Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 1205
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9989((2S,6S,15S)-6-hydroxy-2-(hydroxymethyl)-15-methylt...)
Affinity DataKi:  3.40nM ΔG°:  -50.3kJ/mole IC50: 31nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9997((2S,15S)-2-(hydroxymethyl)-15-methyltetracyclo[8.7...)
Affinity DataKi:  5.80nM ΔG°:  -48.9kJ/mole IC50: 49nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9994((2R,8R,15S)-8-hydroxy-2,15-dimethyltetracyclo[8.7....)
Affinity DataKi:  6nM ΔG°:  -48.8kJ/mole IC50: 50nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9996(CHEMBL421199 | (2R,15S)-2,15-dimethyltetracyclo[8....)
Affinity DataKi:  6.80nM ΔG°:  -48.5kJ/mole IC50: 60nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9992((2R,8S,15S)-8-hydroxy-2,15-dimethyltetracyclo[8.7....)
Affinity DataKi:  21nM ΔG°:  -45.6kJ/mole IC50: 190nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9987(4beta-hydroxyandrost-5-en-17-one | (2R,6S,15S)-6-h...)
Affinity DataKi:  25nM ΔG°:  -45.1kJ/mole IC50: 280nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9983(4alpha-Hydroxyandrost-5-en-17-one | (2R,6R,15S)-6-...)
Affinity DataKi:  58nM ΔG°:  -43.0kJ/mole IC50: 860nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9984(4alpha-Acetoxyandrost-5-en-17-one | (2R,6R,15S)-2,...)
Affinity DataKi:  60nM ΔG°:  -42.9kJ/mole IC50: 700nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9988(4beta-Acetoxyandrost-5-en-17-one | (2R,6S,15S)-2,1...)
Affinity DataKi:  90nM ΔG°:  -41.8kJ/mole IC50: 1.00E+3nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9995(6beta,19-dihydroxyandrost-4-en-17-one | (2S,8R,15S...)
Affinity DataKi:  110nM ΔG°:  -41.3kJ/mole IC50: 940nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9998((2R,15S)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{...)
Affinity DataKi:  120nM ΔG°:  -41.1kJ/mole IC50: 660nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9993((2S,8S,15S)-8-hydroxy-2-(hydroxymethyl)-15-methylt...)
Affinity DataKi:  250nM ΔG°:  -39.2kJ/mole IC50: 1.40E+3nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9985((2S,6R,15S)-6-hydroxy-2-(hydroxymethyl)-15-methylt...)
Affinity DataKi:  800nM ΔG°:  -36.2kJ/mole IC50: 6.80E+3nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9999((2S,15S)-2-(hydroxymethyl)-15-methyltetracyclo[8.7...)
Affinity DataKi:  1.00E+3nM ΔG°:  -35.6kJ/mole IC50: 6.90E+3nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9986((2S,6R,15S)-2-(hydroxymethyl)-15-methyl-14-oxotetr...)
Affinity DataIC50: 1.10E+4nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9990(4beta-Methoxy-19-hydroxyandrost-5-en-17-one | (2S,...)
Affinity DataIC50: 1.50E+5nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Tohoku Pharmaceutical University

LigandPNGBDBM9991((2S,6S,15S)-6-hydroxy-2-(methoxymethyl)-15-methylt...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2006
Entry Details Article
PubMed