,5-Difluoro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 9nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataIC50: 9nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103248(5-(3,5-Dimethyl-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 9.20nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062433(9-Chloro-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-6...)
Affinity DataKi:  9.30nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103250(5-(3,5-Difluoro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 10nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103250(5-(3,5-Difluoro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 11nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103247(10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-ph...)
Affinity DataKi:  11nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103254(Dimethyl-carbamic acid 3-(10-methoxy-2,2,4-trimeth...)
Affinity DataIC50: 12nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103253(5-(3-Bromo-5-methyl-phenyl)-10-methoxy-2,2,4-trime...)
Affinity DataIC50: 12nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103249(10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmeth...)
Affinity DataIC50: 16nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 16nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103248(5-(3,5-Dimethyl-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 18nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103245(9-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-...)
Affinity DataKi:  18nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103253(5-(3-Bromo-5-methyl-phenyl)-10-methoxy-2,2,4-trime...)
Affinity DataIC50: 18nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103255(10-Methoxy-5-(3-methoxymethoxy-phenyl)-2,2,4-trime...)
Affinity DataIC50: 23nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103248(5-(3,5-Dimethyl-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 24nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103254(Dimethyl-carbamic acid 3-(10-methoxy-2,2,4-trimeth...)
Affinity DataIC50: 26nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103255(10-Methoxy-5-(3-methoxymethoxy-phenyl)-2,2,4-trime...)
Affinity DataIC50: 28nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103253(5-(3-Bromo-5-methyl-phenyl)-10-methoxy-2,2,4-trime...)
Affinity DataIC50: 29nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataIC50: 30nMAssay Description:Transcriptional repression of IL-1 stimulated IL-6 expression in native cells compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103247(10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-ph...)
Affinity DataIC50: 32nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataKi:  37nMAssay Description:Binding affinity for mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataIC50: 41nMAssay Description:Glucocorticoid-induced aromatase activity in human skin fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103247(10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-ph...)
Affinity DataIC50: 44nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103255(10-Methoxy-5-(3-methoxymethoxy-phenyl)-2,2,4-trime...)
Affinity DataIC50: 49nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataIC50: 51nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using Dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062433(9-Chloro-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-6...)
Affinity DataKi:  53nMAssay Description:Binding affinity for progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103250(5-(3,5-Difluoro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 56nMAssay Description:Glucocorticoid-induced aromatase activity in human skin fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103247(10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-ph...)
Affinity DataIC50: 57nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 67nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataKi:  95nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataKi:  95nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103247(10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-ph...)
Affinity DataIC50: 105nMAssay Description:Glucocorticoid-induced aromatase activity in human skin fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 107nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataIC50: 123nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to DexamethasoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103255(10-Methoxy-5-(3-methoxymethoxy-phenyl)-2,2,4-trime...)
Affinity DataIC50: 131nMAssay Description:Glucocorticoid-induced aromatase activity in human skin fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50: 139nMAssay Description:Glucocorticoid-induced aromatase activity in human skin fibroblastsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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