Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50011922
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112086(CHEMBL48361 | 3-({2-[(4-Carbamimidoyl-phenylamino)...)
Affinity DataKi:  4.5nMAssay Description:Inhibitory constant (Ki) was determined against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112083(3-({2-[(4-Carbamimidoyl-phenylamino)-methyl]-1-met...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112086(CHEMBL48361 | 3-({2-[(4-Carbamimidoyl-phenylamino)...)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112087(({2-[(4-Carbamimidoyl-phenylamino)-methyl]-1-methy...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112080(4-({2-[(4-Carbamimidoyl-phenylamino)-methyl]-1-met...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112085([{2-[(4-Carbamimidoyl-phenylamino)-methyl]-1-methy...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112073([{2-[2-(4-Carbamimidoyl-phenyl)-ethyl]-1-methyl-1H...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1/Trypsin-2(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112086(CHEMBL48361 | 3-({2-[(4-Carbamimidoyl-phenylamino)...)
Affinity DataKi:  50.3nMAssay Description:Inhibitory constant (Ki) was determined against human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112095(({2-[2-(4-Carbamimidoyl-phenyl)-ethyl]-1-methyl-1H...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112081([[2-(4-Carbamimidoyl-phenoxymethyl)-1-methyl-1H-be...)
Affinity DataIC50: 58nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112093([[2-(4-Carbamimidoyl-benzyl)-1-methyl-1H-benzoimid...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112079(4-[[2-(4-Carbamimidoyl-benzyl)-1-methyl-1H-benzoim...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50037996(N-[1-(4-Carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112074(4-[1-Methyl-5-(quinoline-8-sulfonylamino)-1H-benzo...)
Affinity DataIC50: 260nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112094({[2-(4-Carbamimidoyl-phenoxymethyl)-1-methyl-1H-be...)
Affinity DataIC50: 330nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112077(4-[5-(Isoquinoline-5-sulfonylamino)-1-methyl-1H-be...)
Affinity DataIC50: 510nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112089(4-[1-Methyl-5-(naphthalene-1-sulfonylamino)-1H-ben...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112076(4-[5-(Benzenesulfonyl-methyl-amino)-1-methyl-1H-be...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112082(4-(5-Benzenesulfonylamino-1-methyl-1H-benzoimidazo...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112092(4-[1-Methyl-5-(pyridine-3-sulfonylamino)-1H-benzoi...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112086(CHEMBL48361 | 3-({2-[(4-Carbamimidoyl-phenylamino)...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibitory constant (Ki) was determined against human plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112075(4-[5-(2,5-Dimethoxy-benzenesulfonylamino)-1-methyl...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112091(4-(5-Benzenesulfonylamino-1-ethyl-1H-benzoimidazol...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112086(CHEMBL48361 | 3-({2-[(4-Carbamimidoyl-phenylamino)...)
Affinity DataKi:  3.76E+3nMAssay Description:Inhibitory constant (Ki) was determined against human Coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112088(4-(5-Benzenesulfonylamino-1-propyl-1H-benzoimidazo...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112090(4-(5-Benzenesulfonylamino-1H-benzoimidazol-2-ylmet...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112086(CHEMBL48361 | 3-({2-[(4-Carbamimidoyl-phenylamino)...)
Affinity DataKi:  2.09E+4nMAssay Description:Inhibitory constant (Ki) was determined against human Activated protein CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112078(4-[1-Methyl-5-(naphthalene-2-sulfonylamino)-1H-ben...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112086(CHEMBL48361 | 3-({2-[(4-Carbamimidoyl-phenylamino)...)
Affinity DataKi:  4.54E+4nMAssay Description:Inhibitory constant (Ki) was determined against human Tissue plasminogen activator (tissue plasminogen activator)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50112084(4-[5-(3,5-Bis-trifluoromethyl-benzenesulfonylamino...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human thrombin by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed