Compile Data Set for Download or QSAR
Report error Found 67 Enz. Inhib. hit(s) with all data for entry = 50011389
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50: 0.0480nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106028((7S,8R,11S)-8-(3-naphthalen-1-yl-propyl)-9-oxo-2-o...)
Affinity DataIC50: 0.230nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106022((7S,8R,11S)-8-[3-(4-chloro-phenyl)-propyl]-9-oxo-2...)
Affinity DataIC50: 0.260nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106016((7S,8R,11S)-8-[3-(4-ethoxy-phenyl)-propyl]-9-oxo-2...)
Affinity DataIC50: 0.790nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106025((S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-b...)
Affinity DataIC50: 1.5nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106022((7S,8R,11S)-8-[3-(4-chloro-phenyl)-propyl]-9-oxo-2...)
Affinity DataIC50: 2.30nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106016((7S,8R,11S)-8-[3-(4-ethoxy-phenyl)-propyl]-9-oxo-2...)
Affinity DataIC50: 2.70nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106022((7S,8R,11S)-8-[3-(4-chloro-phenyl)-propyl]-9-oxo-2...)
Affinity DataIC50: 3.40nMAssay Description:Inhibitory concentration against Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106027((7S,8R,11S)-8-[3-(3,4-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 5.20nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50: 5.70nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106028((7S,8R,11S)-8-(3-naphthalen-1-yl-propyl)-9-oxo-2-o...)
Affinity DataIC50: 6nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106017(N-Hydroxy-2-methyl-3-[4-(3,4,5-trimethoxy-phenoxy)...)
Affinity DataIC50: 6.5nMAssay Description:Inhibitory concentration against Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106016((7S,8R,11S)-8-[3-(4-ethoxy-phenyl)-propyl]-9-oxo-2...)
Affinity DataIC50: 6.80nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106018((7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 6.80nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106023((7S,8R,11S)-9-Oxo-8-[3-(3,4,5-trimethoxy-phenyl)-p...)
Affinity DataIC50: 7.60nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106026((S)-2,2-Dimethyl-4-[4-(pyridin-3-yloxy)-benzenesul...)
Affinity DataIC50: 7.90nMAssay Description:Inhibitory concentration against Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106027((7S,8R,11S)-8-[3-(3,4-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106024((7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-...)
Affinity DataIC50: 11nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106021((7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-pro...)
Affinity DataIC50: 12nMAssay Description:Inhibitory concentration against Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106018((7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 13nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106025((S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-b...)
Affinity DataIC50: 21nMAssay Description:Inhibition against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106025((S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-b...)
Affinity DataIC50: 26nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106028((7S,8R,11S)-8-(3-naphthalen-1-yl-propyl)-9-oxo-2-o...)
Affinity DataIC50: 28nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106030((7S,8R,11S)-8-[3-(3,5-Bis-trifluoromethyl-phenyl)-...)
Affinity DataIC50: 33nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106019((7S,8R,11S)-11-benzoyl-8-[3-(3,5-dimethoxy-phenyl)...)
Affinity DataIC50: 43nMAssay Description:Inhibitory concentration against Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106031((7S,8R,11S)-11-benzoyl-9-oxo-8-[3-(3,4,5-trimethox...)
Affinity DataIC50: 55nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106032((7S,8R,11S)-11-Benzoyl-8-{3-[3-methoxy-5-(2-methox...)
Affinity DataIC50: 74nMAssay Description:Inhibitory concentration against Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106029((7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-p...)
Affinity DataIC50: 87nMAssay Description:Inhibitory concentration against Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106021((7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-pro...)
Affinity DataIC50: 96nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106024((7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-...)
Affinity DataIC50: 96nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106023((7S,8R,11S)-9-Oxo-8-[3-(3,4,5-trimethoxy-phenyl)-p...)
Affinity DataIC50: 110nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106018((7S,8R,11S)-8-[3-(2,5-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 140nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106023((7S,8R,11S)-9-Oxo-8-[3-(3,4,5-trimethoxy-phenyl)-p...)
Affinity DataIC50: 140nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106020(N-Hydroxy-2-methyl-3-[4-(3,4,5-trimethoxy-phenoxy)...)
Affinity DataIC50: 180nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106027((7S,8R,11S)-8-[3-(3,4-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 180nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106021((7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-pro...)
Affinity DataIC50: 220nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106027((7S,8R,11S)-8-[3-(3,4-dimethoxy-phenyl)-propyl]-9-...)
Affinity DataIC50: 230nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106029((7S,8R,11S)-11-Benzoyl-8-[3-(3,5-dibromo-phenyl)-p...)
Affinity DataIC50: 230nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106030((7S,8R,11S)-8-[3-(3,5-Bis-trifluoromethyl-phenyl)-...)
Affinity DataIC50: 300nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106024((7S,8R,11S)-11-Benzoyl-9-oxo-8-(3-p-tolyl-propyl)-...)
Affinity DataIC50: 320nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106016((7S,8R,11S)-8-[3-(4-ethoxy-phenyl)-propyl]-9-oxo-2...)
Affinity DataIC50: 400nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106017(N-Hydroxy-2-methyl-3-[4-(3,4,5-trimethoxy-phenoxy)...)
Affinity DataIC50: 430nMAssay Description:Inhibition against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106022((7S,8R,11S)-8-[3-(4-chloro-phenyl)-propyl]-9-oxo-2...)
Affinity DataIC50: 440nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106028((7S,8R,11S)-8-(3-naphthalen-1-yl-propyl)-9-oxo-2-o...)
Affinity DataIC50: 440nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106025((S)-2,2-Dimethyl-4-[4-(3,4,5-trimethoxy-phenoxy)-b...)
Affinity DataIC50: 550nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106019((7S,8R,11S)-11-benzoyl-8-[3-(3,5-dimethoxy-phenyl)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106021((7S,8R,11S)-8-[3-(3-isopropyl-5-methyl-phenyl)-pro...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106030((7S,8R,11S)-8-[3-(3,5-Bis-trifluoromethyl-phenyl)-...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106023((7S,8R,11S)-9-Oxo-8-[3-(3,4,5-trimethoxy-phenyl)-p...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50106019((7S,8R,11S)-11-benzoyl-8-[3-(3,5-dimethoxy-phenyl)...)
Affinity DataIC50: 2.90E+3nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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