Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50035187
TargetMetabotropic glutamate receptor 2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  7.40E+3nMAssay Description:Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 16nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant mGluR3 receptors expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50107108((1S,2S,3R)-2-(Amino-carboxy-methyl)-3-[2-(9H-xanth...)
Affinity DataIC50: 75nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant Metabotropic glutamate receptor 3 expressed in HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50107108((1S,2S,3R)-2-(Amino-carboxy-methyl)-3-[2-(9H-xanth...)
Affinity DataIC50: 200nMAssay Description:Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human Metabotropic glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 200nMAssay Description:Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50107109((1S,2S,3R)-2-(Amino-carboxy-methyl)-3-(9H-xanthen-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant Metabotropic glutamate receptor 3 expressed in HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50107109((1S,2S,3R)-2-(Amino-carboxy-methyl)-3-(9H-xanthen-...)
Affinity DataIC50: 6.40E+3nMAssay Description:Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human Metabotropic glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50107108((1S,2S,3R)-2-(Amino-carboxy-methyl)-3-[2-(9H-xanth...)
Affinity DataKi:  85nMAssay Description:Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human Metabotropic glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50107109((1S,2S,3R)-2-(Amino-carboxy-methyl)-3-(9H-xanthen-...)
Affinity DataKi:  2.70E+3nMAssay Description:Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human Metabotropic glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed